Member Info for Titania

https://www.nature.com/articles/d41586-022-00823-y

Me too!

https://www.reuters.com/business/healthcare-pharmaceuticals/drugmakers-scientists-begin-hunt-long-covid-treatments-2022-03-25/

Lets hope we are part of the answer to this!

https://onlinelibrary.wiley.com/doi/abs/10.1034/j.1600-0404.2002.01209.x

link to Interferon B1a

"Transforming growth factor ß (TGF-ß) plays a critical role in wound healing and the pathogenesis of fibrosis (scarring)."

Apologies if already posted. A paper re prevention of fibrosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893894/

"The bottom line is we’ve made tremendous progress across the last 14 months in the fight against COVID. And the President has a plan to sustain and build on this progress and ensure we remain prepared in the face of this very unpredictable virus. But we need Congress to act and provide $22.5 billion in immediate emergency funding so we can execute on the plan, so we can be prepared for whatever comes next."

https://www.whitehouse.gov/briefing-room/press-briefings/2022/03/23/press-briefing-by-white-house-covid-19-response-team-and-public-health-officials-84/

"This highlights the gene’s key role in the immune system and suggests that treating patients with interferon – proteins released by immune cells to defend against viruses – may help manage disease in the early stages."

The GenOMICC (Genetics of Susceptibility and Mortality in Critical Care) study

https://aboutmanchester.co.uk/research-team-supports-genetic-study-giving-extensive-new-insights-into-severe-covid-19/

We all know there is a small chance of an EUA application and that chance is worth something.

Sounds like he is still positive about interferon beta 1b!

Sorry Interferon beta 1a and Interferon beta 1b

Inclusion Criteria:
Hospitalized patient with COVID-19 requiring oxygen therapy
Patients hospitalized for less than 7 days.
Patients with symptoms for less than 10 days or RT-PCR (<96h) with Cycle Treshold < 25.

https://clinicaltrials.gov/ct2/show/NCT04469491

Synairgen has a patent for Interferon 1a and 1b!

Since breathlessness normally occurs day 5 to day 11 I am glad that Synairgen didn't opt for 7 days or less. But a cut off of two weeks not three would seem more sensible. Roll on Deep Dive Data to hopefully show that we can still help people after day 5!

"Criteria
Inclusion Criteria:
Clinical picture suggestive of COVID-19 dated 7 days or less."

https://clinicaltrials.gov/ct2/show/NCT04356495

Sprinter data 36% efficacious and interim data Activ-2 passing the master protocol hurdle of 40% efficacious and presumably significant. Could the combined analysis be greater than the two parts? Could they be combined. Would it still be underpowered?

With all those babies showing up on Synairgen's website does it look like an RSV trial could be on next. Not before Covid is concluded hopefully?

https://www.fiercebiotech.com/biotech/astrazeneca-sanofi-reveal-mixed-hand-high-stakes-rsv-game-hospitalization-miss-tarnishing

https://sciencebusiness.net/news/gates-foundation-launches-90m-fund-discover-antivirals-future-pandemics

Thanks

Yes maybe RM said that but does 5 years have to elapse for the official stability test result?

I was looking on Akron Biotech website and lots of product seem to have a shelf life of 24 months. Just wondering if SNG001 has a shelf life of 24 months? Wondering how frequently a stockpile might have to be re bought if it is not used.