RE: Trinity Delta initiate on OBD with BUY and 52p PT19 Oct 2024 09:33
Again, the commercial opportunity and our view of the expected market positioning for EpiSwitch PSE is addressed later in this note.
Development pipeline: two near-term prospects
There are six test programmes within the development pipeline (Exhibit 6). Two of these, EpiSwitch NST, for colorectal cancers, and EpiSwitch SCB, for the most common canine cancers, are ready for partnering or out-licensing with appropriate specialised players. Earlier programmes include both a diagnostic and a prognostic test for Amyotrophic Lateral Sclerosis (ALS), also known more generally as Motor Neurone Disease (MND), that was evaluated alongside Mitsubishi Tanabe Pharma America’s Radicava (edaravone) study programmes.
Earlier still are three programmes: rheumatoid arthritis, looking at predicting likely methotrexate responders and flaring/residual disease monitoring; metabolic dysfunction-associated steatohepatitis (MASH, formerly known as NASH), looking at early detection using a simple blood test screen; and breast cancer, a screening test for earlier detection of disease across multiple groups. Broader potential applications of the EpiSwitch platform include the incorporation of existing (eg EpiSwith CiRT) or future diagnostic tests by drug developers as part of their clinical development programmes with the aim of developing companion diagnostic tests, or leveraging OBD’s proprietary biomarker data with artificial intelligence/machine learning (AI/ML) approaches to identify actionable insights. OBD is already active in the former area and will shortly start running CiRT tests on blood samples from endometrial cancer patients enrolled in a clinical trial of an undisclosed immune checkpoint inhibitor as part of an agreement with a top ten pharma company