Member Info for Laura2022

Blue skies, blue horses* and great science greeted us in Denver, Colarado for this year’s American Conference on Pharmacometrics (ACoP) conference – a key annual event for the MIDD and pharmacometrics community.

The event offered plenty of opportunities to hear about recent developments in the field. A few key highlights included:

👉 Emerging solutions using AI to support PKPD/PMx workflows, particularly in extracting knowledge from published manuscripts, with James Zou’s keynote introducing the concept of a ‘Virtual Lab’.

👉 A deep dive into Quantitative Systems Pharmacology (QSP) applications, from 12 years of QSP support in ADC oncology development. Along with excellent QSP case examples beyond oncology such as virology, rheumatoid arthritis and neurodegenerative disorders.

👉 Novel statistical approaches are helping turn RWD and digital health data from wearables (which can often be noisy) into powerful insights on treatment effects.

👉 Adaption of MIDD approaches for new drug modalities (e.g. for differences in drug elimination pathways) such as siRNA, ASO, peptides, protein degraders or CAR-T therapies.

👉 Increasing guidance and clarity around regulatory best practice in MIDD, with a focus on defining a model’s ‘context of use’ (COU) and using the Model Master File (MMF) to improve transparency and interdisciplinary communication.

At Physiomics plc we are exploring how #MIDD and #QSP modelling offers a translational bridge in this space – connecting drug dose, biomarker response and clinical outcomes.

🛫 Next up, our team will be at #BIOEurope in November, and you can also catch us at #PKUK in November – looking forward to continuing the conversation there!

Who buys just 1 share!!!

Uk energy self sufficiency is a must

The Malawi news on MKA may help REE

Tuan

So , what's your course of action going to be ? Apart from whining

They have 6-9mth runway till end Q22026 at least

They have won 3 orders in last 2mths

I can see Philpps or medical imaging company making an offer

Mgmt won't get 75% backing for this "proposal '

Cash and cash equivalents of US$7.3m as at 30 June 2025 (

Rock123

Looks like POLX about to pop after being smashed down from 1p

Afternoon Rick123

Not in this, but going great guns !! Amazing

Rick123

Are u still in PYC ?

I'm currently up 100% on WHI and I believe there will be similar situation here wjere some major holders prevent this CEO led daylight robbery

Norfolk

Yes, its playing out quite nicely ")

Today and Friday all shown as sells

0.169p to 0.173p are all buys

Why else would be they offering 0.16p for millions of shares on an advertised bid of 0 15

Tuan

I get you're very underwater here, but clearly the large TR1 holders are so far holding their ground

Takeover or counter offer could lead to 50%+ in an instant

eg

just 2 trading days ago !!

loadof******

posted in: polx

posts: 183

price: 0.185

no opinion

re: 3.5mln buy23 oct 2025 18:50

have they deliberately crashed the price to let friends and family in cheap?

loadof******

posted in: polx

posts: 183

price: 0.185

no opinion

re: 3.5mln buy23 oct 2025 18:37

interesting, you’d be mad to drop that much in here unless you’ve been tipped off.

loadof******

posted in: polx

posts: 183

price: 0.185

no opinion

re: why is polx down over 99% this year?23 oct 2025 18:27

interesting 3.5m buy just before the close, wonder if they know something?

Make your mind up

Every day you change your tune !!

Filtered

Only about £8k-10k lett which.. again...suggests that no big overhang

Ready POLX moves 50%+ from here

Can sell 35mln at 0 252p!

Now 0.73p as juat added £1000 at that price

A small amount available so added more at 25