Member Info for inanaco

Ruck
These up coming trials are at a far bigger scale than cancer .... and virtually running concurrent

ie once safety approval at phase 1 is granted its all hands on deck ...

Taxman spending £100m is a drop in the ocean on current spending and really i would not be concerned about labour etc taking the high ground on Profits after all vaccines are our business

so a good vaccine induces Memory ..........

Immunobody does that

we are not building a vaccine that treats the condition .. Ray ...

we are building a vaccine that the condition of CRS never arises ...

Scancell Skilled in the Art off .............

Cross-presentation is the ability of certain antigen-presenting cells to take up, process and present extracellular antigens with MHC class I molecules to CD8 T cells (cytotoxic T cells). Cross-priming, the result of this process, describes the stimulation of naive cytotoxic CD8+ T cells into activated cytotoxic CD8+ T cells.[1] This process is necessary for immunity against most tumors and viruses that do not readily infect antigen-presenting cells, but rather intracellular tumors and viruses that infect peripheral tissue cells.[2][3] Cross presentation is also required for the induction of cytotoxic immunity by vaccination with protein antigens, for example, tumour vaccination.[4]

Cross-presentation is of particular importance, because it permits the presentation of exogenous antigens, which are normally presented by MHC II on the surface of dendritic cells, to also be presented through the MHC I pathway.[5] The MHC I pathway is normally used to present endogenous antigens that have infected a particular cell. However, cross presenting cells are able to utilize the MHC I pathway in order to remain uninfected, while still triggering an adaptive immune response of activated cytotoxic CD8+ T cells against infected peripheral tissue cells.

Find the adenovirus that has been shown to cross present .... in Humans

Ray the UK does not have this level of capacity at all ... and what capacity we have will be needed for the next flu jab etc

so it will be built from scratch anyway

Education
DEGREE
INSTITUTION
MASTER'S DEGREE
University of Bristol
PHD
Open University

Ray scancell has staff specific for manufacturing large scale Adrian Parry
(Head of Manufacturing)

https://www.nytimes.com/interactive/2020/04/30/opinion/coronavirus-covid-vaccine.html

https://endpts.com/sp/five-strategies-for-mitigating-the-impact-of-covid-19-on-clinical-trials/?utm_medium=email&utm_campaign=959%20Monday%20April%2027th%20-%20Regenerons%20key%20IL-6%20test%20for%20Covid-19%20marred%20by%20failure%20A%20unicorn-sized%20venture%20round%20grabs%20center%20stage&utm_content=959%20Monday%20April%2027th%20-%20Regenerons%20key%20IL-6%20test%20for%20Covid-19%20marred%20by%20failure%20A%20unicorn-sized%20venture%20round%20grabs%20center%20stage+CID_5db970428d53ec279d450862e4de4b8d&utm_source=ENDPOINTS%20emails&utm_term=Five%20strategies%20for%20mitigating%20the%20impact%20of%20COVID-19%20on%20clinical%20trials&utm_medium=email&utm_campaign=Friday%20May%201%202020&utm_content=Friday%20May%201%202020+CID_8e94d076e3891eac6868c9611e234854&utm_source=ENDPOINTS%20emails&utm_term=Five%20strategies%20for%20mitigating%20the%20impact%20of%20COVID-19%20on%20clinical%20trials

that would be illegal .... Botski

so less conspiracy theory and more actual facts would be nice

Bermuda

I thought the days of ........ """you suggested what i posted""" then arguing with yourself had come to an end ...

"""""Are you suggesting that cancer clinical trials have continued during this crisis?"""

Clearly not ..........

I did not say that ....

its you that looks at every RNS and is throwing in a twist of negative ...

why would you need an RNS to state the obvious ? Government has already informed you a month ago that certain aspects of treating cancer patients would be extremely difficult because of the weakened immune system and the ability to test staff who are treating those patients , these elements now have been hugely improved on over the last few weeks

Bermuda ...

The NHS has already confirmed and indeed is putting the message out ........... we are open for other business

what is clear they are keeping the nightingales open. so lets hope they become the Covid Hubs leaving the main hospitals to deal with the backlog and get patients confidence to enter hospitals again ...

Cancer does not stop for Covid

lets hope that puts the Moral High ground right at the doorstep of Diggles profit taking ...

for those that are unsure how options work

Scancell directors have to take up the options and Buy the shares at 8.15p that cash goes back into Scancells bank account

so in effect they are taking a 25% paycut and as of today with the SP at this level the directors have no gain

so they have incentive's to bring the SP up to claw back the wage loss which we all want, while protecting cash in the bank with a pay Cut .... and increasing the bank accounts cash if they exercise the option .

Yes .......... Clear marker of confidence

actually good for the trials ..... People are now so aware of the importance of testing drugs and have really put themselves forward to test. lets hope they come forward to test SCIB1 like they have for Covid ..

can that cat vaccine be delivered twice or does the cats immune system attack the vaccine second time around requiring a different carrier .. ?

that is important with a vaccine that may need yearly injections ... mutations ...

ie the vector can only be used once

Ivy its also the targets and the ability to bind to the targets ...

Cd8's low affinity ......... are not the same as CD8's High avidity ..