Others have tried.14 Sep 2022 16:10
I remember AS mentioning
FAP activated pro drugs have been tried but no one has succeeded.
Take a look at this research paper
Authors 117,127,129 interesting they were 2015 and 2016
https://www.frontiersin.org/articles/10.3389/fonc.2021.648187/full
Other mouse and dog models have revealed that doxorubicin conjugated to a FAP substrate has significantly lower toxicity and greater safety relative to the toxic effects of free doxorubicin on the heart, liver, kidneys, spleen, and peripheral blood leukocytes. Moreover, the same dose of the doxorubicin-conjugated formulation is associated with a 2-fold increase in intratumor accumulation. In the clinical trial stage, it was found that Z-Gly-Pro-Dox is difficult to dissolve in water (117). Zhang et al. (129) designed a nanomicelle system (ZGD-MNs) to promote the systemic administration of Z-Gly-Pro-Dox. A physiologically based pharmacokinetic model was used to evaluate its distribution in rats. The study found that ZGD-MNs are reasonably stable in phosphate buffer, showing good physical and chemical stability during the observation period of 2 weeks, and the cumulative drug release rate within 24 h was over 56%. Ji et al. (127) have designed a new cleavable amphiphilic peptide that specifically responds to FAP on the surface of CAFs. The peptide spontaneously assembles into fibrous nanostructures in solution, which can easily be converted into drug-loaded spherical nanoparticles. These nanoparticles break down in response to FAP activity, resulting in rapid and effective drug release at the tumor site.
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