Roundtable Discussion; The Future of Mineral Sands. Watch the video here.
To me, "at home" use is where SNG001 sits perfectly in first strike use. Excellent news that this can be trialled here and in the timeframe window and candidates that SNG wanted. Hospital trials were needed first, not least to assess safety in CV patients and not really possible to take blood or sputum samples in home trials.
A person could ring 111 /GP when they start to feel unwell,get a phone provisonal diagnosis and if their Mhistory /age etc puts them in "at risk" group, they are sent out / pick up a quick CV test ( fingers crossed soon ) for "at home" use. If positive, they then start immediate use of SNG001 via further phone /other links provided either by delivery or collection. They are then monitored remotely as in the trials.
This could possibly prevent a large % of the hospital admissions....it would also address spreading the virus ( or any other )
This process might also be used ( via the current testing unit they use, to test for other viral LRTI ) at primary care centres ( data says the 2nd highest reason for hospital admissions ( unplanned) in England ) if its proven effective for these infections in COPD etc too. Early trial results were very promising.
All Excellent news, progressing trial onto another phase and justifying costs, logistics and its involvement of secondary care, must be seen as a huge positive IMO.
SNG001 was always meant for very early interventions, even without CV19. To me, theyve just progressed from where they had to start ie hospital, to where they want it to be.
If this is effective in preventing the escalation of this terrible virus into more serious complications..........wow.
This drug was added last to Recovery I think. The trial link below shows it started in April 3rd, but as its ongoing and double blind and Phase 3 , they cant have results even this fast one presumes ?? Unless, its a different trial ?? Not had time to read it fully yet !
hTTps://clinicaltrials.gov/ct2/show/record/NCT04320615
I think this is the nebuliser from the photos I have seen ?? Not sure though ??
https://www.philips.co.uk/healthcare/product/HC85167/i-neb-battery-powered-drug-delivery-system
I have no concerns either . Im heavily invested, having added again last week. Discussion is good, I like to know my investments as much as poss. and happy to be challenged on them.
IMO, you dont embark on the second tranche of trials ( home ) when the first tranche evidence is poor. Particularly as they dont have to do this, it was an "OR" in the trial protocol. I think the ACE 2 thing is a red herring.....and might be a benefit ( see last paper I posted ). All IMO !
IF........and who knows ??........the virus caused ACE 2 levels to fall, then adding IFN and causing an increase may be beneficial ?? Im looking at the effect of low ACE2 levels as respiratory / circulatory function are affected by this and ACE 1 .......amongst other things
IT seems that timing is crucial.....at least what stage of infection that body is in, and also the pre-existing condition. Article below is very new, but suggests that this " stage of infection" is critical ?? If I read it correctly, infection may lead to a reduction in ACE2, so any stimulation may just neutralise this effect ??
hTTps://www.ahajournals.org/doi/10.1161/JAHA.120.016509
briefly RW ! Im confident that this is something SNG will have come across .....theyve been at it many years. I was looking through this today though ( but mostly the trial info and RM interview).... needed some more research to steady the nerves !!
RW......added another ...
hTTps://www.livescience.com/coronavirus-immune-interferon-response.html
RW, if you're interested Ive posted some info below, it s abit technical but might be helpful to you ??
hTTps://www.sciencedirect.com/science/article/pii/S1471489206000579