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"Scancell Holdings PLC (LON:SCLP) has published new research in a peer-reviewed journal highlighting the potential of its Modi-1 vaccine in hard-to-treat cancers. The drug developer said the research, published in Journal for ImmunoTherapy of Cancer, described Modi-1’s ability to stimulate potent T cell responses that translate into tumour protection in melanoma and ovarian cancer models. There was also evidence of a memory response to protect against a return of the tumour. Scancell added that technical challenges with one of the peptide components had also been successfully resolved enabling the manufacture of clinical supplies to begin in the third quarter of this year ahead of a first clinical trial".

https://www.proactiveinvestors.co.uk/companies/news/922630/scancell-publishes-new-research-highlighting-potential-of-modi-1-in-hard-to-treat-cancers-922630.html

"If you invest £1 and it increases in value to £10, what percentage increase have you made?"
I agree with Konar and Ray - the % increase is 900%

Thanks WTP . .

"Conclusions: Modi-1 citrullinated peptide vaccine induces potent CD4-mediated anti-tumor responses in mouse models and a CD4 T cell repertoire is present in ovarian cancer patients to the citrullinated peptides suggesting that Modi-1 could be an effective vaccine for ovarian cancer patients."

Thanks Inan. No and yes BioNTech do need a winner and they're not alone in that! But they have 8 trials in progress ?

Did you see anything of interest in their Investor update ?

Inan 19.25 - "Bio N tech needs a winner .................... keep an eye open". We all need a winner don't we ? An impressive Investor update here : https://seekingalpha.com/article/4355216-biontech-bntx-investor-presentation-slideshow?

Looking forward to a Scancell update . . . .

LLass. I noticed Stockholm itself had 14% and the rest of Sweden had acquired about 10% immunity. Sweden has dramatically worse stats than all it's neighbours and is not a good advert at all, for 'low intervention'.

Just one bit of research but I thought, interesting and with implications for vaccines ? (Sorry if it's been posted before).

"Immunity to coronavirus may last for as little as six weeks, new research from China suggests.
Levels of an antibody found in recovered COVID-19 patients fell sharply in 2-3 months after infection for both symptomatic and asymptomatic patients, according to the Chinese study.
Although the study was small, its outcome raises questions about the length of any immunity against the novel coronavirus. The research, published in Nature Medicine on June 18, highlights the risks of using COVID-19 'immunity passports' and supports the prolonged use of public health interventions such as social distancing and isolating high-risk groups, the researchers from Chongqing Medical University said." https://www.dailymail.co.uk/health/article-8446825/Antibody-levels-recovered-COVID-19-patients-decline-quickly-research.html

Viewings levelled off on Sunday afternoon but nevertheless 542K is a cracking tally! https://www.youtube.com/watch?v=q_DAkPMpTuw I was hoping we might see a few echoes around the media as a result, but so far, nothing at all? Surely there must be much wider awareness of 'Covidity' now - some tangible result to come hopefully ?

AvidiMab progress is interesting and thanks Inan and all for 'insights'. I'm looking forward to a much needed general update or even some 'left field' news. GLA

https://www.telegraph.co.uk/health-fitness/body/no-antibodies-could-still-have-had-covid-fighting-t-cells/

Prof. Robin Shattock of Imperial College on the 'Andrew Marr Show' 165 views https://www.youtube.com/watch?v=nSNedlt8Dzo&app=desktop

Prof. Lindy Durrant of Scancell and Nottingham University on 'Sky News' 534653 views https://www.youtube.com/watch?v=q_DAkPMpTuw

Inan - thanks - just noticed that on my morning scan - "Some experts believe T-cell immunity is likely to be more important for fighting coronavirus than antibodies" . . . .

"If you are unlucky enough to encounter the virus, it begins to bind to receptors in the mucus membranes at the back of your nose and throat. At that point, with the detection of a foreign protein in the body, the first immune phase kicks in. So-called “non-specific” immune cells, which respond to any invader instantly, set about tackling it. If they cannot, back-up is summoned: T cells. The involvement of T cells in the body’s response to Covid-19 was not clear until a pair of recent studies, one German one American, confirmed their presence in recovering patients. They take two forms: “helper” T cells and “killer” T cells. The latter attacks the virus directly and, says Sikora, “usually gobble it up”. “If they don’t,” he adds, “and the virus gets into the blood system.” It is then that the third line of defence (which “helper” T cells play a part in activating), kicks in. “It is called the ‘B-cell system’,” says Sikora “and it is this which makes antibodies.” "

Surely Prof. Sikora will have made the DT's 'Harry De Quetteville' specifically aware of Scancell's "Covidity' but maybe to make sure, some of us could ?

What an excellent article - it seems to be right on the Scancell button ! ATB

Just mischief.
Prof. Shattock views so far 117. Prof. Lindy views so far 526927 !!
Well done Mr Evans, Amanda Hayhurst and all Scancell . . .
I see you just beat me to it RW. GLA

https://www.youtube.com/watch?v=q_DAkPMpTuw

https://www.sharecast.com/news/aim-bulletin/scancell-upbeat-on-publication-of-avidimab-research--7539447.html

I'd agree with that WTP - the AvidiMab RNS brought not the snowball effect but a melt. Never mind - let's see if there are any 'echoes' around the Media on Covidity or Scancell tomorrow. I hope so.

Hi. I thought Crumb's comment would bring your response. Not unusually you are extremely indulgent in defending BJ & Co. I'd use your 'fighting fires with fire' analogy a different way. Perhaps good decisions would have been better than bad ones, like 'water' maybe. Example - the 2 metre rule is now seen as an obstacle to getting the economy going again. This Govt have spent 3 months dissing the concept (in the face of much evidence), suddenly the idea has to be rehabilitated !!

"Scientists have warned ministers that people will need to wear facecoverings and minimise their time together if they sit closer than 2 metres apart, according to the latest tranche of documents released by the UK government’s committee of experts. The advice from the Scientific Advisory Group for Emergencies (Sage) reflects the enormous challenge of reopening pubs, cafes and restaurants any time soon, despite mounting pressure on the government from some Tory MPs to relax physical distancing rules in England. Boris Johnson has so far resisted demands to reduce the limit from 2 metres to 1 metre to help businesses, particularly in the hospitality sector, to reopen over the summer". https://www.theguardian.com/society/2020/jun/12/people-will-need-face-masks-if-2-metre-rule-relaxed-experts-warn

You couldn't make it up - well said Crumbs.

Krafty by midnight on Sunday that'll be 600,000. That's my punt - anyone else ?

BTW the YouTube IS uploaded to the Scancell website now. I understand criticism of CH but we don't really know what he's up to do we ? There's a great deal going on and CH may well be driving many angles - including the coming funding needed - Covidity apart.

https://www.youtube.com/watch?v=q_DAkPMpTuw

Knowlesi - I saw your 'lifestyle' comment yesterday and thought it absurd - this IS progress for Scancell, it's been a good day or too with the Avidmab paper / AACR so why not enjoy it ?

https://www.youtube.com/watch?v=q_DAkPMpTuw

Crikey !