Cobus Loots, CEO of Pan African Resources, on delivering sector-leading returns for shareholders. Watch the video here.
Bad day over on sng
Sax I know you had some skin in the game over there... Hopefully it will recover or we lift off and you make some of your losses back.
RNS 7am tomorrow... I'll try again
Ot invested here but if it's any consolation in 2018 faron pharmaceuticals who were in phase 3 trials for there drug Traumakine which was to treat ARDS failed even though phase 2 and 1 were excellent results.
The cause of the failure was using cortosteriods at the same time.
There is the issue here.
Average down and batten the hatches for a while and you may well be ok but it hurts for sure the pain today.
The drug no doubt works but they will need to redesign it without steroids
Wow
So their phase 2 trials went really well but phase 3 never worked.
Their RNS reads like ours from 2018
"87% of patients in this trial received systemic corticosteroids for COVID-19 at baseline whereas none did in the Phase 2 study of SNG001 in COVID-19[1]) may have compromised the potential of SNG001 to show a clinical benefit in respect of the primary endpoints for this study."
The drug probably works fine if taken without steroids.
Well we know this...
Here the issue. Corticosteroids messing with the results. Faron pharmaceuticals had the same issue back in 2018 with their infer on beta drug clevergen.
The drug probably works fine if taken without steriods
"87% of patients in this trial received systemic corticosteroids for COVID-19 at baseline whereas none did in the Phase 2 study of SNG001 in COVID-19[1]) may have compromised the potential of SNG001 to show a clinical benefit in respect of the primary endpoints for this study."
RNS tomorrow morning 7am! :)
So faron tweets out a article about bile duct cancer early this morning.
One of the main cohorts of the mantis trials.
Around 30%of paitents benefits from bex as mentioned on the last update
Wonder if they have a bigger breakthrough on this which will be RNSed or mentioned at the investor thingymigig
13:00:10 256.00 50,000 Unknown* 128.00k
"Dr. Fjällskog will share updated survival data from the ongoing MATINS trial and provide an overview of the accelerated bexmarilimab development plan, including a review of the latest biomarker analysis and strategy"
Welcome back onboard the tiny faron float boat.. the tighter the better!
The big trades the past days and even the 60k trade 30 minutes before the RNS came out! Small leak I thinks :)
"approximately one-third of patients in the treatment arm were treated concomitantly with corticosteroids, which abolished a CD73 response in these patients"
That says it all. All along marku was saying the steroids are messing with Traumakine effectiveness.. this proves it!
Remember in 2018 when Traumakine failed. Markus said " never once have I doubted Traumakine works" (or in like words)
"Up-regulation of CD73 was associated with 100% survival compared to expected mortality between 30-40%"
Cant argue with that! Wow!
Wouldn't suprise me if a institutional investor has decided to get on board!
2 trades worth 325k
More TR1s on the cards?
Do you ever feel like you stumbled across one of the big break through in cancer treatment, bought shares in them and just know we are on the cusp of greatness!.
Have paitence fellow brothers and sisters, fellow faronistas... Feb 22nd could well be very enlightening.
My bet is that the next round of I vestments is coming from stateside. In what form I'm not sure.. Us listing? Partnership? But out? Anyone's guess ATm
But one thing is for sure. TIMO LIKE THIS STOCK!
16:41:22 242.70 150,000 Unknown* 364.05k
I always assumed juhu was Markku younger brother. Maybe they are the same person just on a different time line.. It could be true, after all has anyone ever seen them together!?!
31 5000 buys, there's your record!
Lago is lapping up the 5k buys at such a cheap price