Member Info for Timster

To be fair though most (including me) thought that the data which proves unequivocally that the platform works may have created a bit of interest and perhaps a rise.

But hey ho, avacta have now employed the "deal maker"

Cohort 7 should be completed soon

Two weekly dosing study had been recruiting and should start soon using ava6000 as a first line treatment.

So not sure eggy's no news due line is quite right.

Anyone there? Check the bins for leaflets...

Here's an answer from a recent Q&A that may help:

ADCs are trying to solve the same problem that pre|CISION is trying to solve – that of targeting a therapy to the tumour and avoiding systemic toxicities. pre|CISION addresses some challenges that ADCs face, namely: ADCs need to target an internalising tumour biomarker, expressed at very high levels on the surface of the tumour cell, and this affects the amount of drug that can be got into the cancer cells to kill them whereas pre|CISION therapies do not need to be internalised to release the drug. By targeting release of the payload in the tumour microenvironment, there will be a bystander effect i.e. all cells within the vicinity of the payload will be killed. ADCs are, in general, complex and expensive to manufacture, whereas pre|CISION chemotherapies are relatively simple and affordable. There is therefore scope for both approaches to coexist.

We are at the start LDA

Is this your new daily post now?

Bloody RAMPER, hope you happy with yourself Derek all the people who lost money from your ridiculous ramp.

Could just be starting the process, I think again at the meeting with the telegram group it was Confirmed they would rns first dosing.

This is her answer in Q&A

We have not finalised the choice of indications for the Phase 2 study yet. That will be further informed by the two weekly dose escalation study that we have now started.

At the meeting he had with the select few.

It was just to annoy robin to be honest.

But could be a cohort 7 rns and or 2 weekly study commencement very soon.

Loves a Thursday!

Explosive start to 2024

MTD soon LDA?

Indeed, perhaps Bella meant affimer

https://polaris.brighterir.com/public/avacta/news/rns/story/w0l7mlw

Eh? Pre|CISION requires a fap rich environment to cleave whatever it maybe delivering.

No

Wow, I thought lse had glitches then and we were back to the good old days of fan rivalry.

I'm waiting for a green box to appear where wynbore will be banging on about the lft days.

Joy of joys.

Can't reveal my sauces but it's on for sure.

Question 18 from Q&A

Now the P1A data has been released, can it still be published in a peer reviewed journal and/or at a major oncology conference. This was Avactas original aim but that changed, could you clarify why?

Yes it can. We have provided a summary of key findings and have more data that we can add to those to secure presentation slots at major conferences in 2024.

£200

So is £100,200.00 the Inc china price?

Only Sujood knows!!

Happy new year avactarians 🎉🎉

And one for eggy

Question 44 - In the pharmacokinetics data, why is Cmax so important?

Cmax is drives cardiotox, which reduced by up to 90% for ava6k over standard dox.

Importantly though this doesn't affect the efficacy of the drug.