RE: Val20127 Feb 2023 13:30
It works:
Surprisingly and unexpectedly, the inventors have now demonstrated that targeting the SH3 domain of the tyrosine kinase, Src impairs the metastatic phenotype of fibrosarcoma and prostate cancer cells. The inventors have found that a peptide that binds to the SH3 domain of Src inhibits EGF-mediated processes known to be collectively involved in metastasis, such as DNA synthesis, motility and MMP secretion (see Example 1), and significantly reduces the incidence of lymph node metastases (see Example 2). Given that cell motility and MMP expression are known to be involved in metastasis (Jung et al, 2010; Cortes et al, 2008; Murray et al, 2012