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Thanks Max. Just quickly looked for power life sciences and found one in San Francisco. Seems to be a platform for patients to access clinical trials.
Cheers
Shrek
Hello all
Just found this video posted today. Has anyone else seen it?
https://youtu.be/qKe5TiF49Fw
Cheers Shrek
Hello all,
Mention in this online content. Nothing Earth shattering but coverage nonetheless.
https://patientworthy.com/2023/08/25/gallium-maltolate-pediatric-glioblastoma-orphan-drug-designation/
Have a good weekend
Shrek
Hello all,
Found this journal article during a search.
TIPS-03 A PHASE 1 STUDY OF GALLIUM MALTOLATE (GAM) IN PATIENTS WITH RECURRENT GLIOBLASTOMA (GBM)
Jennifer Connelly, Kathleen Schmainda, Mona Al-Gizawiy, Fernando Santos-Pinhero, Christopher Chitambar
Neuro-Oncology Advances, Volume 5, Issue Supplement_3, August 2023, Page iii34, https://doi.org/10.1093/noajnl/vdad070.134
Published: 04 August 2023
I thought it was a good write up and it includes some information on the dose progression of the study.
“To date, 5 patients received GaM 500 mg/d without DLT and 4 patients started GaM 1000 mg/d.”
I take it that DLT is dose limiting toxicity. If that’s wrong please let me know.
Cheers
Shrek
Hello
I found this article whilst searching.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260053/
HGG-06. CHARACTERIZATION OF THE EFFECT OF THE ORAL IRON-MIMETIC GALLIUM MALTOLATE ON PEDIATRIC GLIOBLASTOMA GROWTH IN VIVO
I can’t see it posted in the recent chat but if it’s already been done accept my apologies for repeating.
I liked the conclusion of the abstract:
“CONCLUSION Monotherapy with GaM provides a significant survival benefit in pediatric GBM, and further studies are planned to optimize the benefit of GaM in pediatric GBM.”
Authors are:
Mona M Al-Gizawiy, Robert T Wujek, Casey J Zoss, Ryuma Tanaka, Shama P Mirza, Christopher R Chitambar, and Kathleen M Schmainda.
Cheers
Shrek
Hello
Just found this article.
https://appliedradiology.com/articles/phase-i-trial-to-evaluate-safety-efficacy-of-gallium-maltolate-for-glioblastoma-multiforme
Good morning all,
This is a link to a recent tweet by Casanova labs:
https://twitter.com/casanova_lab/status/1443276420973842436?s=21
The article they are highlighting is this one- ‘ Pre-existing Autoantibodies Neutralizing High Concentrations of Type I Interferons in Almost 10% of COVID-19 Patients Admitted to Intensive Care in Barcelona’ published in the Journal of Clinical Immunology.
If you read the thread it links to further supporting findings.
If the article has already been posted I apologise, however what interested me is the coverage by Casanova labs.
ATB
Shrek
Hello all, found this in a search.
Date Published: 30/07/2021
Cadiz hospital trials new Covid treatment in international study
The Puerto Real University Hospital, Cádiz, is the only centre in Andalucía to participate in the trial.
The Infectious Diseases Unit at the Puerto Real University Hospital in Cádiz is participating in an international clinical trial exploring the efficiency of a new treatment for Covid-19.
Hospitals and medical centres from 12 different countries are participating in the trial, including 11 Spanish hospitals, of which only one is in the Andalucía region.
The study is a double-blind RCT (randomised controlled trial) which aims to prove the effectiveness of the use of inhaled interferon beta 1 in mild-to-moderate cases of Covid.
Interferon beta 1 belongs to a type of medication called immunomodulators, which is frequently used in the treatment of multiple sclerosis symptoms as it decreases inflammation and prevents nerve damage.
This medication will be applied to coronavirus patients using an electronic device that nebulises the drug and allows it to be inhaled.
Since its creation less than a year ago, the investigation department of the Infectious Diseases Unit at Puerto Real Hospital has participated in seven clinical trials; four about Covid-19, one about HIV and two about antibiotic resistant bacteria.
Representatives from the hospital have stated that this opportunity allows the rising number of coronavirus patients in Cádiz to be offered a promising treatment for Covid that isn’t available anywhere else.
Here is the link https://murciatoday.com/cadiz-hospital-trials-new-covid-treatment-in-international-study_1624167-a.html??region=381
Shrek
Thanks to Google translate this is the text:
Phase III, randomized, double-blind, placebo-controlled trial to determine the efficacy and safety of SNG001
inhaled for the treatment of patients hospitalized with a moderate form of coronavirus disease 2019 (COVID-19)
Good evening, I have been looking for information about the progress in other countries and have not found much.
This looks like a list of clinical trials in France and they are using the SPRINTER term for us. Also the Paraxel contact is given: Aurore.Moreau@paraxel.com
I haven’t found anything else yet.
Here is the link.
https://solidarites-sante.gouv.fr/IMG/pdf/covid19_projets-recherche_therapeutiques_en-cours-instruction.pdf.pdf
ATB
Shrek
Just found this, if previously posted apologies.
https://www.evaluate.com/vantage/articles/analysis/spotlight/big-covid-19-trials-still-report
Shrek
Good morning, a bit more coverage of activ2.
https://homelandprepnews.com/stories/63549-niaid-activ-2-trial-begins-phase-2-3-testing-on-four-covid-19-therapeutics/
ATB
Shrek
Apologies if this has been posted.
https://www.nih.gov/news-events/news-releases/four-potential-covid-19-therapeutics-enter-phase-2-3-testing-nih-activ-2-trial
“The first volunteer enrolled in the SNG001 sub-study on February 10. The other agents under study are expected to begin enrolling participants soon”.
Shrek
Good morning all. Not sure if this has been posted but a nice mention in the article.
https://www.miragenews.com/four-potential-covid-19-therapeutics-enter-513736/
ATB
Shrek
Evening all, just found some coverage in Greek media during a search.
Here is the link https://newpost.gr/ygeia/5fc3fd93e24d0a862437561f/koronoios-ayto-einai-to-farmako-poy-ayxanei-tis-pithanotites-anarrosis-asthenon-poy-nosileyontai
Positive coverage, google translate is my friend. I liked the title of the article.
“Coronavirus: This is the medicine that increases the chances of recovery ...”
Atb Shrek