Member Info for inanaco

agm or egm ?

its two different things ...... chronic inflammation and inflammation ..

using Vit d to control chronic by up regulating CD regulatory T cells which suppress is Good ...

but you would not want that at the start of an infection ... but only if it becomes Chronic ..

having read that ......... my advice if you do receive the Covidity vaccine or any of Scancells vaccines .. do not take Vit D ...

last thing you want is Regulatory suppressor cells

Dendritic cells (DCs) are the most potent antigen-presenting cells. A number of studies have shown that 1,25(OH)2D3 inhibits the differentiation, maturation, and immunostimulatory capacity of human DCs, characterized as the tolerogenic properties, in a VDR-dependent manner.29,30 Molecular mechanisms underlying the modulation of tolerogenic properties of DCs by 1,25(OH)2D3 include decreasing surface expression of major histocompatibility complex II and costimulatory molecules (CD40, CD80, CD86), upregulating inhibitory immunoglobulin-like transcript 3 molecules, and enhancing secretion of chemokine (C–C motif) ligand 22 and IL-1029,31 (Figure 2). The enhancement of DC tolerogenicity by 1,25(OH)2D3 results in the induction of T-regulatory cells, a critical event for suppressing the inflammatory response of T-effector cells

Bunsie ...

I would pick up the phone ... and not wait

LOL ... i have no control of his movements ... or have a clue of his position in space time ...

what i can tell you, you are never in the same place twice

CH .. is in Spain ..

maybe CH is busy signing autographs at his lawyers office

something is going down ............................................. a delay for a month ? right in the middle of an OO ....

well not much going on today ....... i Guess its the 6 o'clock news tomorrow that is of interest ...

Bunsie battery is running down ... while he speaks to HSBC

for Share buying press 1 .......... answered immediately

To open a new account press 2 ... answered immediately

for all other options please hold ... and wait for a suitable agent working from home while baby sitting ... who probably does not have a clue what you are talking about ...

battery life low ...

any T cell against Self ............... is massively destructive ...... the reason why they are particular bad is because they can inflame they are generals ...

exactly what you need against cancer .......... but that does not mean these T cells induced by Moditope will attack Self
because you have a repertoire for them

bugs .............

inanaco

Posted in: SCLP

Posts: 32,136

Price: 6.90

No Opinion

RE: Knowlesi ... reminder ..29 Jul 2020 08:04
as a contrast to that ............. you cannot patent the spike protein of cronovirus ... you can patent the vaccine but you cannot patent the target .. so anyone can build a vaccine ....

the value is Who does it best ... ?

Tick Tock

you will see another post ... but its not listed on the thread ... ??

as a contrast to that ............. you cannot patent the spike protein of cronovirus ... you can patent the vaccine but you cannot patent the target .. so anyone can build a vaccine ....

the value is Who does it best ... ?

Tick Tock

honestly ....... most have no idea what will happen if Moditope works .............

"""So moditope patents the targets ... because to access them you need to modify the epitope to make it visible thus the target itself has a patent ............mod = modified ... tope = epitope """

land Grab

so the best plan now is to count up Scancells targets ... and specifically the targets that can only be accessed by "modified Mabs" its all about what you can Patent to make it secure

So moditope patents the targets ... because to access them you need to modify the epitope to make it visible thus the target itself has a patent ............mod = modified ... tope = epitope

as you can see from that link others are also targeting the Trop2 ................. yet it still commands an enormous price

yet you are looking at scancell ........... completely blinkered to its actual value AZN product needs to carry a payload of toxic substance to kill the cell ... expressing Trop2

Tick so can Avidmab

but avidmab goes further ..............

In addition, Scancell has acquired a third proprietary technology, AvidMab™, that confers potent direct tumour cell killing properties to humanised monoclonal antibodies (mAbs). Scancell has used this technology to produce a number of cytotoxic mAbs that recognise glycan-containing glycoproteins and glycolipids on the cell surface of cancer cells.

dont you get it ?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402435/

well .......... Knowlesi .. take a look

The search for an ideal cancer-specific protein for targeted therapy has been ongoing for decades now. The Trop-2 oncogene is an ideal target for therapeutic development and ADCs, as it is ubiquitously overexpressed across solid tumors and is membrane bound with an extracellular domain. Moreover, in vitro testing of Trop-2-targeted therapeutics has been favorable, with certain Trop-2 ADCs demonstrating subnanomolar IC50s.44 Several animal models and human clinical trials have demonstrated tumor suppression and favorable therapeutic indexes with Trop-2-targeted therapy. As such, the future of Trop-2 as a therapeutic target appears promising.

the reason why i am asking now Knowlesi ... lets take the So called 20p ... but reflect that to the AZN billions poured into one MAB deal ..
Do you understand this business is all about "find a target" and what this demonstrates is the Value of a target linked to a platform that can engage it

so why has AZN decided to pour so much money into 1 target with only a phase 1 trial in progress ????

have you ever considered researching why ???

I did not insult you Knowlesi .. only posted facts .. ie your predication did not go to plan .. so have you changed policy ?

Ivy sold down now he is buying ..

same principle ..

and Ruck has never baited any one ..... and pigs do fly