RE: Type I, II, and III interferon signatures correspond to COVID-19 disease severity13 Mar 2021 07:54
Spin,
Evidence has been growing as to why INF B might work later in disease.
A paper last week highlighted that high levels of the protein GM-CFS being highly correlated to covid deaths. Control of this protein is important in MS patients and INF B is used in MS for this reason.
I have linked together the science below on reddit chat a week or so back when Phil G found the papers......
The GM-CSF link could explain why the hospital data was better than the SNG team expected. Some thoughts below.
There are a large number of papers that have shown diminshed numbers and exhaustion of T cells in severe covid patients.
Interferon-beta treated MS patients produce increased specific T cells that are associated with the development of neutralizing antibodies which is why the treatment works. These neutralising antibodies are also essential in fighting viral infections.
You then also have the STAT-5 link above where INF beta turns off this signalling in T cells hence suppressing GM-CSF.
So to summarise INF beta = increased T cell production = neutralising antibodies = better at fighting covid with the advantage of turning off STAT-5 and suppressing GM-CFS.
Also a paper from early March show that use of INF B combined with corristeriods like dexamethasone resulted in better clinical outcomes.
So we have scientific literature showing why INF B given early can be good and also emerging evidence about why our P2 results given later were good.
I can link all the papers if you want to review them.
The cellular science is very solid we just now need further clinical proof.
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