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44 mins ago.......
hTTps://www.dailymail.co.uk/news/article-8199477/Swedish-hospitals-stop-prescribing-chloroquine-coronavirus-patients-adverse-effects.html
Another view to consider ??
It occurred to me, that there was potentially another trial outcome which I wasnt sure had been mentioned here ?? That being, if the trial yielded a mix of results eg it was efficacious in "kick starting" the immune response in naturally lower beta interferon Pt's ( those more at risk it seems of serious disease)BUT didnt really lower viral load much. Many conditions are treated with a combined therapy plan either for their independant actions or to work symbiotically. For example,if the above was true, the addition of another drug eg Ritonavir (antiviral) might together achieve a beneficial outcome.
Just to mention for discussion, as even if SNG001 wasn't THE cure, in combination with other drugs, it might still be a valuable resource against COVID 19 ( or others ). So while I take the point that in terms of SNG001 efficacy as a singular drug in this trial against the COVID 19 is a binary type of outcome, it may not be a binary event for SNG001 or Synairgen ?? The next rapid phase could be looking at combining trials for their respective benefits maybe....others with a pharmacology background will know much more here.
Who knows, but thought worth bringing up as felt we might all be seeing the trials as Pass or Fail ?? This might not be a race for a miracle drug.....it might be drug"S". Just my view here ..
The recovery trial website interestingly lists the inhaled beta interferon as one suggested treatment option, but then states in brackets next to it, that its not in that trial. Its certainly on everyone's radar as the letter from the 4 CMO's asking for as many referrals for all tests as possible, also has it on a web link under "other priority studies" and it's there. Interested to know why it didnt fall into that trial since they listed it ? Likely that eg. trial criteria didn't fit etc etc , but Im interested to know if anyone has the facts ??
As it’s not trialed on COVID 19, only some other viruses I don’t think they know ? I think it partly measures viral load and bodies reaction from comparing ( daily ?) sputum tests.... time will tell, let’s hope it helps
Thx xyz,
"To boost the potential effectiveness of ritonavir and lopinavir, one trial is testing a combination of those two drugs and interferon-beta, a compound doctors use as first-line therapy in the treatment of multiple sclerosis.
The trial — called MIRACLE — is currently testing this experimental treatment with the consent of MERS patients.
Yet another upcoming trial — supported by a U.K.-based pharmaceutical company and not part of the WHO effort — aims to use a specific formulation of interferon-beta on its own in the treatment of COVID-19.
“The idea behind the trial is that, by giving more of this molecule to the lung, this could help reduce the severity of infection with COVID-19, especially in those people who have reduced immune responses to the virus,” explains Prof. Ian Hall from the University of Nottingham in the U.K. Prof Hall is not associated with the upcoming trial." - Cohut, M . (2020) Extract from article 26.3.20 Medical News Today
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