Member Info for RuckRover

I meant to say:

whether the change causes (not caused by) citrullination or whether citrullination causes the change.

Noise,
I don't think you are that far out.

"Is a simplified explanation that citrullinated peptides appears to drive an immune response with increased CD4+ T Cell count"
Yes, it improves the immune response as the CD4 T cells seem to want to attack it. I don't think it increases the T cell count.

"MODI1 is a mixture of natural(ish) citrullinated proteins"
They are citrullinated peptides.

"delivered in the hope of overcoming the tumours local immunosuppressive environment, spurring a natural T cell attack on the tumour. "
Yes, but I wouldn't say "in the hope of" I think it is a bit more scientific than that.

"Citrullinated being a -NH3 branch on the peptide, changing the electromagnetic polarity of the peptide?"
The polarity of NH changes from positive to neutral at some point. I'm not sure whether it is this change that is caused by citrullination or whether citrullination causes the change.

For a better explanation have a read of Lindy G Durrants report -
"Autophagy, citrullination and cancer"

douve, do you expect to retire in the near to short term?

lol.
Do you know that for a fact?

cyn,

How can it have a P/E of 4.42? SCLP are making a loss not profit.

Ray,
Big difference between KNOWN and POSSIBLE don't you think?

Inanaco,

You make some interesting observations.
Just one small correction:

> all the possible delays to trials identified and being sorted<

There has been an issue with the FDA/Trigrid device identified and as far as we know it is being sorted.

I don't think we can say ALL POSSIBLE delays have been identified in ALL trials can we?

Was hoping for something a bit better than this, something to get us back to 10p at least!

I agree with ivy, krafty, ONW (on ADVFN) that Scancell need help. The commercialisation and financing are unable to keep up with the pace of scientific research and discovery.

1stTee - welcome, I hope you make it to the 18th.

Well your prediction was spot on C7!

That’s a naive method.

Prediction (forecasting) has 3 elements:
1. Past history
2. Probability
3. Intelligence

Just because the site has crashed does not necessarily mean it will crash again.
You can work out the probability of it crashing by looking at the mean time between occurrences.
However, you may have intelligence (inside information) so if the cause of the crash was a faulty memory card and it has been replaced, the chances are it won’t crash.

Sorry crumbs, did I miss something?

Inan,

No .. soldiered on until i had proved my case .. remember the 7 trials debate ! even won that one thou it took a month

I am aware of 3 trials:

SCIB1 Combo (delayed by FDA queries)
SCIB2 CRUK sponsored
MODI1 (planned 2019)

Are you talking about planned trials or POTENTIAL trials? If you are talking about about potential trials then you may as well say 20 to include things that haven't been discovered yet.

Ray,

Just to add:

The science is good enough for big pharma for the level of investment they have put in.
The science is good enough for the market as indicated by the share price.

As far as the latter goes, it may well be down to lack of understanding (of the science) but that can hardly be said of the former can it?

Ray,

Your question to agema:

"Perhaps you should explain your doubts about the science not being good enough.
Alternatively, if you think the science is good enough, again explain why."

I think the point is we just don't know yet. There is a long way to go before it is "proven" - lots of trials and perhaps a deal dare I say!

All I can say is, that the science is good enough for me for the level of investment I have put in.

Inan,

"Agema ... you appear to be alone in your observations "

Not alone, I agree ONW was and is a balanced poster and makes some valid points.

>I can give you an enormous list of reasons to buy and hold …<

1. You bet a friend you could lose money quicker than him?

Ray, your comment:

"The "bright side of life" is the science. "

I'm sure I remember Betamax saying "our superior picture quality and capacity will see us through"

Struggling to find a bright side at the moment. Perhaps one will appear when the sun comes up tomorrow?

Ray, it was KF who used the term “compelling” and then later picked up on by RG. It’s no good saying it isn’t compelling enough for big pharma, it IS compelling according to one of the most respected consultant in the field.

It is up to SCLP to ensure the data is even more compelling to big Parma and do whatever it takes to achieve this. Starting the trial on time would be a start!

The POTENTIAL of modi n will become irrelevant unless something is monetised. One of (the many) risks is that SCLP will be sold cheaply on the valuation of validated science (SCIB1) with big pharma progressing modi for their own financial gain.

Ray, you have to bear in mind that SCIB1 has ALREADY produced “compelling data”. This is the platform that could produce revenue first either by selling it, licensing it or funding it all the way to market.

Every new discovery by the Scancell research team whilst extremely exciting and potentially game changing is yet another drain on the limited financial resource of a small biotech.
IMHO

Inan, perhaps the AGM isn’t the forum to question the science. Maybe someone could ask if they could arrange an investor day to discuss the science in detail and allow questions to be asked.