Member Info for Mer400

Sorry stach

Stacy I think your trying to scare people away. Val in my opinion have never been in a better position. 401 finished 201 finished and awaiting results Japanese pharma testing 301. About 1.3 million in cash and 13p warrants to go in or get canceled. Yes we may need a fund raise next year but if 201 comes up trumps we won’t.

Weekends won’t count 5 days is 5 days

Hey value I think you need to read it again, I only get 1.5 million at most.

Of all the half year and yearly reports I’ve read from Val this has to be the best by far. Very clear and straight to the point and best of all I wasn’t thinking “placing in a few months then”. Fantastic.

Why would anyone buy to be in over the weekend what difference does it make? Your either in or out and news could land at any time. I’ve never understood why people say that.

Martc point noted I obviously don't agree as I believe people should earn what they would earn elsewhere.

I think someone mentioned the other day regarding the new emphasis on women's health, this could be due to 20 also being adaptable for ovarian and breast cancer. Prostate was chosen for the trial as its and unmet clinical need and the path to commercialisation can be fast tracked by the FDA, if the results are good enough we should pick up a partner relatively quickly and on to market not long after.

Stumbler why don't you donate your salary to help out

No One in their right mind would exercise warrants now, why expose yourself to risk for absolutely no reason. wait until news comes if is good buy your shares at 13p and sell them for a profit if news is bad don't bother.

You might find that the warrant holders are selling their shares to keep the price down so they don't have to over expose.

Warrants can be exercised whenever you want as standard, the company got the addition put in that they could force them to exercise if they stay above 15p for 5 days.

Apparently the technology was never used so nothing is owed.

The patent term extension is based on the time the product is in clinical testing and regulatory review. A patent term may be extended for a period of time that is the sum of one-half of the time in the testing phase, plus all the time in the review phase.3 However, the extension period is reduced if any of this period occurred prior to the patent's issuance or if the applicant is found not to have acted with due diligence during clinical testing and regulatory review. The patent term extension cannot exceed five years. The total patent term including the extension cannot exceed 14 years following regulatory approval.

Borgie do you have another source?

I think 5 years to get through stage 3 could easily be shortened on good data, if they're are no side effects which there aren't and the drug is better (yet to be shown) than the best treatment on the market they good get to market much quicker as Prostate is and unmet clinical need.

Sambar, traditional patents have 20 years, these kind of patents are granted more time as it's recognised that they take an age to bring to market due to clinical trials. It's not just 201 that has a long development period they all have to jump through the same hoops.

what's the relationship with VAL

As far as I'm aware that's all they can do, pain killers which don't really work, they just have to put up with it. One of the main problem with it is infertility. This is why Japan will be super interested as their population is set to shrink.

Not at all, there must be something there. 2 seriously unmet clinical needs, Prostate and Endometriosis

I think this was human error, where a far higher dose was given to a patient and the trial was stopped while it was investigated. This was all just rumour tho as you say nothing was ever reported.

It's all water under the bridge now, they seem to have found MTD at 8 mgkg .

Based on the 4 mg dosing this would be expelled in a day or so leaving 6 days until next dosage, if this low dose can half the PSA levels imagine what daily dosing at 8mg will do.

I think the trial extensions were more to do with recruitment, they need enough data from the trial to proceed to the next stage, George explains how very difficult it is to recruit. It must be very frustrating not being able to continue as you are trying to recruit patients.

The purpose of this trial was to show safety so they didn't't and probably wouldn't get permission to dose at those levels at this stage.

With safety data in hand they should get permission to dose daily in the next trial.