RE: MIDD Development14 Oct 2025 18:32
By Mark Davies and Hayley Close at PhysiomicsThe pharmaceutical industry is under increasing pressurefrom healthcare providers and regulatory agencies alike todevelop novel effective therapeutics quicker and at lower cost.The use of computational approaches across drug discoveryand development (DD&D) offers the opportunity for addressingthese challenges, with established areas such as modellingand simulation, often referred to as model-informed drugdevelopment (MIDD), entering a golden age.Mathematical modelling and simulation to supportdrug developmentThe feld of MIDD refers to the strategic design and integrationof mathematical models into DD&D workfows to facilitatedecision-making, from target ID and candidate design/selection,to preclinical and clinical research, including insights for doseselection and optimisation.Many of the models that make up MIDD are based onpharmacokinetic-pharmacodynamic (PK/PD) modelling, amathematical approach to studying the relationship betweenthe two components, connecting drug dose to physiologicalresponse.1This breaks down as what the body does to thedrug (ie, pharmacokinetics) and what the drug does to thebody (ie, pharmacodynamics), including elements of toxicity andadverse effects.Building on these techniques, population pharmacokinetic(PopPK) models are designed to study the pharmacokinetics at