RE: “If it wasn’t activating, would tolerability be an issue?”23 Nov 2022 20:10
“This very positive progress reflects the safety profile and tolerability demonstrated in patients enrolled in the study to date." Alastair Smith RNS 1st September, 2022
Definition: Drug tolerability refers to the degree to which drugs' overt adverse effects can be tolerated by patients. The tolerability profile is of comparative importance to its efficacy and safety, as it largely determines adherence to treatment and ultimately treatment success or failure.
“Statements about clinical trial data should include proper qualifications so that investors can make their own informed investment decision about the significance (or lack thereof) of the applicable data. Particular attention should be paid to disclosure around a product’s safety or efficacy as these disclosures draw particular attention from SEC and DOJ, and can potentially draw ire from the FDA if they inaccurately reflect the scientific data.”