Member Info for RuckRover

Ivy, now you have lit the blue touch paper I hope you have taken a few steps back lol.
I can hear the steam hissing from the keyboard now.

I also have O level chemistry and physics but no real world experience like you.

>because Lindy cannot announce homocitrulline because of the patent <

who is Lindy .........

again if you want to promote the share why are you taking such short cuts ? any one reading would not have a clue

those in the bubble are talking to themselves

Ipad, LOL.

Cause I gotta feeling, woohoo
That this week's gonna be a good week
That this week's gonna be a good, good week

Morning Inanaco,

Didn't really get the operating system analogy. Perhaps I'm biased, I think windows is the worst commercial software I have ever come across not something I would want spoken of in the same sentence as Scancell. Perhaps Mac OS, VMS or even Linus would be a better choice?

Did you mean some sort of pattern recognition software?

Morning C7, double figures by the end of the week then.

If the technology overlaps, Scancell will need to licence it from NU then. Any reason why NU wouldn't licence it to other Pharmas/Biotechs?

Ray,

Did you know that Prof Durrant is named ion 18 patents?

There was one on Glycans submitted in 2013.

Morning C7 et al,

Yes, a great analogy by Ciaskin, and good to see other posters pick up the baton and run with it!

I haven’t commented on the AGM feedback but your observations have prompted me to do so. Just a couple.

The CH comment that near to short term is “relative” is technically correct. An absolute time frame would be 15th December or Q1 2019. Short term could be longer in a biotech than another industry. So unfair to call it glib (just my opinion)

The USA connection. Every company I have been involved found the USA very challenging and a hard market to crack. Whilst it is hard to see the value right now, I think the USA connection is a necessary one for Scancell to realise the full potential of the science, medicine and commerce.

AIMVHO

Post crossed again lol. Goodnight

C7, what are you doing up, wat past your bedtime!
Funny that we posted at exactly the same time.
Today was a good discussion, I learned a lot and hopefully others did to. It was great that so many contributed.
ATB

Farmer, I see you’ve not been paying attention today. You need to spend a wet afternoon understanding the science, you’ll soon change your tune.
To late to bail out now either the engines will fire up or we hit the ground (not running)

From the poster kindly posted by wild:

"Our research suggests that the citrullination of peptides in rapidly growing tumour cells may be exploited to generate specific CD4 responses which lead to tumour rejection."

Isn't that a T-cell response following the introduction of the citrullinated peptide?

Ray,

"Then if the memory cells already exist why does the cancer establish itself?
As part of clonal expansion of the tcells, some become long living memory cells."

I missed that bit "clonal expansion"

That would suggest it does increase the number of cells?

Inan,

But noises' statement is essentially correct (even though Prof Durrant has not put it like that herself)

I think this is probably the most sensible discussion we have had in a long while, contributions from a number of different posters. It is a discussion of fact rather than opinion so we should eventually reach the same conclusion given enough time.

Ray,
"I think you will find that Lindy's Moditope mouse experiments exhibit a memory response"
True, but:

The memory could be stored in EXISTING T-cells rather than new ones being produced?
The memory could be in the B cells possibly.

Ray,

"Both moditope and immunobody cause the production of memory T cells "

I don't think Moditope does.

Konar, that's shocking, the guy is supposed to be an MD and he has nicked Inan's post!

Inan,

Your last post:
…………………………………………………..
Moditope is NOT killing the cancer ......
Moditope is NOT modifying t cells in any """synthetic""" way

Moditope is setting off a NATURAL IMMUNE RESPONSE
……………………………………..

That's pretty what noise (and everyone else) has been saying original post:

so MODI1 is a mixture of natural(ish) citrullinated proteins, delivered in the hope of overcoming the tumours local immunosuppressive environment, spurring a natural T cell attack on the tumour.

Inan,

The question was:
"Does moditope increase CD4 T cell count?"

Does it?

Inan,
"Then why don't they ? CD4's will already be in the area "

I don't know why. I don't know if they do or don't (increase). My understanding is that moditope is about getting T cells to attack the tumour through better recognition rather than increased numbers.