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oops double paste .. sorry

well shock horror ........ herd immunity can be achieved by natural spread of the virus .,..

whats also good news ...

it sets the bench mark for a vaccine

An understanding of protective immunity to SARS-CoV-2 is critical for vaccine and public health strategies aimed at ending the global COVID-19 pandemic. A key unanswered question is whether infection with SARS-CoV-2 results in protective immunity against re-exposure. We developed a rhesus macaque model of SARS-CoV-2 infection and observed that macaques had high viral loads in the upper and lower respiratory tract, humoral and cellular immune responses, and pathologic evidence of viral pneumonia. Following initial viral clearance, animals were rechallenged with SARS-CoV-2 and showed 5 log10 reductions in median viral loads in bronchoalveolar lavage and nasal mucosa compared with primary infection. Anamnestic immune responses following rechallenge suggested that protection was mediated by immunologic control. These data show that SARS-CoV-2 infection induced protective immunity against re-exposure in nonhuman primates.

so if you do come into contact with the virus you "SHOULD" not get infected ... ie the Virus should not get a foothold

An understanding of protective immunity to SARS-CoV-2 is critical for vaccine and public health strategies aimed at ending the global COVID-19 pandemic. A key unanswered question is whether infection with SARS-CoV-2 results in protective immunity against re-exposure. We developed a rhesus macaque model of SARS-CoV-2 infection and observed that macaques had high viral loads in the upper and lower respiratory tract, humoral and cellular immune responses, and pathologic evidence of viral pneumonia. Following initial viral clearance, animals were rechallenged with SARS-CoV-2 and showed 5 log10 reductions in median viral loads in bronchoalveolar lavage and nasal mucosa compared with primary infection. Anamnestic immune responses following rechallenge suggested that protection was mediated by immunologic control. These data show that SARS-CoV-2 infection induced protective immunity against re-exposure in nonhuman primates.

https://www.sciencedaily.com/releases/2013/04/130411142815.htm

this current crop of vaccines target B cell memory ... because the spike protein is only on the virus .. a T cell is blind to the virus ... because its searching for cells infected with the virus , exactly the same as cancer a protein on a cell will identify itself to the immune system "i am in trouble"

so to knock out the virus you neutralize it , but that does not stop an infected cell shedding 1000's ... which have to be neutralized

so that is the job of t cells and NKT cells they will clear infected self cells ... and destroy them

the virus cannot hide unless it can mask itself ... but it can do that as well .........

when a virus cause chronic infection ....... our good friend interferon ............ becomes a problem

https://www.sciencedaily.com/releases/2013/04/130411142815.htm

Dendritic cell again ... Ray it handles B cells as well

B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype. They function in the humoral immunity component of the adaptive immune system by secreting antibodies.

bermuda ........

i am not miss representing ...

you are trying as your post eluded to balance ............

i am balancing that out further

Bermuda ... maybe you should question those using your name .. Knowlesi

he is using your name and your post in his never ending posts trying to get the SP down

i reply to knowlesi ...

as i have explained so many times

the target was easy to find ........ inovio did it in 3 hrs

it's the platform that presents it is the difficult bit ..........

scancell has over 15 years experience with this area ... because its platform had to over come Cancer ,... which is far more difficult that a virus

for scancell is a step down ...

for oxford its still a step up ........ it failed to deliver ..

https://www.nature.com/articles/s41467-020-16505-0

filibuster is used to eat time ....

this bb has no clock

further to Kowlesi post ........... i agree Scancell barely mentioned ............ apart from the "gulf" bit ... which i have shown to be Garbage ...

as Platforms present to the immune system ... and that is the Key ... which opens the immune system

great target the Spike ........ poor platform = rubbish results ...

so "i don't think you can compare" ............. should have been "i am unable to compare" because I did compare !!!

the rest is an advertisement for Oxford ....

Bermudashorts

Posted in: SCLP

Posts: 10,612

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RE: UK appoints Kate Bingham as chair of its Covid-19 vaccine taskforce18 May 2020 21:08
Sorry WTP but I don't think you can compare Oxford's vaccine with Scancell's - there's a gulf between them in development terms. Have seen lots of comments regarding ChAdOx1 on the bb today and think some balance is needed.

You may be right and nepotism may be at play here. On the other hand, if you were a scientist advising the Government on the best vaccine candidates to fund, the following might be valid reasons to choose ChAdOx1 .

1) Oxford had already developed ChAdOx1 for another coronavirus (MERS)
2) It had already been through Phase I trials for MERS, had shown that it was safe and shown encouraging signs of efficacy
3) Based on that clinical trial it had been taken forward into clincial trials in Saudi where MERS still rumbles on
4) The Oxford team started working on converting ChAdOx1 for COVID-19 in early January, even before the Chinese revealed that there was human to human transmission
5) It's not self-replicating making it safer to give to children, the elderly or those with pre-existing conditions

The speed with which the Oxford team have moved this vaccine into the clinic is astonishing and a fantastic achievement. We don't know whether the trial will be a success, partial success or outright fail but even today it's the only UK candidate in trials. I wonder what folks would have said if an existing coronavirus vaccine from one of the (if not the) top universities in the World was left on the shelf due to lack of funding?

This is the Scancell BB ....... developing a Covid vaccine

3 weeks ago i gave this BB my opinion on the Oxford team identifying failures that have occurred in programs that they have invested in

i explain in depth how we differentiate between different vaccine developers

because the Gov as we have been told will invest in Vaccine programs .....

at present we are using "shareholder funds"

so we have to look at the commercial advantage of that investment ...........

to do that justice we have to consider the competition as competition .............

if those that wish to defend Oxford's state funding case over scancell in this instance should accept that

if they get all upset because they cannot break down my argument ... well that is life ... classic ending ...

what to help you attack scancell .........

that tweet will upset some posters ..

The factory the Government is building can build Scancells DNA vaccine ... as well as RNA vaccines and Lentivector

https://youtu.be/GQUCCkHNjN8

look at the magnification ......... 1,000,000

https://youtu.be/7Hk9jct2ozY

that is the defense mechanism inside the cell .... this is why Doctors talk about Viral Load ....

so if only one virus entered your body and got into a cell .... the odds are the cell itself can handle it ...

but if 100 or 1000 got in .............. one will get through

if the BBC ever replay this ......... its the one to watch https://youtu.be/v1MnNO4I9aU

spot on C7 ....
the intrinsic value is still there ... and because of the fall in the SP it makes the investment at this level compelling ...

and Scancell continue with the research programs and as we have come to expect .... research throws up surprises

Homocitrulline
Avidmab
TCR

all come about because Scancell is a research based PLC