Member Info for Moneymunch

Wait  till the RTO of Lamellar barnes4, they're going to have plenty of cash, and what market cap for a listed Lamellor with the most exciting and sort after cutting edge nebuliser inhaler technology for the treatment of lung disorders associated with Covid-19, combined with Motifs ilcraprim in patient trials...£50m ,£100m plus and several £100m if proved effective....Fill ya Boots...Grab 'em while you can for the potential Transformational returns of Transformational returns from this current tiny market cap. ;-)

Get ready for the next substantial move North..
Profit takers mopped UP...1p plus at close still on the cards imho...Gla On and Up!!! :-)

Dr Nik Hirani, Reader in Respiratory Medicine and Associate Medical Director in Lothian and Former chair of NICE Thoracic Interstitial Lung Disease guideline committee, said: "Lamellar has very convincing data demonstrating strong in-vivo efficacy for Lamellasome formulations in a model relevant to pneumonitis, lung injury and ARDS. I have been following the development of LAMELLASOME™ technology and its development as a respiratory therapeutic over the past few years, and I believe it has real potential to manage the inflammatory respiratory symptoms seen in patients infected with SARS-CoV2."

hTtps://www.ptcommunity.com/wire/lamellar-biomedical-launches-program-designed-prevent-severe-respiratory-effects-covid-19-using

6/6/19

"We continue to believe that iclaprim has the potential to be an important new treatment option for hospitalised patients with ABSSSI and potentially also in patients with hospital-acquired bacterial pneumonia, including ventilator-associated bacterial pneumonia. In addition, we are exploring the use of iclaprim in other disease areas, including orphan indications such as Staphylococcus aureus lung infections in patients with cystic fibrosis and in ophthalmology, as evidenced by recently announced collaborative agreements.

8/4/20

Lamellar Biomedical Launches Program Designed to Prevent the Severe Respiratory Effects of COVID-19, Using its Unique LAMELLASOME™ Technology

....................

A LAMELLASOME™ nebulised treatment used at the early stages of COVID-19, in hospital or the community, could reduce the damaging and often fatal inflammatory response known as Acute Respiratory Distress Syndrome (ARDS) seen in patients. This early intervention has the potential to inhibit fibroproliferative changes during ARDS, markedly reducing severity, mortality and lowering the significant burden placed on the healthcare system.

The time between onset of symptoms of SARS-CoV2 infection and progression to more severe clinical manifestations of COVID-19 such as viral pneumonia and ARDS, is thought to be between 5 – 8 days. Inhaled LAMELLASOME™ treatment administered during this period has the potential to halt or reduce the severity of the disease progression of COVID-19 patients to requiring scarce critical care resource.

Lamellar has strong pre-clinical evidence of inhaled LAMELLASOME™'s protective nature. In a large animal in-vivo model of radiation-induced lung injury, designed to replicate the pathology found in the injured lung, which is representative of COVID-19 patient pathology, inhaled LAMELLASOME™ treatment protected lung cells and tissues from injury, pneumonitis and fibroproliferation/fibrosis at the alveolar/capillary membrane.

Dr Duncan Moore, Chairman of Lamellar, said: "In the past few weeks we have seen the terrible consequences COVID-19 can have on the respiratory function, particularly on vulnerable patient populations. We believe that that the inherent attributes of LAMELLASOME™ are extremely well suited to be a potential approach to preventing the onset of the serious respiratory symptoms seen in COVID-19 patients. Lamellar is focused on treating complex lung disorders and we believe that our Lamellasome formulations could make an important difference to patients and healthcare providers globally."

Join  UP the dots!!! Gla ;-)

Lamellar's Director appointed to the BoD of Motif, confirmed today....RTO into Lamellar looks like a dead cert imho....and Iclaprim, already cleared Phase 11 patient trials, and held up by the FDA at end of Phase 111 patient trials because of toxicity concerns from the intravenously administered drug, they wanted another Phase 111 trial that Motif couldn't afford, and now looks like Lamellar's nebulised inhaler technology's lead compound for the treatment of lung damage in Covid-19 patients could be Iclaprim, which can go straight into patient trials, cutting costs and time and saving Lamellar £10's of millions in its development. Gla holders Fill Ya Boots!!!:-)

1/5/19

Motif Bio Signs Agreement with Lamellar Biomedical

Evaluation of Iclaprim in Combination with LMS-611 for Cystic Fibrosis Lung Infections

Motif Bio plc (AIM/Nasdaq: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announced that the Company has signed an agreement with Lamellar Biomedical Limited (Lamellar) under which Motif Bio will conduct an in vivo pre-clinical study evaluating iclaprim in combination with Lamellar's patented LAMELLASOME(TM) technology.

Iclaprim has been granted U.S. orphan drug designation for Staphylococcus aureus pneumonia in patients with Cystic Fibrosis (CF). Lamellar's LAMELLASOME(TM) candidate LMS-611, which has mucokinetic (mucus clearing) properties, has demonstrated antibiotic potentiation (the enhancement of certain properties of antibiotics) and has European orphan drug designation for CF.

The companies believe that, based on pre-clinical data with the two individual components, the combination could be a promising potential treatment for lung infections in patients with CF.

Dr. Graham Lumsden, Chief Executive Officer of Motif Bio, said: "We have been looking for a way to optimise the development of iclaprim in patients with CF. We are excited about the preliminary data we have seen with Lamellar's technology and look forward to evaluating it in combination with iclaprim."

Dr. Alex McLean, Chief Executive Officer of Lamellar Biomedical, said: "CF is a key area of interest for Lamellar. We are delighted to announce this partnership with Motif Bio, which will evaluate the antibiotic potentiation properties of our LAMELLASOME(TM) technology in combination with iclaprim. This collaboration augments our own work in this orphan indication, which is focused on a novel nucleic acid-based therapeutic, as we strive to develop a range of highly effective treatment options for patients with CF."

 Lammeller RTO, is the quickest and cheapest route to bring their technology to market, and it also looks like they have a vested interest in Motifs lead drug compound. This looks like a dead cert and no brainer following today's Rns confirming Lamellar's Director to the BOD of Motif....Fill ya boots for life changing returns...imho...Gl :-)

Many multiples  in due course, current market cap on today's rise £2m...ho ho ho ...can you imagine the Upside on Lamellar RTO, and Iclaprim confirmed as lead compound for their Nebuliser inhaler technology for the treatment of Covid lung disorders, with patient trials underway...Boooooooom!!! :-)

Perfectly poised for positive news...confirmation of the new CEO and an Update on SFX-01, very possibly for Covid treatment trials. Gla :-)

Dr Nik Hirani, Reader in Respiratory Medicine and Associate Medical Director in Lothian and Former chair of NICE Thoracic Interstitial Lung Disease guideline committee, said: "Lamellar has very convincing data demonstrating strong in-vivo efficacy for Lamellasome formulations in a model relevant to pneumonitis, lung injury and ARDS. I have been following the development of LAMELLASOME™ technology and its development as a respiratory therapeutic over the past few years, and I believe it has real potential to manage the inflammatory respiratory symptoms seen in patients infected with SARS-CoV2."

hTtps://www.ptcommunity.com/wire/lamellar-biomedical-launches-program-designed-prevent-severe-respiratory-effects-covid-19-using

6/6/19

"We continue to believe that iclaprim has the potential to be an important new treatment option for hospitalised patients with ABSSSI and potentially also in patients with hospital-acquired bacterial pneumonia, including ventilator-associated bacterial pneumonia. In addition, we are exploring the use of iclaprim in other disease areas, including orphan indications such as Staphylococcus aureus lung infections in patients with cystic fibrosis and in ophthalmology, as evidenced by recently announced collaborative agreements.

8/4/20

Lamellar Biomedical Launches Program Designed to Prevent the Severe Respiratory Effects of COVID-19, Using its Unique LAMELLASOME™ Technology

....................

A LAMELLASOME™ nebulised treatment used at the early stages of COVID-19, in hospital or the community, could reduce the damaging and often fatal inflammatory response known as Acute Respiratory Distress Syndrome (ARDS) seen in patients. This early intervention has the potential to inhibit fibroproliferative changes during ARDS, markedly reducing severity, mortality and lowering the significant burden placed on the healthcare system.

The time between onset of symptoms of SARS-CoV2 infection and progression to more severe clinical manifestations of COVID-19 such as viral pneumonia and ARDS, is thought to be between 5 – 8 days. Inhaled LAMELLASOME™ treatment administered during this period has the potential to halt or reduce the severity of the disease progression of COVID-19 patients to requiring scarce critical care resource.

Lamellar has strong pre-clinical evidence of inhaled LAMELLASOME™'s protective nature. In a large animal in-vivo model of radiation-induced lung injury, designed to replicate the pathology found in the injured lung, which is representative of COVID-19 patient pathology, inhaled LAMELLASOME™ treatment protected lung cells and tissues from injury, pneumonitis and fibroproliferation/fibrosis at the alveolar/capillary membrane.

Dr Duncan Moore, Chairman of Lamellar, said: "In the past few weeks we have seen the terrible consequences COVID-19 can have on the respiratory function, particularly on vulnerable patient populations. We believe that that the inherent attributes of LAMELLASOME™ are extremely well suited to be a potential approach to preventing the onset of the serious respiratory symptoms seen in COVID-19 patients. Lamellar is focused on treating complex lung disorders and we believe that our Lamellasome formulations could make an important difference to patients and healthcare providers globally."

 0

Lamellar's Director appointed to the BoD of Motif, confirmed today....RTO into Lamellar looks like a dead cert imho....and Iclaprim, already cleared Phase 11 patient trials, and held up by the FDA at end of Phase 111 patient trials because of toxicity concerns from the intravenously administered drug, they wanted another Phase 111 trial that Motif couldn't afford, and now looks like Lamellar's nebulised inhaler technology's lead compound for the treatment of lung damage in Covid-19 patients could be Iclaprim, which can go straight into patient trials, cutting costs and time and saving Lamellar £10's of millions in its development. Gla holders Fill Ya Boots!!!:-)

1/5/19

Motif Bio Signs Agreement with Lamellar Biomedical

Evaluation of Iclaprim in Combination with LMS-611 for Cystic Fibrosis Lung Infections

Motif Bio plc (AIM/Nasdaq: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announced that the Company has signed an agreement with Lamellar Biomedical Limited (Lamellar) under which Motif Bio will conduct an in vivo pre-clinical study evaluating iclaprim in combination with Lamellar's patented LAMELLASOME(TM) technology.

Iclaprim has been granted U.S. orphan drug designation for Staphylococcus aureus pneumonia in patients with Cystic Fibrosis (CF). Lamellar's LAMELLASOME(TM) candidate LMS-611, which has mucokinetic (mucus clearing) properties, has demonstrated antibiotic potentiation (the enhancement of certain properties of antibiotics) and has European orphan drug designation for CF.

The companies believe that, based on pre-clinical data with the two individual components, the combination could be a promising potential treatment for lung infections in patients with CF.

Dr. Graham Lumsden, Chief Executive Officer of Motif Bio, said: "We have been looking for a way to optimise the development of iclaprim in patients with CF. We are excited about the preliminary data we have seen with Lamellar's technology and look forward to evaluating it in combination with iclaprim."

Dr. Alex McLean, Chief Executive Officer of Lamellar Biomedical, said: "CF is a key area of interest for Lamellar. We are delighted to announce this partnership with Motif Bio, which will evaluate the antibiotic potentiation properties of our LAMELLASOME(TM) technology in combination with iclaprim. This collaboration augments our own work in this orphan indication, which is focused on a novel nucleic acid-based therapeutic, as we strive to develop a range of highly effective treatment options for patients with CF."

Lol, don't talk wet hunkymunky, you appear some what clueless........iclaprim passed phase 11 trials, and the FDA didn't clear the drug in the all important phase 111 trials because of toxicity concerns, the drug was administered intavenously....the FDA wanted Motif to carryout another phase 111 trial to clear up any concerns, but Motif didn't didn't have the funds...iclaprim, is now clear to enter phase 111 trials by anyone who wants to advance development again, ad if it's Lamellar , then it would be administered through their nebulised/inhalor technology straight to the lungs which would very likely reduce any toxicity issus associated with liver function. Gla Holders.....On and very much UP!!! ;-)

Looks like a dead cert with Lamellar's Chris Wardhaugh appointed as a Non-Executive Director of MTFB;

If Iclaprim is the main compound in Lamellar's LAMELLASOMEâ„¢ nebulised formulation treatment believed to have inherent attributes that are extremely well suited to be a potential approach to preventing the onset of the serious respiratory symptoms seen in COVID-19 patients, then presumably because Iclaprim has already been cleared in Phase 11 patient trials, then Lamellar's technology and formulation could go straight into CV patient trials. This would be highly significant and make Lamellar the most likely RTO target and transformational for all invested, with the prospect of Lamellar's inhaler technology reaching CV patients immediately , and then potentially scaled up for commercialisation on positive trials, and if this is the case then this would be absolutely huge and maybe the multi-bags of all multi-bags from current rockbottom sp... Gla !!! ;-)

Looking good and strong!!! Gla holders On and UP!!! ;-)

Looks like a dead cert with Lamellar's Chris Wardhaugh appointed as a Non-Executive Director of MTFB;

If Iclaprim is the main compound in Lamellar's LAMELLASOMEâ„¢ nebulised formulation treatment believed to have inherent attributes that are extremely well suited to be a potential approach to preventing the onset of the serious respiratory symptoms seen in COVID-19 patients, then presumably because Iclaprim has already been cleared in Phase 11 patient trials, then Lamellar's technology and formulation could go straight into CV patient trials. This would be highly significant and make Lamellar the most likely RTO target and transformational for all invested, with the prospect of Lamellar's inhaler technology reaching CV patients immediately , and then potentially scaled up for commercialisation on positive trials, and if this is the case then this would be absolutely huge and maybe the multi-bags of all multi-bags from current rockbottom sp... Gla !!! ;-)

8/4/20

Lamellar Biomedical Launches Program Designed to Prevent the Severe Respiratory Effects of COVID-19, Using its Unique LAMELLASOME™ Technology

....................

A LAMELLASOME™ nebulised treatment used at the early stages of COVID-19, in hospital or the community, could reduce the damaging and often fatal inflammatory response known as Acute Respiratory Distress Syndrome (ARDS) seen in patients. This early intervention has the potential to inhibit fibroproliferative changes during ARDS, markedly reducing severity, mortality and lowering the significant burden placed on the healthcare system.

The time between onset of symptoms of SARS-CoV2 infection and progression to more severe clinical manifestations of COVID-19 such as viral pneumonia and ARDS, is thought to be between 5 – 8 days. Inhaled LAMELLASOME™ treatment administered during this period has the potential to halt or reduce the severity of the disease progression of COVID-19 patients to requiring scarce critical care resource.

Lamellar has strong pre-clinical evidence of inhaled LAMELLASOME™'s protective nature. In a large animal in-vivo model of radiation-induced lung injury, designed to replicate the pathology found in the injured lung, which is representative of COVID-19 patient pathology, inhaled LAMELLASOME™ treatment protected lung cells and tissues from injury, pneumonitis and fibroproliferation/fibrosis at the alveolar/capillary membrane.

Dr Duncan Moore, Chairman of Lamellar, said: "In the past few weeks we have seen the terrible consequences COVID-19 can have on the respiratory function, particularly on vulnerable patient populations. We believe that that the inherent attributes of LAMELLASOME™ are extremely well suited to be a potential approach to preventing the onset of the serious respiratory symptoms seen in COVID-19 patients. Lamellar is focused on treating complex lung disorders and we believe that our Lamellasome formulations could make an important difference to patients and healthcare providers globally."

Dr Nik Hirani, Reader in Respiratory Medicine and Associate Medical Director in Lothian and Former chair of NICE Thoracic Interstitial Lung Disease guideline committee, said: "Lamellar has very convincing data demonstrating strong in-vivo efficacy for Lamellasome formulations in a model relevant to pneumonitis, lung injury and ARDS. I have been following the development of LAMELLASOME™ technology and its development as a respiratory therapeutic over the past few years, and I believe it has real potential to manage the inflammatory respiratory symptoms seen in patients infected with SARS-CoV2."

https://www.ptcommunity.com/wire/lamellar-biomedical-launches-program-designed-prevent-severe-respiratory-effects-covid-19-using

1/5/19

Motif Bio Signs Agreement with Lamellar Biomedical

Evaluation of Iclaprim in Combination with LMS-611 for Cystic Fibrosis Lung Infections

Motif Bio plc (AIM/Nasdaq: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announced that the Company has signed an agreement with Lamellar Biomedical Limited (Lamellar) under which Motif Bio will conduct an in vivo pre-clinical study evaluating iclaprim in combination with Lamellar's patented LAMELLASOME(TM) technology.

Iclaprim has been granted U.S. orphan drug designation for Staphylococcus aureus pneumonia in patients with Cystic Fibrosis (CF). Lamellar's LAMELLASOME(TM) candidate LMS-611, which has mucokinetic (mucus clearing) properties, has demonstrated antibiotic potentiation (the enhancement of certain properties of antibiotics) and has European orphan drug designation for CF.

The companies believe that, based on pre-clinical data with the two individual components, the combination could be a promising potential treatment for lung infections in patients with CF.

Dr. Graham Lumsden, Chief Executive Officer of Motif Bio, said: "We have been looking for a way to optimise the development of iclaprim in patients with CF. We are excited about the preliminary data we have seen with Lamellar's technology and look forward to evaluating it in combination with iclaprim."

Dr. Alex McLean, Chief Executive Officer of Lamellar Biomedical, said: "CF is a key area of interest for Lamellar. We are delighted to announce this partnership with Motif Bio, which will evaluate the antibiotic potentiation properties of our LAMELLASOME(TM) technology in combination with iclaprim. This collaboration augments our own work in this orphan indication, which is focused on a novel nucleic acid-based therapeutic, as we strive to develop a range of highly effective treatment options for patients with CF."

24/10/19

RNS Number: 9200Q Motif Bio PLC, 24 October 2019

Motif Bio plc (AIM/Nasdaq: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announced that the Company has signed an agreement with the Walter Reed Army Institute of Research (WRAIR) to conduct pre-clinical testing to evaluate novel combinations with iclaprim to improve safety and efficacy administered by a novel enhanced aerosol technology.

htTps://adisinsight.springer.com/drugs/800018080

6/6/19

"We continue to believe that iclaprim has the potential to be an important new treatment option for hospitalised patients with ABSSSI and potentially also in patients with hospital-acquired bacterial pneumonia, including ventilator-associated bacterial pneumonia. In addition, we are exploring the use of iclaprim in other disease areas, including orphan indications such as Staphylococcus aureus lung infections in patients with cystic fibrosis and in ophthalmology, as evidenced by recently announced collaborative agreements.

The Company's Directors remain focused on sourcing an appropriate reverse takeover candidate for Motif Bio. The Company is required to make an acquisition which constitutes a reverse takeover under the AIM Rules by 28 July 2020, failing which the Company's ordinary shares would be suspended from trading on AIM pursuant to AIM Rule 40. The Company's admission to trading on AIM would then be cancelled six months from the date of suspension, should the reason for the suspension not have been rectified. At present, no assurances can be given that the efforts to source and/or complete a reverse takeover transaction will be successful.

The following information is disclosed pursuant to Rule 17 and Schedule Two Paragraph (g) of the AIM Rules for Companies:

Christopher Thomas Wardhaugh, aged 50, holds or has held the following directorships or partnerships in the past five years:

Current Directorships or Partnerships

Previous Directorships or Partnerships

Altair Medical

Clyde Biosciences

Lamellar Biomedical

Sercader Limited

Chris currently holds no interest in the ordinary share capital, or other securities, of Motif Bio.

Here's confirmation of the Lamellar connection. Gla ;-)

RNS Number : 7166L
Motif Bio PLC
04 May 2020

Directorate Changes & Corporate Update

Motif Bio plc (AIM: MTFB), which has been reclassified as an AIM Rule 15 cash shell, announces the following changes to the Board, with immediate effect:

- Chris Wardhaugh is appointed as a Non-Executive Director;

- Jonathan Gold, the Company's current Chief Financial Officer ('CFO'), has been appointed as President and Chief Business Officer;

- Graham Lumsden, the Company's Chief Executive Officer ('CEO'), will step down from his role as CEO and become a Non-Executive Director; and

- Bruce Williams continues in his role as Chairman.

Christopher (Chris) Wardhaugh

Chris is currently a Non-Executive Director of Altair Medical Limited and Lamellar Biomedical Limited, both based in Scotland. Chris is also Chief Business Officer of MGB Biopharma Limited, a clinical-stage antibiotic company and is the founder of Sercader Limited, a life sciences advisory firm.

Chris has over 28 years' experience in life sciences with international experience across large and small companies, all stages of development and commercialisation of companies including preclinical and clinical development, product launches throughout Europe and the United States, M&A and corporate development. Chris has an impressive transaction history working on deals including product licensing, IPOs and both Angel and VC investments.

Commenting, Bruce Williams, Chairman of Motif Bio, said: "We welcome Chris to the Board as we focus on sourcing an appropriate reverse takeover candidate for Motif Bio. We believe that the Company will benefit from Chris's breadth of knowledge and transactional experience and we will provide shareholders with further updates in due course."

Jonathan Gold

Jonathan Gold is appointed President and Chief Business Officer, an expanded role that includes his previous responsibilities as CFO.

Graham Lumsden

Graham has stepped down from his role as CEO, a role he has had since the Company's IPO in 2015. Graham will continue to support the Company as a Non-Executive Director.

Current Financial Position

The Directors of Motif Bio have continued to impose disciplined cost controls, with the Company maintaining very limited operations. As a result, Motif Bio's cash balance is approximately £0.23 million as at 4 May 2020, which has allowed the Company's cash runway to be extended into June.

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Tiziana Life Sciences #TILS Gabriele Cerrone, Founder & Chairman speaking with @ZaksTradersCafe
It has been a boom time in the #pharmaceutical sector

https://twitter.com/zakstraderscafe?lang=en

Outlook

look

Whilst the current economic uncertainty resulting from the COVID-19 pandemic and resultant restrictions mean that it is not possible to predict with accuracy what the impact will be on Fusion for the forthcoming financial period, the Board believes, for the reasons set out above, that the Company is well positioned to continue to trade with limited impact on its service provision. Further, it provides an opportunity for the Company to try to contribute to a solution to the COVID-19 pandemic by supporting its clients and completing a proof-of-concept on the Library using antibodies that may be able to address the COVID-19 disease.

Paul Kerr, CEO of Fusion Antibodies plc commented : "We are delighted to be able to announce this oversubscribed placing which will help us in our critical work. In these currently extremely challenging times, we now have the resources to undertake the additional proof-of-concept work on the Mammalian Antibody Library Discovery Platform in respect of COVID-19, as well as for our existing oncology targets, whilst continuing to support our clients in their vital role. We remain confident that our products and services can help to accelerate finding a solution to this global health crisis."