RE: Great dus31 Jan 2021 14:15
Hi WTP.
I'm not sure there's much to expand on but I will give it a go.
We have the issue of 1st gen vs 2nd gen vaccines. I think the overriding objective of the 1st gen vaccines was speed. They achieved that and in the process managed to get good efficacy as well. Why would 2nd gen vaccines take longer? Well, they wont necessarily, but, there is little point rushing out a second generation vaccine that is only as good as the 1 gen vaccines already out there. Better to take the time to get better efficacy, longer lasting and be effective against future variants.
The second issue is Scancell's 2nd gen MK1 vaccine (SN14) vs their 2nd gen MK2 vaccine (SN15). It has been some time since we were told that SN14 had been selected as the preferred candidate. Presumably since then a lot of effort has gone into developing/testing SN14. his work will have to be done again for SN15 don't you think?
It wasn't long ago that LD was extolling the virtues of SN14 and using a Modified-Fc. SN15 uses a Monomer rather than Modified Fc. So it's not as cut and dry as some may think. Have a look at the excellent link Miavoce posted earlier, 28 minutes in.