RE: RNS Out17 May 2021 11:46
Results from paper for those with a busy lifestyle
Results the five SARS-CoV-2 single nucleotide polymorphisms (SNPs) were selected for their reportedassociationwith (i) an increase in SARS-CoV-2 transmission and / or (ii) diminished efficacy of monoclonal antibody therapy, convalescent plasma therapy, vaccine derived immunity, or naturally acquired immunity.10The sequences with more than 1% ambiguous bases were removed from the original dataset of 781,815 sequences. The remaining 640,482sequences were investigated usingthe VOC Genie algorithmdescribed in the Figure 1 below:At step (1) 640,482sequenceswere assessed for the presence of the N501Y mutation associated with increased transmission.324,234 sequences contained the SNPwhile 316,248 were wild typeand assessed at step (2)for the E484K and L452Rescape mutations.Surprisingly, 7,979 sequences contained the E484K mutation but did not contain the N501Y nor B.1.1.7identifiers. At step(3), only 2,866 sequences contained the E484K escape mutation while B.1.1.7was detected in over 321k sequences. The L452R SNP was detected in 13 sequences (4)
The panel of five SNP's detected all voc's and mutations of biological significance.
Now that's what you call a trial.