Member Info for PL75

Consider the limitations outlined in my last post. Then consider over coming them using Avacta's platform. The market for inferior ADCs is already BILLIONS. Things might start to get very interesting.

Or, for balance, they might not. Just to keep the misery doom spammers happy.

Thanks LLnP.

(https://pmc.ncbi.nlm.nih.gov/articles/PMC10208276/)

An approach toward obtaining longer-lived TOP1i that actively target specific tumors is to incorporate them as payloads in antibody–drug conjugates (ADC). Indeed, three ADCs containing TOP1is—the Trop2-directed sacituzumab govitecan (Trodelvy) delivering SN-38, the HER2-targeted trastuzumab deruxtecan (Enhertu), and Trop2-directed datopotamab deruxtecan delivering a close derivative of Exa—show impressive results in the clinic and have been approved (13). However, most tumors do not have the Trop2 or HER2 surface antigens recognized by these ADCs, and are thus not suitable targets for these tumor-targeted agents. Likewise, ADCs cannot specifically target subsets of a tumor that differs from others in a TOP1i DDR defect, such as BRCA or ATM deficiency. Thus, a need remains to develop long-acting, tumor-agnostic TOP1i prodrugs that do not require the presence of specific tumor antigens to express their antitumor effects.

Enter ava6103.

Guess it’s the AffDC candidate

Hurst, stick to what you don't know. Wonder who 'us', 'our' and 'we' are. Now you're attracting green boxes you're in the fluffer camp you moron. You claim to be a contributor. Struggling to see a single contribution of any value ever since you turned up.

Timster, hope you're proud of your baiting. It was better when it was white noise than the lairy twat we have now.

At least 14 months of it. Any more predictions Hurst? Nail your colours to the mast so you can be held to account for the tripe you spam.

Post gibberish about bagels. Stick to what you don't know.

Which IPO? This year or the last one from Aug 23?

Yeah. Posted on 1st August 2023. Muppet.

Two hottest IPO’s this autumn:

Avacta and Birkenstock, major houses will be fighting to get the ticket for the deal.

Aug 23. The same drivel. IPO on the way.

Size buying purple rain singer eating bagels

I’ll believe it when I see a brochure.

Anyone remember the good old days when he'd just type gibberish in his own unanswered threads? Pretty sure we can recapture the magic by ignoring him. It's just white noise... Size buyers.. NY... blah blah...

Cash, otherwise what was the point last time. They'll be anticipating plenty cash from the sale of Dx I'd have thought. Plenty money in the bank for at least 18 months if they get a sensible price for it

Chris has a massive pipeline full of goodies.

Just 16 more days of 11% and we’ll be a all time highs

Insane. Also now binned.

BV, if anyone believes Hurstbot, they'll be getting what they deserve

No one does. Harmless pointless white noise. Just ignore it

So there’s a chance we’ll see an exodus of the miserable old ghouls that haunt this board? No downside for me, although once I’m a billionaire thanks to £200 exc chin-ah I’ll need to think a bit more about inheritance rules.

There you are pd.

How would listing on Nasdaq solve a uk inheritance tax change?

“c.£32.5m cash-in-hand at end-June 2024 stage, together with expected net proceeds from disposal of the Diagnostics division (for which credible indicative offers have already started to be received with further bids anticipated), should provide sufficient runway to complete AVA6000’s Ph.2 study along with development of pre|CISION™’s next generation programmes.”