Ben Richardson, CEO at SulNOx, confident they can cost-effectively decarbonise commercial shipping. Watch the video here.
Excellent news - and confirmation from SAR. Nice to see the call out of particular indications. Roll on completion of final preclinical studies and Clinical Trials Application now we are fully funded by our savvy HNWI investors.
Remember, no current competition in this TYK2 cancer sector. Worth billions in annual revenue across multiple countries and multiple cancer indications.
John Reader - genius
GLA
Hi All - it’s not the secret patent, this was lodged in April 2020 with the UK IPO
This to my mind is for SDC-1801. Both 1801 & 1802 were lodged as sub patents to our original 2013 TYK2 patents. These were lodged following selection of candidates after the SRI collaboration experiments. Both were contested by the US patent office as the original patent was granted and the examiner argued they were too similar to the original invention. John appealed and SDC-1802 was granted in January so I believe this is SDC-1801 as the granting of 1802 set a legal precedent.
I may be completely wrong though.
Stand by for an RNS in the coming weeks once we pay the cash and the patent is issued........could be the final ‘jigsaw’ piece.
GLA
Hi Potnak
If Dilly doesn’t want to progress he should have a moral inclination to return it before he is forced to. I’m sure with the right amount of will, Sierra could have brokered a suitable deal by now especially considering the research published into our CHK1. But no, he has removed all references to it from the website and its hidden......
ATB
Well Baton, Tim did amend his timeline from Q1 2022 to Q3 2021 for SDC-1801 autoimmune (not covid) following the HNWI’s investments. This Q3 period aligns nicely with the surfacing of the submarine patent protection. So IMHO we could see major news on many fronts:
1. CTA for SDC-1801
2. License for SDC-1801
3. Secret patent revealed
4. Preclinical update/completion SDC-1802
License of SDC-1802 (bundled with SDC-1801)
5. Covid Agile trials for SDC-1801
6. Sierra on license/restart of P2b &P3/license return to CPF/ICR/SAR
7. Aurora FLT3 relicense
8. Take over/buyout
GLA
Hi baton
It will surface soon........when pushed last year John claimed that for confidentiality of IP it could not be disclosed for 18 months, he was referring to the submarine patent protection. The laws around these submarine patents is that they have to surface after 18 months, we lodged the patent with the UK Intellectual Protection Office almost 17 months ago.......
I believe that the HNWI’s have seen ‘investment information’ at the Edison briefings that is linked to this patent and hence invested a collective of £3.5m over the past weeks in readiness for the reveal.
All the pipeline under development is reaching an inflection point that will be truly transformational.
Parker quote - Major Development
Reader quote - the world will know soon
GLA
An interesting similarity in both articles and commentary from BMS and Incyte is that both drugs will now be put forward for combo scenarios.
We already know SRA737 has been proven to work in combo with market leaders.......won’t be too much longer until Sierra has to blink or give back the license.
GLA
Hi All
2 notable FDA fails for PD(1)/PD(L1) from BMS (Opdivo) and Incyte (Retifanlimab) being reported on Endpoints. Bodes well for our SRA737………
https://endpts.com/fda-unsurprisingly-brings-down-the-hammer-on-incytes-pd-1-drawing-a-line-for-future-accelerated-approvals/
https://endpts.com/another-one-bites-the-dust-bristol-myers-squibb-pulls-dangling-accelerated-approval-for-opdivo-in-liver-cancer/
GLA
Hi All - and still the silence from Sareum is as deafening as ever, but oh so golden.
IMHO this just underpins that there is a major transformational deal being worked.
They told us we are superior to dexamethasone and our profile is similar to baricitinib but not a peep out of them since then.........Tyk tock tyk tock
So now we have an idea re the potential deaths from opening up and dropping all restrictions and further an understanding that some councils are planning for this, it is inconceivable that the government plans of fast track covid therapeutics have been dropped.
Boris made a specific announcement on April 21 from a pre written speech that he had launched the antiviral taskforce to search for British made and manufactured covid therapeutics - and even more do a covid pill.
I’m convinced this is all part of the planning for opening up that surely must be under development, just lacking announcement.
The issue will certainly become a hot topic with mainstream media in the coming weeks and maybe this is all part of Boris’s plan to pull the rabbit out of the hat........here’s hoping.
GLA
Yep agree Potnak - planning
The 32 individual borough councils of London thought that getting this procurement finalised was a smart move considering the central government had pre-announced the ‘freedom day’. They must not have as much confidence as the cabinet that things will be ok with opening up. An interesting requirement of the procurement was the ‘rapid deployment’ clause.........oh and the 4 year duration.
Fail to plan........plan to fail!!
GLA
Hi Cobradan - agree, it is a government’s responsibility to effectively plan.
Of interest, in this particular procurement (which to be honest you would have thought was already in place earlier in the pandemic) is the dates. Opened 12 June and Closed by 12 July with an award realistically not long after, oh just in time for lifting of all covid restrictions and preparedness for reaching ‘herd immunity’ before winter.
As per one of my earlier posts, Boris was asked directly “how many excess deaths did the modelling show by opening up all restrictions” - he did the typical politician answer by completely dodging the question. For balance, the same modelling has predicted some 100,000 cases per day should delta continue in the community unchecked.
Just saying as I don’t agree with the government decision to lift all restrictions too soon in its typical ‘flip flop’ chaotic way......stay safe
Therapeutics are needed - Gamma variant is on the way!
Hi All - this is looking dodgy......
The local government in London, England (UK) is letting a Contract valued at £6 Million, for Temporary Dead Body Storage.
The Westminster City Council is seeking:
"The Authority seeks to procure a framework agreement for temporary body storage in the event of an excess deaths situation for the 32 London boroughs and the City of London, led by Westminster City Council. The framework agreement will appoint a single provider and will be for a period of 4 years. This will be a contingency contract, only called upon in the event that an excess deaths situation arises in the future and existing local body storage capacity needs to be augmented."
the Request for Bids also outlines:
"The over-arching aim of this tender is to provide a single framework supplier that will be able to provide temporary body storage facilities to house deceased in the event of an excess deaths situation. The deceased will be stored with dignity and respect, at locations to be determined based on local London needs at the time and will require some design elements to accommodate local site conditions and constraints, while being capable of rapid deployment, construction and commissioning to an agreed standard. This framework will be procured by the Authority as the pan-London lead, but all London local authorities may call-off against the framework.
Naturally, one wonders what "excess deaths situation" the London City government is anticipating? Oh, and why does the contractor need to be able to provide "rapid deployment?"
Below is a direct link to the actual London Tender Request on the official government web site.
If government is looking to spend money for "dead body storage" it is not unreasonable to think they KNOW something, or are planning something that will require that capacity.
https://www.find-tender.service.gov.uk/Notice/013120-2021?origin=SearchResults&p=1
Either way, this is a very bad sign. Stay safe
Hi Num4
I’m with you on your post. Looking back, we have been on an incredible journey with absolutely brilliant research being ‘dug up’ and shared along the way. Overtime, we connected all the dots and challenged each other’s thinking in those very quiet years, someone said earlier it was sometimes only a few posts a day and volumes of a few hundred thousand. One of the best finds I think was attributed to citizen as it actually made SAR release an RNS to formally acknowledge the lupus paper released by the Department of Defence.
Thoth has been our inspiration (cheers Andy) and kept us going in the darkest days......rallying for an EGM and never giving in on 28p.
More than anything, I personally find the camaraderie between a group of anonymous individuals (we all know who we are) with an aligned understanding of SAR’s potential is a fascinating story that played out over more than 10 years, I look forward to the day when we all meet in person and put faces to alias’s and celebrate our story.
Good luck brothers and sisters have a great weekend!