RE: $3 Billion Per Year21 Mar 2026 10:05
@hamila01
Agree. On the subject of Type 2 diabetes, I wrote to Lisa on 8th October, copied below:
Good evening
I have one question for Tim please. I was researching whether diabetes, both Type1 and Type2 were autoimmune conditions and, if so, whether P140 could potentially play a role in the fight against these conditions.
On carrying out a search on AI, I have found the following summary:
TYPE1 DIABETES
Cause: The body's immune system mistakenly attacks and destroys the pancreatic beta cells that produce insulin.
Nature: It is a classic autoimmune condition where the immune system is attacking the body's own cells.
Confusion and Overlap
Latent Autoimmune Diabetes in Adults (LADA):
Some people initially diagnosed with Type 2 diabetes actually have LADA, a form of autoimmune diabetes that develops in adults. These individuals have autoantibodies in their blood, similar to Type 1 diabetes.
Inflammation: The role of inflammation is a complex area of research, but current understanding points to Type 2 diabetes being a metabolic disease, even though immune cells and inflammatory responses are involved.
Adults Over 30: LADA typically manifests in adults, differentiating it from the pediatric onset of classic Type 1 diabetes.
Individuals with a Type 2 Diabetes Phenotype: Patients initially receive a diagnosis of Type 2 diabetes because they don't require insulin at the onset and may be managed with oral medications.
People with Autoimmune Markers: A key characteristic of LADA is the presence of pancreatic autoantibodies, such as glutamate decarboxylase autoantibodies (GADA), a hallmark of Type 1 diabetes.
Individuals with Other Autoimmune Diseases: There is a strong association with other autoimmune conditions, particularly thyroid disease.
Geographic Considerations:
While LADA is a global condition, prevalence estimates can vary by region.
North America and Southeast Asia: have shown higher prevalence rates in some studies.
Studies in China have also identified significant numbers of patients with LADA among those diagnosed with Type 2 diabetes.
Key Takeaway:
LADA is a progressive autoimmune form of diabetes that occurs in adults, often initially misdiagnosed as Type 2 diabetes.
Recognizing LADA is important because these patients will eventually become insulin-dependent.
It seems from the above AI summary that both Type1 diabetes and LADA (which is confused for Type2 diabetes) are both autoimmune diseases and P140 could have a role to play in the fight against these conditions.
I would be grateful if you are able to please provide your view on the above.
Many thanks
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