Member Info for Shrek1st

Second try at posting this.

Identification of a Single-Dose, Low-Flip-Angle–Based CBV Threshold for Fractional Tumor Burden Mapping in Recurrent Glioblastoma

Aliya Anil, Ashley M. Stokes, John P. Karis, Laura C. Bell, Jennifer Eschbacher, Kristofer Jennings, Melissa A. Prah, Leland S. Hu, Jerrold L. Boxerman, Kathleen M. Schmainda and C. Chad Quarles

American Journal of Neuroradiology September 2024, DOI: https://doi.org/10.3174/ajnr.A8357

Here is the link;

https://www.ajnr.org/content/early/2024/09/05/ajnr.A8357

Shrek

Thanks Max 👍

Hello all,

This article has shown up as Kathleen Schmainda is one of the authors.

Deep Learning Segmentation of Infiltrative and Enhancing Cellular Tumor on Pre- and Posttreatment Multishell Diffusion MRI of Glioblastoma.

Radiology: Artificial Intelligence. 2024 Aug 21:e230489.

doi: 10.1148/ryai.230489. Online ahead of print.

Authors

Louis Gagnon 1 , Diviya Gupta 1 , George Mastorakos 1 , Nathan White 1 , Vanessa Goodwill 1 , Carrie R McDonald 1 , Thomas Beaumont 1 , Christopher Conlin 1 , Tyler M Seibert 1 , Uyen Nguyen 1 , Jona Hattangadi-Gluth 1 , Santosh Kesari 1 , Jessica D Schulte 1 , David Piccioni 1 , Kathleen M Schmainda 1 , Nikdokht Farid 1 , Anders M Dale 1 , Jeffrey D Rudie 1

“ Purpose To develop and validate a deep learning (DL) method to detect and segment enhancing and nonenhancing cellular tumor on pre- and posttreatment MRI scans of patients with glioblastoma and to predict overall survival (OS) and progression-free survival (PFS).

Conclusion A DL model incorporating advanced imaging could accurately segment enhancing and nonenhancing cellular tumor, classify recurrent/residual tumor from posttreatment changes, and predict OS and PFS in patients with glioblastoma. ©RSNA, 2024”.

Here is the link:

https://pubmed.ncbi.nlm.nih.gov/39166970/

Cheers

Shrek

Thanks Onceaday. If you do an image search on the title and limit the results to the last month then the illustrations can be found.

Cheers

Shrek

Good evening,

This review has turned up as a search result.

I haven’t found the full article but this is the title:

Advancing glioblastoma treatment through iron metabolism: A focus on TfR1 and Ferroptosis innovations

August 2024International Journal of Biological Macromolecules 278:134777

278:134777

DOI:10.1016/j.ijbiomac.2024.134777

Matías D Caverzan et al.

I have only found an abstract but it is another positive science paper.

“This review explores the intricate relationship between iron metabolism and GBM, elucidating its multifaceted implications and therapeutic opportunities. By consolidating the latest insights into iron metabolism in GBM, this review underscores its potential as a therapeutic target for improving patient care in combination with the standard of care approach”.

This is the link:

https://www.researchgate.net/publication/383124019_Advancing_glioblastoma_treatment_through_iron_metabolism_A_focus_on_TfR1_and_Ferroptosis_innovations

If I get the full article I will post it.

Cheers

Shrek

And you Tyke.

This has just turned up for a November seminar:

Gallium Maltolate for Treatment of Glioblastoma: Bench to Bedside and Back Again

https://www.mcw.edu/events/biophysics-seminar-series-nov-15

Cheers

Shrek

Hello Max, sorry nothing to report. I was reading about the ASNR / ASFNR AI Workshop next month that the company tweeted about a few weeks ago. Not much else has turned up apart from that.

Cheers

Shrek

Thanks Tyke that gave me a laugh. Yep fingers crossed for a positive outcome here, no idea what will happen but I can hope for the best.

Cheers

Shrek

Morning all, I have been looking at xcures since it’s quiet and I hadn’t heard of them before.

This link takes you to the organisation structure. Or you can just search for xcures and team.

https://xcures.com/company/team/

Anyway Al Musella is part of the team, which I didn’t realise. Good link given his grant support from his foundation.

Have a good weekend and fingers crossed for the footy.

Shrek

😂 no worries Max.

I thought it was a well written piece.

Shrek

Good morning

I found this article during a search. Some information on Xcures that I wasn’t aware of. Here is the link:

https://world.einnews.com/pr_news/724822042/expanded-access-program-for-gallium-maltolate-gam-now-open

Shrek

Hello all, GE have had a restructuring of their imaging business. If it is of interest it’s easy to find with a quick search. Anyway I found this article interesting:

The deep-learning triple threat transforming medical imaging

Kelly Londy

Jun 24, 2024

Here is the link:-

https://www.auntminnie.com/industry-news/article/15678276/ge-healthcare-the-deeplearning-triple-threat-transforming-medical-imaging

This paragraph in particular :

“New innovations in this space will provide insight into images and measurements of the brain that weren’t possible to capture before with conventional MRI, helping to enhance the diagnosis, understanding, and treatment of complex diseases. These advancements in AI and deep learning are not just incremental improvements; they represent a paradigm shift in medical imaging. As boundaries of what is possible continue to be pushed, the potential to transform patient care and outcomes grows exponentially. The integration of AI into clinical practice promises to revolutionize the field, making diagnostics faster, more accurate, and more accessible”.

Anyway it’s a bit of useful background reading whilst it is quiet here.

Cheers

Shrek

Good morning all

This is the link for the proactive video:

https://www.proactiveinvestors.co.uk/companies/news/1050202/imaging-biometrics-shares-promising-phase-1-clinical-trial-results-and-plans-for-phase-2-1050202.html

Shrek

Thanks all,

Plenty to think about. The EAP makes sense as one, the other is the mystery.

Cheers

Shrek

Hello all

This is the link to the news interview embedded in Max’s previous post:

https://www.fox6now.com/video/1464190

Well worth a watch, particularly from 02:30 when the good doctor briefly mentions clinical trials. She says two early stage trials are progressing, any thoughts? I don’t want to jump to conclusions but we do fit the criteria of an early stage trial that has benefited from charitable grants.

Cheers

Shrek

Reported use in another clinical trial.

L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy in newly-diagnosed glioblastoma: dose escalation of the phase I/II GLORIA trial

Published: 28 May 2024

Nature Communications 15, Article number: 4210

This is the link:

https://www.nature.com/articles/s41467-024-48416-9

“All image post-processing and interpretation were performed using IB NeuroTM (Imaging Biometrics), Olea Sphere (Olea Medical), and Mint LesionTM (Mint Medical GmbH) software and assessed by a central reader not involved in the treatment of the patients (SB). MRI response values for all patients can be found in Supplementary Data 4”.

Study locations in Germany

Shrek

Thanks Tyke,

I thought it was just me. I will have a look on Monday regarding voting.

Have a great weekend.

Shrek

Good morning all,

Has anyone else noticed that the AGM notice and details are posted on the company website but haven’t been RNS’d as in previous years?

Here’s the link to the page:

https://www.iqai.ltd/wpiqai/wp-content/uploads/2024/04/2024-IQ-AI-AGM-Notice.pdf

Shrek

Could not agree more Cautious, I have no confidence in the board.

Anyway this might be of interest to those following the research work. Kathleen Schmainda is involved in a clinical trial. Interesting is no mention of IB, just MCW.

Here is the link. If you search for eaf223/gable and filter the results to the last week you get a few results with quite a lot of detail. It does fit in to one of the video presentations when they were discussing future work.

https://blog-ecog-acrin.org/now-enrolling-eaf223-gable-for-patients-with-glioblastoma/

The clinical trial reference is NCT06319027.

Financial results should be week after next, looking forward to seeing the figures.

Have a good weekend all

Shrek

Https://virtualtrials.org/video2024.cfm?video=202403

Shrek