Cellbxhealth. Could parsortix be used to find the best8 May 2026 12:41
Candidates for the Astrazeneca cancer drug truqap?
AI Overview
Yes, the ANGLE plc Parsortix® PC1 system can be used to identify and monitor candidates for AstraZeneca’s Truqap (capivasertib), particularly by analyzing circulating tumor cells (CTCs) for specific biomarkers.Parsortix is a liquid biopsy system that isolates and harvests intact cancer cells (CTCs) from a simple blood draw, enabling "real-time" assessment of tumor characteristics without needing invasive tissue biopsies.Here is how Parsortix technology relates to finding the best candidates for Truqap:1. Identifying Specific Biomarker Alterations. Truqap is approved for HR-positive, HER2-negative advanced breast cancer patients who have specific gene alterations: PIK3CA, AKT1, or PTEN.CTC Analysis: The Parsortix system captures intact CTCs from blood. These captured cells can then be used for downstream analysis, such as identifying the presence of PTEN loss or PIK3CA/AKT1 mutations.Advantage over ctDNA: Unlike circulating tumor DNA (ctDNA) which only provides genetic mutations, Parsortix harvests intact cells, which allows for a more detailed analysis, including gene expression (RNA) and protein levels (e.g., PTEN protein loss).
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https://www.lse.co.uk/rns/AZN/fda-odac-recommends-truqap-in-prostate-cancer-a0vpgaettfsc8cv.html