Member Info for sadoldgit

Hi Hellme12. Go to the following link and look up description. SDC 1801 does not really have much correlation with DNA.
SDC1801 controls down signalling by regulation of different interleukins, interferons with regards to type of cell production eg CD4 helper cell and CD8 killer cells ( not to be confused with NK ( natural killer cells) Control of inflammation and apoptosis ( programmed cell death) in this case extrinsic pathway.

https://worldwide.espacenet.com/patent/search/family/047754367/publication/EP2634185A1?q=pn%3DEP2634185

( look up description)

Originally posted by Krone a while back. Worthwhile looking at and getting your head around.

Regards

AGILE is a UK phase 1 and 2a clinical trial platform designed for rapid clinical evaluation of potential COVID-19 treatments

It is a collaboration between the University of Liverpool, the University of Southampton Research Unit, and other external partners

The innovative design of the trial means that multiple potential treatments can be evaluated in parallel and important testing stages can be completed in months rather than years, while maintaining a high level of safety at all times

Patients in early stages of COVID-19 infection will be recruited to AGILE from the community, in addition to patients who have been hospitalised with COVID-19

Treatments that show a signal of benefit in AGILE will be rapidly considered for advancement into later phase clinical trial platforms, such as PRINCIPLE and RECOVERY, where the effectiveness of treatments can be proven in greater patient numbers

The Therapeutics Taskforce will work with innovators to support them to progress their promising treatments through clinical trial phases

4 treatments have so far been selected for AGILE:
EIDD-2801 (Molnupiravir), an antiviral
VIR-7831 and VIR-7832, both monoclonal antibodies
Niclosamide, an anthelminthic
Future treatments to enter AGILE will be selected by the UK COVID-19 Therapeutics Advisory Panel (UK-CTAP), who lead the process of reviewing and evaluating proposals for treatments to enter UK national trial platforms – read more about UK-CTAP and how drug proposals can be made

The UK was the first in the world to find a treatment which was proven to significantly reduce the risk of death: dexamethasone, found through the government-funded RECOVERY trial

On Thursday 11 February, RECOVERY also found the drug tocilizumab, when administered to hospitalised patients on oxygen with dexamethasone, further reduces the risk of death by 14% and length of hospital stay for patients by 5 whole days, on top of the benefits of dexamethasone – which will mean once rolled out to patients will significantly reduce pressures on the NHS

REMAP-CAP, which also received government funding, last month published results showing tocilizumab reduced the length of time in hospital by 10 days when administered to patients with 24 hours of being admitted to intensive care

Funders
The AGILE Initiative is made possible thanks to support provided through a variety of donors. In addition to funding provided by Unitaid and the Steve Morgan Foundation, some candidate-specific trials will be funded directly and solely through companies (for example, Ridgeback Biotherapeutics, Glaxo Smith Kline, Vir Biotechnology). Collaborative financial support has also been provided by the Liverpool School of Tropical Medicine, University of Liverpool, and Southampton Clinical Trials Unit as well as the NHS (Liverpool University Hospitals NHS Foundation Trust).

Interesting to see Glaxo there with a 100 billion dollar market cap.

Interesting Citizen 79. In effect we have a Tyk2 Jak 1 inhibitor that has shown to down regulate the cytokine storm. This implies a stage that administration of an inhibitor is appliied post infection of Covid19. Ie after infection but before severe damage is done to our respiratory systems.

However. What l believe is being inferred here is an alternative to a vaccine. It would not be beyond belief although am a little sceptical that an morally taken compound could be taken not to prevent the infection of Covid alone but to severely restrict the damage it can do to our bodies. Why wait for someone to get on their deathbed so as to speak when maybe a Jak1 Tyk2 or Tyk2 Jak 1 inhibitor would prevent or limit the severe side effects of Covid. Not have to worry about mutations either.

Only concern for me would be people who are not affected by Covid 19. How would a preventative medication affect them.

Truly and absolutely mind boggling if this were the case
Report coinciding with our expected completion of investigative research end of month.

May be barking up wrong tree, and a stupid old git as opposed to sad old. Food for thought though.

Regards and perhaps the one or 2 a day pill you referred to a couple of months ago is most certainly not to be laughed at or ignored.

Have a good day citizen79
Regards. Your posts make visiting this board a pleasure.

Looks very promising, basically Jak1 and Tyk2
Presumably Jak1 and Tyk 2 referral infers main target Jak 1 and secondary Tyk2.

Thanks Citizen79

Plans for micro brewery extra capacity already HBD, I am sure Tim would let us use the word Sareum in return for as much beer as he wants.
Busy day at work tomorrow 7 to 7 so not able to look in here much. On the good side will miss the c..kwombles.
Regards

Regards.

That should be Blastoid and Bobbler. Apologies.

Blastoid and Bobbler good name for a beer too

Regards to both of you

Wow that is damned fine idea you have there Bobbler. You will have me looking at the costs now.

Covid ale 1801.
Tims Tipple
The Millionaire Maker
10 out of 10
The Inhibitor.

Regards.

Slyhuntress. You are not invested here.

your previous post

'probably best to wait unti that 2.8 buyer has sold out or sell before they do

I cannot see pounds for starters we have over 3 billion shares, and i suspect that would make any who bout at 0.25p multiple millionaires times over'

How can you put 'we' as that indicates part of. You have no shares

My average is not 0.25p but not much higher at less than 0.5. I am not selling any until it reaches the dizzy heights that the new, and ill informed don't have the mental capacity to comprehend.

You want to make a reasone discussion on this and use your LSE right to reply then please do. you are onto a loser before you even start.

I am not blocking you either. Even the dumb and the ignorant have a right to be heard'

Regards and have a super evening.

Prediction of the most important of red dot ie entry to Agile confirmation, Monday July 19th.
Anyone else like to hazard a guess as is all it is at the moment.
Regards

Good afternoon Celtic007. My belief is the crystallisation of a compound with Our SDC1801 and 1802, should make manufacturing in large quantities if required so much easier. Clearly Tim was aware many moons ago and now this problem would appear to be resolved.
I may be wrong but I can see no reason why this cannot be applied to our Aurora FLT+3. My opinion of the Aurora deal, is the Chinese were looking at it for a possible treatment for Covid 19. The pharma involved very hush hush. Many of our competitors are using similar targeted indications in an effort to get their product into the multi million dollar revenues that will result from prescribed treatment for covid19. My opinion for what little it is worth is they are barking up the wrong tree as being proved by the very limited positive effect of supposedly neutral clinical trials.

Interesting to note that the Chinese are developing a Tyk2 inhibitor with regards to Covid 19. More to follow on this later

Aurora plus FLT3 unlikely to be significantly effective against covid 19. It is an oncology treatment (primarily for AML) and not immunotherapy. CD135 is a proto-oncogene, meaning that mutations of this protein can lead to cancer. Mutations of the FLT3 receptor can lead to the development of leukeamia, We are looking at a completely different target here than Covid19 although true to say FLT3 is a cytokine receptor. Albeit in most of the wrong areas for Covid.

However, Sareums main focus will definitely be the on license of SDC1801.

From Jan 8th 2021

Sareum’s CEO, Dr Tim Mitchell, commented:

“We will review the data and progress made with the programme by our Chinese partner over the coming weeks and will evaluate options for re-partnering the FLT3 programme. While early studies with our FLT3+Aurora kinase inhibitors were promising, formulation continues to be a challenge. Our clear priority focus remains on advancing our proprietary TYK2/JAK1 programmes and, in the near-term, on completing the preclinical work needed for the first Clinical Trial Application during the first quarter of the year. Achieving this important milestone will be a key step in generating shareholder value from our TYK2/JAK1 pipeline.”

This announcement contains inside information for the purposes of Article 7 of Regulation 596/2014.

That is about as much as I can offer Celtic007.
Regards and have a good day.

https://economictimes.indiatimes.com/news/science/covid-19-delta-variant-may-breach-vaccine-shield/articleshow/83889378.cms

No surprise here.

Thanks for digging that RNS out Ahfam. As you correctly state it is still available for license ( Sareums crystallisation of compounds I would hazard a guess would resolve the solubility issues. Very good ADME properties with that too ie absorption, distribution, metabolism and excretion.

Regards

Good morning Stevej. From memory the then talked about 10p price per share ( and party to follow) were when Aurora + FLT was considered sareums jewel in the crown. The results then of the 10 out of 10 mice with greater than 98% tumour reductions ( so incorrectly referred to now as 10 out of 10 mice cured) and it was around mid 2013 when Sareum had circa 1.2 biliion shares in issue. Concerns gathering then ( only slightly) around raising of funds and share dilution.

Regards

Ahfam. I think you are correct. Agile will open the doors. In a sense it will remove doubt. As has been mentioned before it will put Sareum into the driving seat as they can sell or license on their terms. No bullying and knock back prices on the 'played element of doubt' by the pharma's. Many will not have the money to stomp up front. Takeover at the moment or particularly at later stage into a treatment, and there is not a pharma can afford to pay. Soon as a formal bid is made then believe me, unless mighty it will be outbid by someone else.
People at one time ie some of the shysters who appeared on here saying sareum are too late. Far from it they have hit it bang on the right time. Compound being going on for over 8 years then you get a prize one say. ' it takes 10 years' , nigh 9 years of passed so they dont leave much time.

I ain't ramping or deramping. The true worth apart from the saving of human lives is the amount a pharma can make at the end of the day. Present treatments apart from being costly about as much use as a handbrake on a canoe.

Regards

Slyhuntress, Change your attitude slightly and you will most likely gain.
I will add that most don't like trump supporters or people that are right wing and and will likely block you. But then look at it again they have done you a favour as not have much to offer.
Just be honest in your approach and dont blurt out things you cannot substantiate. All like to make money here after all.
Regards

Just look at this lot. Desperation comes to mind

https://www.theguardian.com/world/2020/aug/24/six-of-the-most-promising-treatments-for-covid-19-so-far

Why the hell bother with lockdowns in the first place? The mind boggles!

Did he really have an option or was it orchestrated? You prediction is correct Danny. Scapegoat mentality. Remove the mouthpiece and remove the problem. I am sure he will maintain his full pension and already a new career awaits him.

Steadydanny. You are not a crackpot by any means. As we get older we get educated and indoctrinated.

You have hit a proverbial nail on the head with msm. We are told are version of what they would like us to hear. It dont mean we will get the truth. Truth being factual information as opposed to a biased form of interpretation in this respect.

I will not put some info up on here I have access to. End of!

Just look at the early stages of the Chinese carrying out measures to control of the virus. Most now wiped from existence.
Big lorries spraying 3 lanes of roadways at Wuhan.

the virus will create cytokines in a proportion of people. If we can control the cytokine storm we can limit mortality. Even in mild cases the Covid will damage organs in our bodies. What then happens to people who have contracted the virus twice? Are they immune from catching a third time? Hell no. There will be a very small percentage of people who will pass unharmed.
AS regards to conspiracy fauci was funding Wuhan in 2017 with no consultation with the white house. Reports I have seen is China in 2015 were looking at 3rd world war as biological war.
It gets very political and way beyond this Sareum chatboard. The information is there so are the frightening realities. Just dont post as will get removed along with freedom of expression.
As I have said before very sinister time where the government which at the end of the day controls what information they want you to hear.
Good day to you sir. perhaps meet up at the 10p party which i believe Andythemkdon was looking forward to 9 years ago when we had circa 1 billion shares. 30p should be the price I think as we stand now.
Regards and have great weekend lad.

That is good BlackisleBoy, I am genuinely pleased for you. Sit back and enjoy the ride. Those that slate are not invested. They do not want to enter on a spike either, hence why they will deramp. They also have very little idea what little Sareum have.

Regards