Exosomes18 May 2017 08:19
esents positive exosome data at major conference
Thu, 18th May 2017 07:00
RNS Number : 4700F
ReNeuron Group plc
18 May 2017
AIM: RENE
18 May 2017
ReNeuron Group plc
ReNeuron presents positive pre-clinical data with its ExoPr0 exosome therapy candidate at major scientific conference
Data show that ExoPr0 can cross the blood brain barrier and can potentially target multiple diseases via local or systemic administration
ReNeuron Group plc (the "Company") (AIM: RENE), a UK-based global leader in the development of cell-based therapeutics, is pleased to announce that it will be presenting new positive pre-clinical data relating to its ExoPr0 CTX cell-derived exosome therapy candidate at a leading scientific conference.
In this poster presentation, ReNeuron researchers will describe studies undertaken to investigate the in vivo biodistribution of ExoPr0, using the most common and disease applicable routes of administration to deliver the exosomes. The studies showed that ExoPr0 can be targeted to specific organs and tissues by either local or systemic administration. The uptake of ExoPr0 by particular cell types in target organs suggests that there also may be some specificity in uptake at the cellular level.
ReNeuron has identified the potential of ExoPr0 as both a novel therapeutic candidate and as a drug delivery vehicle, based on earlier research to demonstrate the ability of ExoPr0 to modulate fibroblasts, immune cells and cancer cell lines in vitro. This earlier work, together with these new findings showing that ExoPr0 can be targeted to specific tissues and organs and, most importantly, can penetrate the blood brain barrier, suggest that there is significant potential to develop ExoPr0 for the treatment of multiple diseases.
The above findings are being presented today at the International Society for Extracellular Vesicles (ISEV) 2017 Annual Meeting in Toronto, Canada. Further information about this conference may be found at www.isev.org/page/ISEV2017
Dr Randolph Corteling, Head of Research at ReNeuron, said:
"We are very encouraged by the findings being presented at the ISEV 2017 conference relating to our ExoPr0 exosome therapy candidate. The ability to target ExoPr0 to specific tissues and organs, including the brain, via clinically relevant routes of administration is highly significant. This, together with other recent positive data we have presented relating to the characterisation and scale-up potential of our exosome therapy candidates, clearly demonstrate the potential of this novel therapeutic platform to target multiple diseases."