Member Info for gixer

Below is some of the links, mainly relating to By-Health and Fruitflow (Water soluble tomato extract) found over the last year or so.
In no particular order but includes Patents, Study trials, Publications and presentations.

https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020077747&_cid=P10-K9F8JJ-45635-1

http://www.cnki.com.cn/Article/CJFDTotal-ZSYK202002011.htm

http://www.chictr.org.cn/showproj.aspx?proj=27048

https://www.researchsquare.com/article/rs-17401/v1

http://www.zhuanliqiao.com/zlqiao/patent-c185aaeb57da4dcfa9da1f146ee78bda.html

https://m.fx361.com/news/2019/1205/6076972.html

https://postimg.cc/VdjqqLqL

http://www.asiadrug.co.th/en/news/detail/47-heart-and-health-seminar

https://patents.google.com/q=%22water+soluble+tomato+concentrate%22&oq=%22water+soluble+tomato+concentrate%22&sort=new

http://www.wjtcm.net/article.asp?issn=2311-8571;year=2019;volume=5;issue=4;spage=260;epage=268;aulast=Zhang

http://www.chictr.org.cn/showprojen.aspx?proj=22104

http://www.chictr.org.cn/showproj.aspx?proj=27052

http://www.chictr.org.cn/showproj.aspx?proj=27048

http://by-health-portal.oss-cn-shenzhen.aliyuncs.com/files/20190329153915912_jkbg[2018].pdf

Cheers BB, I knew there was a way to do it but couldn't remember how.

wellsite, Well spotted on the postmark but I must say that I don't remember seeing this presentation document before.

Title :- New trends, new ideas, new models, cooperation and innovation, a win-win future

Cant figure out when this presentation is from but clearly has a big focus on Fruitflow from page 14. Provexis also gets a mention on page 13.

https://www.exiaotuan.com/skin/default/11.1/zxg48.pdf

Its not improved his memory then lol

I know people can write anything on these review sites but was hoping pxs might reply.

https://www.trustpilot.com/reviews/5ed4de2625e5d20a88a4662b

You are going back a bit....
Best you check back on the website.
https://www.provexis.org/regulatory-news/

https://otp.investis.com/clients/uk/provexis_plc/rns/regulatory-story.aspx?cid=1569&newsid=1351875

Been keeping out of the Fruitflow / Covid-19 discussions as quite frankly the science is way above my head. I did however find wheelds link interesting and the connection to endothelial cells.

“What we’re saying is that maybe the best antiviral therapy is not actually an antiviral therapy. The best therapy might actually be a drug that stabilizes the vascular endothelial. We’re building a drastically different concept.”
https://elemental.medium.com/coronavirus-may-be-a-blood-vessel-disease-which-explains-everything-2c4032481ab2

"Tomato Aqueous Extract Modulates the Inflammatory Profile of Immune Cells and Endothelial Cells"
https://pubmed.ncbi.nlm.nih.gov/26840280/

"These water-soluble tomato components were also found to inhibit angiotensin-converting enzyme (ACE) and to relax the vascular endothelium, the other important limbs of the cardiovascular system"

"This Fruitflow® inhibits the activation of macrophage and endothelial cells, which could help to reduce leucocyte recruitment and promote a reduction in tissue inflammation"

Fruitflow®: the first European Food Safety Authority-approved natural cardio-protective functional ingredient.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334395/

Lots more on endothelial cells in the above publication, all I need now is for someone to explain it all to me.

"The two completed studies (a human study and an animal study) showed excellent results in use for Fruitflow®,
and BY-HEALTH intends to make its first blue cap submission to the SAMR for Fruitflow® in February 2019,
with a further blue cap submission envisaged later in 2019, both to include references to the Company’s
existing European Food Safety Authority (‘EFSA’) health claim for Fruitflow."
https://provexis.org/wp-content/uploads/2018/12/PXS_2018-11_Provexis_plc_30-Sep-18_interims_31-Dec-18.pdf

Sphinx, I am hoping that the studies are for more than one health claim. Guessing blood pressure reduction being one.
An earlier RNS did indicate to at least 2.

"Although the article is a year old it could explain the delay for at least one health claim."

delay is the wrong word to use as we don't know that there is one. However it would be nice if the company could give us a bit more info on Blue Hat.

Thanks Bella,
Although the article is a year old it could explain the delay for at least one health claim.

"the review also suggested to relook health claims that require further research evidence. Six claims, which include “aids in lowering of blood pressure” ?and “aids in lowering of blood sugar”?, would be affected."

"Regulatory advice ?
Regulatory experts have advised manufacturers to halt the R&D of products that bear claims which may require additional scientific research. This was because these claims might not be approved eventually, thus, if manufacturers were to proceed with R&D of these products, their past efforts would go down the drain, Charles Diao, regulatory manager at US-China Health Products Association told NutraIngredients-Asia."

https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020077747&_cid=P10-K9F8JJ-45635-1

https://www.positivepause.co.uk/all-blogs/why-does-the-loss-of-oestrogen-through-menopause-have-such-an-effect-on-womens-bodies

Life-Space was bought by By-Health on the 30th of August 2018 and already have dual health-care functions of "regulating intestinal flora" and "boosting immunity”

Provexis and DSM partnered with By-Health on the 18 November 2016 and we still dont have any health claims :(

I can only think that probiotics were already approved in China making it quicker and easier for By-Health to get the approvals.

Well from the end of last year but just found it.
https://www.just2bfit.nl/vitflow/

https://xinyingyang.com/16634/

China

Biogrow on Fruitflow.
"What is a stroke"
https://youtu.be/N68wywrlzms

Just a reminder of some (all?) of the products found since December

103/ Sop Subarashi triple peptide June 2020

102/ Blood pressure formula May 2020

101/ Cardio Flow Puravida April 2020

100/ Biogrow SmoFlow capsules April 2020

99/ SIRKULINUM Jan 2020

98/ HAPPY HEART Jan 2020

97/ Cardiopro Dec 2019

98/ Speed flow Dec 2019

Jethro
I will try and answer your questions but others might know better.
1. Original fruitflow liquid was produced in Italy and Fruitflow II was produced in France by Indena SAS. I have heard both can now made on the same site so would guess that is France.
2. Yes
3. Fruitflow has been used in juice by a few brands but has never appeared to be very successful in that form. It has never been in a carbonated drink as far as I am aware so don't know.

DSM would be the best point of contact.