Ben Richardson, CEO at SulNOx, confident they can cost-effectively decarbonise commercial shipping. Watch the video here.
Heard back from Davey Smith the Protocol Co Chair for Activ 2. He said the other agents are starting today and tomorrow.
This means SNG001 had a clear week on its own which is great news. They should have made brilliant progress in that time...
https://twitter.com/DaveySmithMD
Hi Mike. The other agents are starting now, depending on the site and randomization. Camostat is rolled their first participant today.
With 50% of my ISA and SIPP definitely balls deep, my wife is fully balls deep as since I generously topped up her share ISA she's all in on Avacta.
She was very excited when I showed her a screen grab of her Share ISA account this morning. Still not touching this for a long time. A long way to go...
Good to see this focus, Francis Collins is actually Fauci's boss at the NIH but has taken a back seat on Covid19 as Fauci has more experience with infectious diseases. Collins is also very very close to the CEOs of some of the major US pharma's and they'll be paying very close attention to the outcome of our ACTIV2 trial.....
Just for clarification, Activ2 has a safety & data monitoring committee. My understanding is they don't have to wait for 28 days, they have ongoing access to data as per the published Activ2 masking protocol. Synairgen get access on day 28
Masking Description:
Unblinded data will be provided to the Data and Safety Monitoring Board for interim analyses. Unblinded Day 28 data will also be provided to a small group of people from the company who owns the investigational agent, to assist the company in deciding if the agent should move into phase 3 evaluation; or in choosing a dose of their agent to move into phase 3 evaluation.
Just a thought but would the fact PII data was so good mean the trial teams will better motivated this time around to push the PIII that bit harder compared to other trials because they'll be aware they could really be helping people?
Pll shouldn't take too long, according to the clinical trials site there are 95 recruitment centres in Activ2!!!
https://clinicaltrials.gov/ct2/show/NCT04518410#contacts
Gave Jeff Craven who maintains the tracker a nudge via Twitter during the week and he's now added SNG001 to the tracker
https://www.raps.org/news-and-articles/news-articles/2020/3/covid-19-therapeutics-tracker
The Regulatory Affairs Professionals Society (RAPS) is the largest global organization of and for those involved with the regulation of healthcare and related products, including medical devices, pharmaceuticals, biologics and nutritional products. Founded in 1976, RAPS helped establish the regulatory profession and continues to actively support the professional and lead the profession as a neutral, non-lobbying nonprofit organization
Thanks 28 days is this Wednesday 17th Feb, with Activ2 now started Synairgen will have 2 ongoing sets of data to share with the FDA and other regulatory authorities with a view to gaining EMA
The next few weeks will be very exciting...
As mentioned, I'd rather engage with a Journalist than send a complaint and consequently, I've had a response from Katherine. I've since responded and explained that I still feel the piece was misleading. That not distinguishing between injected and inhaled is the primary cause of that misinformation. IMHO, she's defended her position badly and I've sent her some more links/info on SNG001 and asked her to do some more homework on the inhaled treatment so she has better information to hand for the future.
Thanks for getting in touch. I was referring to results from the Solidarity trial which found it didn’t work. But I said in my script that treatments might work at different stages in the disease and studies are ongoing - referring to interferon beta and convalescent plasma. In a short TV item we can’t cover the hundreds of drugs and trials that are underway around the world. This was a summary of some of them. You may not be aware that my colleague Justin Rowlatt recently covered the start of phase 3 interferon beta trials for TV and online. I hope that helps? Many thanks
Katharine
I've messaged Katharine Da Costa, the BBC video journalist who produced the BBC News piece via Twitter. I agree the piece is misleading but think educating journalists who are unintentionally misleading people might have better results than complaining....
Just tweeted
We’re excited to welcome @POTUS today to #NIH for a tour of @NIAIDNews ’s Vaccine Research Center and a briefing on the latest NIH #COVID19 research. Tune in to see his remarks LIVE at 4:30 p.m. ET here on Twitter. https://twitter.com/NIH/status/1359869193173282818
Worth tuning in, with the positive Kansas video update re Activ2 perhaps the #SNG001 trial will finally get announced formally by NIH and promising treatments discussed by Biden
This is the link https://www.facebook.com/watch/live/?v=225051529263564&ref=watch_permalink
Great find, one day in the not too distant future, someone from the FDA, NIH or perhaps Fauci will say, we've been testing this great inhaled antiviral treatment called SNG001 from Synairgen with some great results. We can use it very early on at home but also in the hospital. It's do flexible and easy to administer. It will be like pushing a snowball down a mountain. Things are starting to really come together. Congrats to all the LTH for staying with SNG. Keep up all the great research. Hopefully, the message will finally get through to the UK press and some harder questions will be asked of our Government and of those responsible for large Covid trials in the UK.
I think it's worth thanking him for the response but reminding him that despite some very promising Pll results the treatment wasn't even mentioned during a recent Science Tech/Health committee meeting when other treatments which have failed were. It's not a dig but more with these favourable results and the fact we now have multiple trials ongoing plus significant support from the US Government with Activ 2, it's a surprise that a promising treatment like this wasn't mentioned...
Perhaps you could even leave out the Activ2 bit and then when the NIH formally announce send a second follow up pointing this out.
One thing to consider is objective, what is the objective of speaking to our MP's?
For me it would be to ensure the current trials get as much support from the Govt as possible. This is a very promising treatment, it needs good support to get the Plll trial finished ASAP so it gives the relevant authorities a chance to review results sooner rather than later and if positive issue an emergency use approval so we can start being proactive in saving some lives, reduce pressure on the NHS and help the country get back to normal.