Therapeutics Division: Roadmap15 Apr 2020 14:09
Proprietary programme IND submission Phase I trial
AVA6000 (pro-doxorubicin) Q2 2020 H2 2020
AVA004 (monotherapy – PD-L1 inhibitor) Q4 2020 H1 2021
AVA004/100 (TMAC molecule) H2 2021 H1 2022
AVA021 (bispecific therapy – PD-L1 & LAG-3 inhibitors) 2022 2022
AVA6000 Phase I trial is fully funded out of the Company’s existing cash resources.
- If the AVA6000 trial is successful, management believes that it will be in a position to secure a licensing deal
for the drug before end 2020. This would include upfront and near-term (within 12 months) milestone
payments of something in the region of $50m.
- This sum would be sufficient to cover all of the Company’s financing requirements until well into 2023,
including the three Phase I trials pencilled in for 2021 and 2022. By that stage we believe additional licensing
agreements would have been established, such that there is a reasonable possibility that Avacta would never
have to raise money again via the equity markets.
- A successful AVA6000 trial would likely fast-track other reformulated chemotherapies developed by the
pre|CISION platform – notably AVA3996, the FAP-activated proteasome inhibitor. We believe that it
could even leapfrog the intended AVA004 and AVA004/100 trials noted above, given the nearer term
opportunity for commercialisation.