Member Info for inanaco

just for you Ruck ........ Moljen got it

"""So, flu new vaccine every year cos little nasty virus mutates, if our stuff works no new jab each year because we target and kill the nasty little buggers core not the spot it has developed.

Simples always beats complicated """

ATB ....

Flah I enjoy learning the technical stuff .. it makes investing easier, i am not an expert by any means

in a nut shell ....

general intrinsic mechanisms : intrinsic mechanisms induced when the TcR engages MHC–antigen-peptide complexes are a major point of control over the magnitude and class of immune responses. One of these mechanisms entails the avidity and duration of binding of the TcR with MHC–antigen-peptide complexes — avid binding of relatively long duration favors activation, whereas a weak, brief encounter does notref1, ref2. Notably, engagement of the receptors can induce not only activation and differentiation of the T cell but also apoptosisref. Control of antigen-induced activation of T cells by intrinsic mechanisms : homeostatic control mechanisms are induced during the initial activation of all T cells when the TcR engages complexes of MHC and antigen peptide. T-cell activation depends on the avidity and duration of binding of the receptor to MHC–antigen-peptide complexesref1, ref2, as well as on costimulatory molecules (e.g., CD40L, CD28, and CTLA-4). These initial events influence the outgrowth, function, and death of T cells, as well as their differentiation into subgroups of helper T (Th) or regulatory T (Tr) cells that secrete distinct arrays of regulatory cytokines.

so the only thing that changes between a virus and cancer is the marker

hence a cancer platform targeting a virus is far more potent than a normal vaccination

which is why we have great potential for an over 55 vaccine which needs to be stronger than normal

michael ... read it again ...

broadly speaking, is the idea to get the virus stuck on the surface of a cell and not let it go inside the cell to destroy it?

we are not targeting the whole Virus ... but markers on it

its these markers in RNA and DNA that the vaccine is looking to present to the immune system

the advantage is you control how the adaptive response is activated

To broaden the application of this vaccination strategy, 16 NY-ESO-1 epitopes, covering over 80% of HLA phenotypes, were incorporated into the IB (SCIB2). They produced higher frequency and avidity T cell responses than peptide vaccination. These T cells were of sufficient avidity to kill NY-ESO-1-expressing tumor cells,

so Scancells approach Generates all that the immune system requires

Cd4 helper T cells
Cd8 cytotoxic T cells
and
Neutralising antibodies

so scancell as we know can load a single DNA plasmid which as far as I am aware with up to 16 targets

SCIB2 has 16 targets

now this is the important bit .......

scancells approach is very similar . your body makes the immunobody .. so only the DNA Plasmid instructions are given

but the RNA requires needs an innate response to the target antigen which then starts the process of an adaptive response

"""When the antigens appear on the outside of your cells, your immune system attacks them—and learns how to defeat future intruders in the process. You essentially turn your body into its own vaccine manufacturing unit."""

so the information is digested by the DC's .. which then encodes the T cell .. which is fine

what its not giving you is a high avidity t cells

so scancell DNA plamids start releasing antibodies which contain all the instructions to give to the DC ....

at the same time the DNA plasmid is fired into the DC so receives its first instruction then an Immunobody locks on to the same DC and instructs it again ... "Cross presentation"

now because the DC and the surrounded area are damaged by the ballistic particles Cytokines flood the area which has an affect on the way the DC activates the T cell (adjuvant) ......... it polarizes it to High Inflammatory and because of the cross presentation it gives the T cell a lot longer latch time onto the DC which promotes the Avidity ...

which is why i am always confident about Scancell ...

moving at a pace

T Cell data

https://www.fiercebiotech.com/research/curevac-ramps-up-covid-19-mrna-vaccine-effort-as-moderna-analysts-raise-questions-about?mkt_tok=eyJpIjoiWldOaE5UQTFORE5qWm1SbSIsInQiOiJFc0Nmc1RwQ3BkOXc1TlI3MkdkbkRhXC83eUMrTFM5VlwvaWY3dFhNcVd1WmljZ1wvbTY2WUQwZjRWa3NhMzRBbEdtMVN1dTFya3lqMHduOERJOEVNQWV4SmJCVUttcW5iVGRDUlhxYlVmYzB3b0p4ZFp0OGFjeTlBeGpFVmVId1g1RyJ9&mrkid=652336

more representative than Lammy ....

conservatives did win

well if i managed to consider the data presented looked a bit suspect ...

why cannot the Government .. ?

and i cannot understand somebody making a major statement but not agreeing with it ...........

that bit is my comment sorry

we took pelham ...

fair comment ..

just might add thou ...

this post started the tit for tat ..

Bermudashorts

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RE: UK appoints Kate Bingham as chair of its Covid-19 vaccine taskforceToday 09:04
Inanaco,

Jesus wept, I'm not going out on a limb and I'm not defending the vaccine. I have said over and over that it may fail. I have also said wait for the trial results.

I'm really not going to enter into any further debate - carry on bashing.

and i cannot understand somebody making a major statement but not agreeing with it ...........

then why post this stuff ...

yes Moljen ....

it recommended using a poor vaccine .. ... that is a statement i expect from Trump .. not Bermuda

"""it may be, as with the monkeys, it prevents development of pneumonia and lessens the symptoms so that they may be no worse than a mild cold. As mentioned before, this vaccine should be safe for the elderly and those who are vulnerable due to pre-existing conditions - there are many people, including children and the elderly with pre-existing conditions who can see no prospect of a return to normal life due to the risk of COVID-19 and complete social isolation is no life at all. In the short term, if we get no more than a vaccine that lessens the symptoms, it would allow the country to return to normality while we wait for the second wave of vaccines and hopefully Scancell will be part of that. """

i will just remind you i question the efficacy of the Oxford approach back at the end of April .. before the recent study release

inanaco

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RE: Investment in Research30 Apr 2020 16:22
I am only doing comparisons Bermuda .. if the data presented by them so far was great it would jump off the page ... it does not

Scancell data has done that .........

yes independent thought

Professor Jonathan Van-Tam said the country had to prepare in case Covid-19 deaths fell throughout the summer but came back in the autumn and winter.

Only once there was a vaccine that is "really capable of suppressing disease levels" will the country be "out of this", he said.

bermuda ... then challenge the posts directly ...

rather than creating a new thread ...

which is why i have pulled you up today

and the last thing we want is a post to be discussed ..... or challenged

after all that is not what the BB is for

Right ?