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So avaca concentrates on STS. But these include a wide range of cancers. So dox is only used on some of these cancers I assume? There fore if avacta wants to go after ovarian cancer as an example is that a separate trial using dox?

Sorry, I am confused as I don't understand why people are trying to assess the addressable market as only what dox sales are. Because surely dox without side effects surpass many other chemotherapies? I just can't get my head around whether dox has to be re-trailed for certain cancer types. I guess I haven't read enough about different chemo and why some are more suited to certain types of cancer. Thank you for anyone's time.

This is what i don't get . Spending many millions on infrastructure without the gas reserves proven. Am I missing something

https://www.gov.uk/government/consultations/10-year-cancer-plan-call-for-evidence/10-year-cancer-plan-call-for-evidence

Alongside improvements in traditional treatment routes, novel treatments such as cancer immunotherapy (also known as immuno-oncology therapy) have emerged. This development has been fuelled by an increased understanding and characterisation of the immune system’s role in cancer. Immuno-oncology is showing significant promise. It involves the development of innovative and targeted therapies to activate the body’s immune system against tumour cells. The Life Sciences Vision sets out our ambition to grow the UK’s global leadership in this area and begin to explore the potential for cancer vaccines by combining our deep expertise in immuno-oncology with the advanced vaccine capabilities developed through the pandemic. Utilising existing infrastructure and successes, we will support industry to commercialise new cancer treatments.

very helpful

Thank you Myles for your hard work, beyond impressive.

Could someone please explain the exact relationship with Bach Bioscience and how revenues would be split going forward?
https://www.bachbioscience.com/
Thank you

many people still don't get just how big a saver-of-life chemo is. That and surgery are still the biggest savers of life never mind all the fancy other treatments. This is an incredible development.

sorry but the market cap suggests we are already miles ahead of a covid company. They need to deliver.I am long here but good news to an extent is priced in. fingers crossed

I can only think the Australian investor here is very confident in the reserves. how Tony has sold this story remains to be seen . It's very hard to push this story without them. That is when the huge upside will be achieved. Has anyone got any comments on what they may have? My limited understanding is we of course have to wait for these drill results.

I was lucky enough to follow Tony Gilby, many years ago when he sold his baby Sunshine gas.i think it was about 800 percent . He is very experienced in coal stream gas and has shares in Comit Ridge in Australia.( coal steam gas)
. This company is now all about having reserves.I wish I were more experienced in assessing this tech but the potential for a huge upgrading of the share in the next 18 months is very exciting. I investment in the power lines before a certified gas reserve is strange and I have been trying to get my head around the confidence shown. the potential for solar and energy storage in Botswana is also, obviously enormous.I am hoping the power line opens further opportunities. Whether TLOU can really nail this, time will tell.How the Botswana Government, with their economy, has let itself become so reliant on SA power is crazy and this will be an enormous opportunity to become energy-independent. It looks like they are backing this finally.Let's enjoy the ride with crossed fingers.

Smashed on this. So annoyed with myself, you try and invest in things that are good for the environment and listen to all the BS. He speaks far too much and, yes lies. I even ordered the skin trust club for my wife, and very average was the response. Nothing about the breath test which doesn't work . The water kits I can only assume have vast competition d he's been given away kits for free thinking he will get big orders that haven't materialized. Out of his depth and a true clown, as am I. There must be some value in modern water but not with this idiot . What happened to the Chinese tie-up? Top 10 company in China. Just blame everything on covid. ( ow, that's supposed to be a market for us). I hold as its not worth selling

trying to get my head around this position, to which I have been battered. The debt I'm told, I called them up is 50/50 with regard to mortgages fixed or floating. So 361 Mio outstanding debt, half is going to go up considerably. Can they put up rents to cover this ... no. The government will start to cut everything. Get better yields almost from govt debt than being here. How can they ever start to realise their supposed NAV ( house price correction underway). This **** pile looks priced in.Am I missing something . Appreciate any help ? I calculate 180mio not fixed , up by 3 percent =5.4 mio pounds less their profit of 44 =38.6 mio . Im sure I'm wrong but it looks priced in for an absolute wreck of assets .trouble is no one trusts the management much or this government who will have to cut expenses . What a mess . I think all bad news priced ut they have to get rent increases . Are they matched to inflation? thnakyou

Most new drugs only pass trials with existing standard of care SOC. So, even if they pass the treatments often involve chemo and resurrection. It's hard to generalise, but many immunology treatments I believe are like this. I haven't got the figures to hand but it's pretty terrifying how much has been spent on cancer trials and how little overall survival has been improved. It's bloody depressing.AVACTA is a potential delivery system and not a new drug as such. Chemo has been the champion lifesaver when it comes to cancer. My hope is that the doctors handling the trials would stop the treatment immediately if it wasn't working . This is their duty, the patients are very sick and need Dox to survive. This is the deciding factor for me and why I have taken a huge risk with these shares. We know dox isnt entering healthy tissue due to increases in the dosage.I think if patients were not improving all treatment would be stopped. The rest is noise .Big binary event. The world will be watching

I don't want to do that but seem to have no choice.....have you met my boys

Could someone explain what is different about what Clovis oncology are doing with FAP please. Or point to a message where its covered. Sorry to ask. I see that is getting a lot of attention on the nasday .
Thankyou for anyone time

Lots of achievements, let’s hope they can keep growing . Can’t see many buyers in this market today , just hoping we have seen a bottom in the share price .??

Just for those that think results have to be spectacular to be approved .

The sobering reality is this: Ninety-five percent of experimental drugs that hit the market fail; the remaining five “might as well have failed,” she writes, as 70 percent of them have “zero effect on survival, while 30 to 70 percent actually cause harm to the patient.”

Of the 72 cancer drugs that hit the market between 2002 and 2014, the average medication prolonged life by a mere 2.5 months.

Full article
https://twitter.com/apwriter/status/1513197927124111365?s=21&t=1RP1vVB7fR7AJzCjl_NVFw

Worth a read . By far the most successful cancer drug / treatment is surgery and chemo
Step in Avacta

thank you

I wonder if someone could help. Been looking at avacta all day.The dose has been escalated beyond the normal amount of chemo? This is obviously very exciting. Am I right in thinking any healthy tissue damage would be very easy to access due to ultrasound?
Could somebody expand on this at all please? and whether I am on the right track
Thank you any time in advance

I am trying to access the

Surely the opportunity there is enormous. Please excuse my ignorance if we are already doing at least something.
Let's hope this loan gets us into some kind of joint deal with one of the majors there.
This then gets re-rated.
Seimens anyone?
I remember years of ****ing in the wind at ITM power. When the big boys arrived as shareholders things started to happen. This is what EQT need I think otherwise its all just too complicated and difficult

interesting to see big moves yesterday in the two graphite stocks I follow in the states
Graphex group up strongly in HK this morning to follow on from yesterday.
and
Syrah (tesla relationship) up to strongly.
Any thoughts on why we so dead here and any thoughts on upcoming catylists thank you for anyones time