RE: RNS9 Jul 2025 07:01
ANGLE’s technology offers pharma companies a powerful tool to make drug development more cost-effective, efficient, and targeted, ultimately improving the likelihood of successful, personalised cancer treatments.
Cost Advantages
Reduced Trial Costs: ANGLE’s Parsortix system enables liquid biopsy (blood-based) analysis of circulating tumour cells (CTCs), which allows for repeat, minimally invasive sampling. This approach reduces the need for costly and invasive tissue biopsies, lowering overall trial expenses.
Efficient Patient Selection: The technology improves the identification of patients most likely to benefit from targeted therapies, enabling more precise recruitment for clinical trials. This can result in smaller, more efficient studies, saving millions in drug development costs.
Outsourced Services: Pharma companies can leverage ANGLE’s GCP-compliant laboratory services for CTC harvesting and analysis, eliminating the need for capital investment in equipment and operator training, further reducing operational costs.
Effectiveness of Treatment
Personalised Medicine: Parsortix allows for real-time monitoring of cancer progression and response to therapy by capturing live, intact CTCs and clusters. This supports the development of personalised, adaptive treatment regimens, leading to better patient outcomes.
Improved Drug Targeting: By facilitating the selection of patients with specific metastatic profiles (e.g., highly metastatic CTC clusters), pharma companies can focus novel treatments on those most likely to benefit, increasing the effectiveness of new drugs.
Companion Diagnostics: ANGLE’s technology is being integrated as a companion diagnostic in partnership with major pharma companies (e.g., AstraZeneca, Eisai), enabling drugs to be matched with patients based on real-time biomarker status, which enhances treatment precision and reduces unnecessary exposure to ineffective therapies.
Continuous Monitoring: The system supports longitudinal monitoring before, during, and after treatment, providing actionable data on drug effectiveness and cancer evolution over time, which is not possible with standard tissue biopsies.
Strategic and Regulatory Advantages
FDA Clearance: ANGLE’s Parsortix system is the only FDA-cleared product for harvesting CTCs for downstream analysis, providing a regulatory edge and building confidence in its use for clinical and drug development applications.
Scalable Partnerships: By focusing on large pharma service contracts, ANGLE enables pharma partners to fund assay development, clinical trials, and market launch, reducing the financial burden and risk for both parties.