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Now in Covid ......... those patients getting into trouble ....... have a TH1 response coming "to Late" ... just so much virus the immune response becomes so big you are killed by your own immune system which is why Boris was knocked for six ...

Covid is the Ben Stokes on the field at the moment ... it causes CRS ..........

The cytokine release syndrome (CRS) of severe COVID-19 and Interleukin-6 receptor (IL-6R) antagonist Tocilizumab may be the key to reduce the mortality
so this is why they have tried to calm down the immune response ....

now if you have Potent TH1 T cells in memory ............ they don't arrive to late ...

they are ready ...

welcome to Scancells prophylactic vaccine against Covid ...

in one line .........

Scancell are experts in Binding and producing the "perfect " inflammatory T cell ... that is called a TH1 ....

The two helper T cell classes also differ by the type of immune response they produce. While Th1 cells tend to generate responses against intracellular parasites such as bacteria and viruses, Th2 cells produce immune responses against helminths and other extracellular parasites.

so this is what is meant by High Avidity ...............

The affinity by which the antigen is bound to the MHC complex directs the choice of T-cell avidity, as a low-affinity bound antigen requires a high-avidity T cell for a successful response. “Mismatching” a T cell with antigen in such a case would result in improper stimulation and T-cell unresponsiveness.

in English .. if the Covid spikes are low affinity ... producing low avidity t cells just will not cut the through ...

they will not bind ...

Scancells T cells will Bind to poor signals given by the virus .......... because they are of very high avidity ..

this is why scancells vaccine is so potent .. it will kill deceased cells other vaccination programs cannot ...

trust me .. the hardest to treat is not a Virus ... its cancer ... so Scancell is leap up in technology over existing Flu vaccines etc ..

so what scancell is bringing to the table is the Adaptive immune system .....

not just antibodies ...

But Potent Cd4 helper cells and CD8 Killer cells ...

you see its never as straight forward as you think .............

https://www.nature.com/articles/s41467-019-11296-5

so you have to look at who has used Immunobody .... and verified its Potent ...

so look at all the history ...... MHRA know its safe after all they granted the ext to treat melanoma patients for 5 years extension that is 12 doses ... plus

don't forget DNA vaccines can be given over and over as boosters

actually you can bypass the manufacturing stage and use lab built vaccine for the trials because of its known attributes ... ie they made it for testing . this is what Oxford group have done, and have since agreed with Astra Z to upscale production while it is still in trial ..

Throw away the rule book, because everything can run in tandem ... hence

Scib1 was 1 year in manufacture

Covid immunobody will be in trial in 8 months approx even thou its not built yet .. !

however the powers that be inc .. Trent Uni have already proved up immunobody in the prostate vaccine

now back to Covid ....

its the common cold on steroids ........

we don't have a vaccine for the common cold ...

even the Flu vaccine is not that good ....

so you may see many vaccines in development ........... few will succeed exactly the same as cancer vaccines ..

Now if you thing the Big Boys are good at developing vaccines against cancer ... check out the history of failures ...

we can provide you with a list with ease ..

if you want to understand this market chap ... its very simple ...

look at the sales of Keytruda and Opdivo .. from a standing start a few years ago ....

look at the range of cancers they can treat and the toxicity generated by them ....

now look at the interest in the market combining Keytruda with a Vaccine ...

thats immunobody ...

Moditope does not need Keytruda and if its as effective as we suspect ... it opens up the entire cancer market for Moditope ..

a Potent last resort vaccine because it only works when the patients cancer has grown significantly because its target is "stressed cells"

every one is talking in the Covid game as Targets ... the spike protein ...

In cancer those protein targets are very few and far between ...

so when somebody finds a target ... it has enormous value ...

Moditope is that target protein ... but its on the majority of cancers

and in the mouse model ......... they don't die

Tony ...

watch this first it will give you a better understanding of the basics

https://youtu.be/zogJ2CCmOxY

Ok .. i am from Brum but now Devon based, the owner of the Exeter chiefs is Tony Rowe OBE and loves fire engines

Tony ........ scancell is a very complex share involving multiple platforms ie the Covid vaccine is part of the immunobody family
but the really exciting platform is Moditope ... which brings in to play for the first time the CD4 Killer cell
scancell owns the patents for all the major cancers using this technology ... it really is wow wow stuff

what area are you from Tony ? and do you have an interest in Fire Engines ?

Balerno that is the way it tested ... one step at a time ... = 1 year

to speed things up, you test all at the same time ... more expensive .. but very quick

Bermuda maybe another advantage to the SCIB1 and 2 trial then ....

just remember everyone is now talking about the next phase

not just a second wave from Covid

but the knock on effect of the first cancer death wave caused by Covid interference with identifying and treating existing

Think ahead ...........

Radiation, Chemo, even with PD-1 combo ================= lower's the immune system .. high risk of Covid

Vaccine plus PD-1 ............. low risk , Immune system is boosted

indeed Scancells approach solves the problem of treating cancer patients in a pandemic

Moditope ....

If Scancell pulls off a tie up with Immunobody with a major player ...

can you value that .... ?

its not just Covid that would get the "prestige" but all the other immunobody projects

Prostate
Brain
Skin
Lung

Cancer

i was thinking Lammy .. who has a Boris replica with excessive piercing ....

Boris Johnson and Carrie Symonds have announced the birth of a "healthy baby boy"

another Boris .... that will upset some LOL