focusIR May 2024 Investor Webinar: Blue Whale, Kavango, Taseko Mines & CQS Natural Resources. Catch up with the webinar here.
Hi Rick - yes had the same problem with Halifax (Lloyds) and my account with them is sell only. I have another account with ii.co.uk and so long as you prove your identity (quite thorough process) and your nominated account information aligns with your address of both UK based bank accounts and broker account you will be ok - not been an easy ride they are a nightmare to deal with.
Where in NZ are you?
Good luck
Hi Basser
Re right wing dinosaurs - this bunch had been found to be lining their pockets on the whole Brexit issue too. I wouldn’t be surprised at all if the Dino’s had engineered this opening up in full knowledge it won’t work but have been loading up in shares on what could be the solution to unlocking covid therefore making millions out of it........just saying!
Maybe Matt Hanc**k didn’t agree so they hung him out to dry......strange how those cctv images were leaked when there wasn’t even meant to be cctv in his chambers.......go figure!!
Hi All
So 16 days ago, SAR issued confirmation of completion for government funded Covid proof of concept experiments and the top line results stated our profile is superior to the only widely utilised therapeutic for covid ‘dexamethasone’.
Since then, nothing! No PR shouting from the rooftops, no proactive investors interview, no general tweets or ‘wink wink’ tweets. There is an obvious reason.......
We are seeing validation and confirmation for TYK2 almost daily from reputable academic and scientific sources.
Not too much longer - GLA
Re secret patent - to my reckoning this must be surfacing soon as the clock is currently at 16 months (April 2020 was the date if I’m correct).
As per my earlier post, I believe this will be the final piece of the jigsaw for FULL commercialisation.
The covid is a lovely little side angle that in itself could add millions more.
GLA
Hi All
Prof Chris Whitby commented:
"I don't think we should underestimate the fact that we could get into trouble again surprisingly fast," Professor Chris Whitty warns, as he says people should approach the end of most restrictions on Monday with caution.
He said the number of people in hospital with COVID-19 is doubling around every three weeks and could hit "quite scary numbers" if that trend is sustained.
"I don't think we should underestimate the fact that we could get into trouble again surprisingly fast," he told a webinar hosted by the Science Museum.
He added: "We are not by any means out of the woods yet on this, we are in much better shape due to the vaccine programme, and DRUGS and a VARIETY OF OTHER THINGS (what could he mean).
"But this has got a long way to run in the UK, and it's got even further to run globally."
Professor Whitty said that the key thing after 19 July was "to take things incredibly slowly", adding that he expects most people will still take precautions.
"If you look over what people have done, and in fact if you look at what people intend to do now, people have been incredibly good at saying, 'I may be a relatively low-risk, but people around me are at high-risk, and I'm going to modify my behaviours'," he said.
Looking ahead, Professor Whitty said that in the medium-term COVID-19 could mutate into a "vaccine escape variant" that could take the UK "some of the way backwards" to the worst days of the pandemic.
"The further out in time we go, the more TOOLS WE HAVE AT OUR DISPOSAL FROM SCIENCE, the less likely that is but you can never take that possibility completely off the table," he said.
"But you know, SCIENCE HAS DONE A PHENOMENAL JOB SO FAR AND IT WILL CONTINUE TO DO SO."
http://news.sky.com/story/covid-19-uk-not-out-of-the-woods-yet-and-pandemic-has-got-a-long-way-to-run-professor-chris-whitty-warns-12356827
GLA
Yes SOG completely agree.
IMHO the crystalline formulation patent is the key to unlocking the whole commercialisation of SAR. This should be approved/unveiled soon as when ‘poked’ about John said approx 18 months lodge time to protect our confidential IP. Lately, he made the comment when pushed again “the WORLD will find out soon” or words to that affect.
End game upon us - tyk tock tyk tock
Hi All
You will recall the events in 2019 (I think) when we applied for sub patent of our original Oxazole Tyrosine Kinase Inhibitors patent for SDC-1802 and the examiner rejected it “as it was too similar to the original” and you cannot patent something twice. John Reader appealed and showed the examiner the differences that he had discovered. This took some time but then not long we were granted the patent in Jan 2021 (refer RNS dated 07 Jan - US Patent Grant for TYK2/JAK1 Anticancer Candidate).
Another element that struck me is the recent reports around the covid vaccines and the apparent magnetic properties that some are experiencing around the vaccine site (deltoid) it’s a bit ‘tinfoil hat’ and with a pinch of salt.
However, it has been suggested that nano particles of magnetite are included in the vaccines that cause this magnetism. I looked into this and discovered that this is a technology that had been first trialled in the mid 2000’s as a solution to deliver chemotherapy drugs to tumor sites using magnetic delivery controlled from the outside of the body therefore releasing the drugs at the tumor site rather than through the whole body. Was this an attempt at early targeted precision medicine......
https://pubmed.ncbi.nlm.nih.gov/24715289
Superparamagnetic nanoparticle delivery of DNA vaccine - 2014
Before anyone asks, I have no idea why magnetic properties would be in the covid vaccines - if indeed it’s true.
Some of the doubters hanging around today and trying to infer negativity would do well to read the business plan of the company before starting to suggest nonsense.
SAR clearly state in every RNS that they are a drug discovery company specialising in small molecules for autoimmune and cancer and the business model is too license these discoveries at late preclinical stage/early clinical development.
Covid through a curved ball at the company and as such it finds itself in a position with new funding from the HNWI that it could start the next stage of trials development for SDC-1801 in the covid application following the encouraging results from the UK part funded proof of concept experiments. Alternatively, it could decide to align further with the government and opt for co funding/full funding in AGILE. This is exactly what the 01 July RNS states - “consultation with the experts’ - who do you suppose the experts are? Not too difficult to work out. If this happens, then the new investment funding will be used to push forward SDC-1801 into its own clinical trials for an autoimmune indication (yet to be confirmed) as soon as Q1 2022, this is also stated in the RNS ‘as running in parallel with covid trials’. Any funds remaining would also be used to complete the preclinical toxicology studies for SDC-1802.
Patience is the key, the BOD will not let this go on the cheap and will achieve the best outcome for all.
Those who got spiked - chill, relax, ignore the daily trading ‘noise’ and look forward to profit in the not too distant future - nothing to date has failed only got more validation and recognition.
GLA
By the time the HNWI has finished exercising they would have invested £3,040,000 in SAR.
I remember when either VAL or PYC secured a small valued contract and there sp went nuts.
We have almost £3+million and it goes down......der
Hold for GOLD
Part 2
Analysis of the Warwick modelling showed that many scenarios investigated lead to very large numbers of infected individuals, often in the YOUNGER AGE GROUPS (Thoth’s prediction), which may have implications for how the third wave is managed.
Scientists said that in particular, this large number of infections will increase the risk associated with the emergence of new variants.
They said the LHSTM modelling suggests that this summer wave of infections is expected to peak in August and in some scenarios, a smaller secondary peak will occur in the autumn and winter months.
And roughly half of the hospitalisations and deaths occurring this summer are likely to be in vaccinated individuals, depending upon vaccine coverage.
Testing capacity also appeared to come under question, with scientists saying: "There is high uncertainty around both the scale of the peak in prevalence and in the number of confirmed cases that this would correspond to.
"This would also depend on people's willingness to be tested and, potentially, on the capacity to test them."
Scientists also estimated the R number (reproduction rate of the virus) to have risen slightly from the previous week to 1.2 and 1.5 in England, with a growth rate between +3% and +7% per day, based on data up to 5 July.
GLA
Part 1 - More of the same from SAGE using the Warwick data
Scientists have urged the government to put contingency plans in place ready for surging hospital admissions as COVID cases are set to remain high until the end of August.
Members of the government scientific advisory committee SAGE summarised the latest modelling from Warwick, Imperial, LSHTM and Juniper for easing restrictions during a 7 July meeting and have issued their latest COVID-19 advice.
They said the number of hospitalisations likely to occur over the summer is uncertain, but likely to reach at least 1,000 a day, depending on the speed of changes following lockdown lifting.
The experts also suggested that the faster people return to pre-pandemic habits, the faster the next surge of infections will arise.
"It is not possible to predict how behaviours will change after 19 July," the scientists summarised.
"The closer that behaviours are to those seen before the pandemic and the more rapidly this state is reached, the larger the resurgence will be."
Latest SAGE summary pointers:
Scale of hospital admissions after 19 July "uncertain" and depends on behavioural changes
Government should put contingency plans in place to prepare for hospital admissions surge
Continued working from home and mask-wearing could reduce transmission
Larger number of infections will increase chances of new variants emerging
VACCINATED people to make up HALF of hospitalisations and DEATHS this summer (IMO – the vaccines don’t stop you dying)
England R number estimated between 1.2 and 1.5 - slight rise on previous week (the early pandemic targets were to keep this below 1.0 for opening???)
SAGE also said the next peak will be considerably smaller than that of January 2021, but the prevalence of infection will remain high for at least the rest of the summer.
They said if behaviours take longer to return to pre-pandemic levels and/or if the seasonal effect of transmission is higher, the peak of the summer wave is likely to be lower, resulting in a wave that is broader.
However, the Imperial modelling led scientists to assume that in a worst-case scenario, hospitalisations and deaths in the next wave could exceed those seen in the second wave.
But they said central scenarios suggest hospitalisation numbers are comparable with the second wave, while deaths will be substantially lower.
They said the scale of hospital admissions in the next wave is "highly uncertain" and while most modelled scenarios have peaks lower than in January 2021, a resurgence of this scale of hospitalisations "cannot be ruled out".
Given this uncertainty, SAGE scientists have urged the government to put contingency plans in place, ready to respond to soaring hospital admissions that could disrupt the functioning of the NHS.
Hi All
Further to my post yesterday regarding the Herd Immunity, another UK scientific advisor has warned (as reported by Sky News 13 July) that 33% of the population could still be infected by the Delta Variant.
Matt Keeling for the University of Warwick and a member of the Scientific Pandemic Influenza Group on Modelling (Spi-M), backed calls for people to take it slowly when restrictions are released.
He said his team estimates by 19 July there will have been 15,3 million symptomatic and asymptomatic infections in the country which means 27.4% of people will have been infected and have natural immunity antibodies.
After taking jabs – which do not work perfectly – into account, the modellers calculated 33% of the population remains susceptible to the Delta strain.
Professor Keeling said keeping hospital admissions low “and below what we saw in January” relies on individual behaviour. Any “waning immunity” (for example, those with only 1 jab and not yet or refuse the 2nd) could alter the figures pushing up cases he added. He continued “you almost need to think of this like a spring-like system, and, if you suddenly release it, you get a much, much bigger wave than if you gradually let things change”.
Once again, IMHO this report does not consider Delta+, Epsilon or Lambda variants which will make the situation a whole lot more precarious. Other reports have also indicated that nightclubs intend to open across London at 12.01am on the 19 July with some saying they will open for 7 nights in a row until 5am each day – super spreader events.
Oh BOJO what are you doing………
GLA and stay safe.