RE: South African Covid variant hits London13 Apr 2021 02:06
I don't advocate delay I am pro any affimer test asap to feed data into the experiment. The risk element was in my calculations a long time ago as in fomo. The government has both helped and hindered. It has standardized a test and put us in the frame but both them and AS are chasing the impossible dream instead of allowing affimers to be openly validated in use.
The Government is playing it badly too as sidelining the market in favour of validating or not all tests put forward- they are giving themselves unecessary work.. Will all tests remain effective and they have sort of valdated Innova so the bar can't be too high. I remember a poster saying a major pharma got it's start from an innefective drug that regulators passed. I trust AVCT to alter their test as required as this is the sales pitch that affimers have so need to ring fence one particular LFT. The S&S one day may not be the same a month later. I don't think there will be many tests to challenge ours but there is actually no need for prescribing test parameters as they will buy the best and the public can't, I imagine, passport with all tests, they will be approved ones. The Government is part of the market and will not buy tests to provide free eg for the NHS if they do not like the product. When we get ISO we will be truly able to go it alone for ours and others tests and is potentially a very good move. Good thing beheadings are no longer around as a show I can therefore avoid starring in.
RE: The right strategy would have been12 Apr 2021 18:03
jdt; the improvements to the test would be in response to the mutating virus. A narrow remit with covid can only be applied for the pandemic on a particular day and even that will be late. Affimers appear to be the quickest way to respond to mutations. A test can only be measured in use and the government thinks Innova is pretty good as does Mina but I think ours would be better for curbing spread in a test for back to normality in society (plus regular test) scenario. Lockdowns are not an option and a whole year of affimer tests has been wasted imo.
RE: The right strategy would have been12 Apr 2021 16:55
jdt; that unfortunately is a failed procedure. It is precisely because I want to see affimers applied in myriad directions that the most simple of measures has to prove how good they are so get a test out there.
RE: The right strategy would have been12 Apr 2021 16:43
Affimers are specific and early to detect so a test out there will prove that point. Preferably saliva, wherever As can get it on the market. Speed is of the essence with this virus so address the imperative not the regulators narrow remit and then in the market you have a test you keep tweeking to improve it. The government have been bending the rules for CE marked tests so trained staff can oversee.
The right strategy would have been12 Apr 2021 16:28
The right strategy would have been to get an antigen spike test on the market and selling with the data collected as per innova for a straight head to head. The proof is in the pudding not the regulators lab. Apparently it is the easiest thing to do unless you are AS. It does not matter about the S and S just what the test does in use. I believe in the affimer if it ever sees the light of day.
Why has AS made the S protein test a hostage to Mologic then. Falcon should set up an outpost in India and Brazil as the government - was it for £55,000 will do validation then maybe they can finish off our validation. Do we have to pony up 55k? The government wants a global leader so get out there and win some fans.
You mean(and I suspect) AS did not draw up a collaboration with Mologic specifying the S protein test as conditional before an S/N test which is supposedly, if he ever gets one out, to prove from data in use that it can control the pandemic. I don't mind a S/N test but would like AS to actually do something with affimers only or doesn't he really believe in them. If he can't dot the Is and cross the Ts he will be walked all over and he needs a test for the S protein using affimer reagent mixture to prove his laboratory data. Maybe affimers can detect the N protein too together with some Mologic chemistry but we would be halving the reagent profit take and not showing what AVCT can do on its own. He should nip out to Brazil and see if he can get something saliva based up and running quickly where there are plenty of infections.
Just proves BJ and Whitty do not understand the subject. They should be able to do this as a matter of course from the podium as it underpins their whole strategy. The population will not listen to this new appointee.