MRx4DP0004 to Treat COVID-199 May 2020 01:08
First sets of results from commencement of study will be at the 2 week point, these results will be from the following 8 assessments:
Number of patients with at least 95% oxygen saturation on room air in each treatment arm [ Time Frame: Day 1 to Day 14 ]
Oxygen saturation will be measured as per local standard procedures
Time to patients with at least 95% oxygen saturation on room air in each treatment arm [ Time Frame: Day 1 to Day 14 ]
Oxygen saturation will be recorded daily during hospitalisation to determine the mean time for each arm to reach at least 95% saturation
Number of patients with an improvement in the National Early Warning Score (NEWS) 2 in each treatment arm [ Time Frame: Day 1 to Day 14 ]
The NEWS 2 is based on aggregate scoring of physiological measurements including respiration rate, oxygen saturation, systolic blood pressure, pulse rate, level of consciousness and temperature
Number of patients with an deterioration in the National Early Warning Score (NEWS) 2 in each treatment arm [ Time Frame: Day 1 to Day 14 ]
The NEWS 2 is based on aggregate scoring of physiological measurements including respiration rate, oxygen saturation, systolic blood pressure, pulse rate, level of consciousness and temperature
Number of patients requiring Continuous Positive Airway Pressure in each treatment arm [ Time Frame: Day 1 to Day 14 ]
Details of required respiratory support will be recorded throughout hospitalisation
Number of patients requiring Intermittent Positive Pressure Ventilation in each treatment arm [ Time Frame: Day 1 to Day 14 ]
Details of required respiratory support will be recorded throughout the treatment period
Time to patients requiring Continuous Positive Airway Pressure in each treatment arm [ Time Frame: Day 1 to Day 14 ]
Details of required respiratory support will be recorded throughout the treatment period
Time to patients requiring Intermittent Positive Pressure Ventilation in each treatment arm [ Time Frame: Day 1 to Day 14 ]
Details of required respiratory support will be recorded throughout the treatment period