Not understood6 Jul 2021 21:45
Today's RNS is very interesting. But even with a biological background I confess I didn't understand it very well.
But there's an incredibly big sentence in here. "This demonstrates not only the importance of Live Biotherapeutics as a new modality poised to revolutionize the treatment of a wide range of cancers [WOW!], but also the power of our MicroRx platform to continue making significant discoveries and advances in this field."
It's easy to gloss over the identifying codes, such as this one MRx1299. Looking in the final results it doesn't get a mention. So it's a new one? And just what is this MicroRx platform??
I found this "Pipeline" page on 4D's website very useful
https://www.4dpharmaplc.com/en/developing-science/pipeline
"Through our understanding of the functionality and interaction of these bacteria with the human body, Live Biotherapeutics developed by 4D pharma have the potential to treat a large number of diseases.
Each of our programs is underpinned by a different Live Biotherapeutic, and each operates through a variety of different mechanisms. Using MicroRx® , we are able to gain an understanding of how our candidates impact the human body at the molecular level. This allows us to more effectively target diseases for intervention with our Live Biotherapeutics. Additionally, using MicroDx, we can assess how those candidates impact the host microbiome.
Using MicroRx®, we have generated a suite of development programs in diverse therapeutic areas including immuno-oncology, GI, respiratory, autoimmune and CNS disease."
In the schematics on the page you'll see 14 different therapeutic areas they are applying LBPs to - all of them massive - using 8 different LBP's, plus Blautix and Thetanix, for IBS and Crohn's respectively.
MicroRx points the way to the bug for the disease: rather than relying on good old incredibly long and expensive (and failed).... trial, error and luck.
I do recommend a good look at that page. It's almost scary.
Finally CAR-T. What on earth? According to NHS England: "CAR-T is a highly complex and innovative new treatment. CAR-T is a type of immunotherapy which involves collecting and using the patients’ own immune cells to treat their condition."
And: "CAR-T – chimeric antigen receptor T-cell – therapy is specifically developed for each individual patient and involves reprogramming the patient’s own immune system cells which are then used to target their cancer. It is a highly complex and potentially risky treatment but it has been shown in trials to cure some patients, even those with quite advanced cancers and where other available treatments have failed."
So it's sounds like the most advanced personalised treatment for killing cancers, and our LBP enhances it.
And the MicroRx platform told them it would.
Yes!