Member Info for Doc.Daneeka

" Synairgen are amongst the dozens of organisations forming the vision. " absolute classic :)

Too little too late I'm afraid - and of course nothing to do with Synairgen which has never been supported in the UK - beyond the minimal assistance all trialing companies receive. Would still like to know what the Porton Down tests were about - but that avenue of exploration has ended in any case.

"The number of Phase III industry trials initiated in the UK – those with medicines closest to market – fell by 48% between 2017 and 2021

The UK has fallen down the global rankings for late-stage clinical research, dropping from 2nd to 6th in Phase II trials and 4th to 10th in Phase III trials between 2017 and 2021

PMJH is bullish and optimistic as per usual - but cutting and pasting the same lame and meaningless company paragraphs is not insightful or helpful at this point. We've read them many many times and do not need reminding.

All that matters is that they said patients for the MV trial are easily identifiable - which means they still haven't found someone to support it. Not holding the AGM as this process continues is pathetic.

Mani I think your use of the word "compass" - given the widely publicised and tragic events off the coast of Sicily this week is in poor taste. I hold you'll withdraw the word

It was certainly in bad taste poetically and musically Mani. Not remotely offensive otherwise.

I'll take you at your word Karley. Welcome to the board - you're 3 years too late for the champagne and fast cars I'm afraid but salut anyway

Very odd. Let's see what MC says

Haha Aether I thought it was Karley Simon - but you're right. Fruits - Tommy - Gun - now this really is a multiple account and neither of them have any shares

I meant the data hasn't supported the main thrust of research and endeavour since Sprinter. That's unarguable. The project came to an end. We'll see if it supports a trial in MV

This is spiralling down some very dark passageways. It's possible to criticise the BoD without suggesting corruption or making any of these ridiculous accusations. We've come full circle from the days when supporters talked about group actions against MHRA for overlooking SNG - but I'm sure everyone at Synairgen is still doing their best. It's just hasn't happened for them or us. It is now clear that Richard Marsden should have fallen on his sword after Sprinter. He took us down an ambitious road which the data just hasn't supported

SD1 If Hold came back we'd be treated to better than this miserable fare. Taylor Swift whiney drivel and some nonsense boyband sea shanty. Was a time when Friday Tunes meant something .....

You're embarrassing yourself again Fruits - and proving my earlier point about constant calling out of well-respected LTHs. They don't come in much higher regard than Doc83 - but you've now added him to your list of multiple account posters. Let's tally his contributions to this forum against your own miserable sniping................

Go for a walk - mow the lawn and come back after the Bank Holiday

Well done Jonnyboy

Wpa5 many of us invested for the same reasons during the pandemic and I've written the same about our hopes that this investment would also help the world in a very dark hour. Beyond that I diverge on almost everything else you've said.

It's been clear since Sprinter's failure and the subsequent suspension of ACTIV2 that the old " we know it works " line is no longer accurate or of relevence. The salient question since then is "how well does it work ? " and the evidence to date says that in outpatients and general population inpatients it does not work well enough. That's why NIH has offered no further trialing since ACTIV2 and it's now why the companies own plans and ambitions as a multi-viral variant agnostic therapeutic have come to an abrupt end. The global scope of that ambition gas collapsed entirely, leaving just the hope of an exploratory MV trial.

As far as the failure to hold an AGM goes - this is just poor and cannot be excused by saying they're just well intentioned science bods and all theis business stuff is not really their thing. It's a business - run like a business properly until this summer and whatever the state of the company's future ambitions, they are legally obligated to discuss the previous year's activity and current state of the business. If they shrink back into academia - as seems likely - they will no have to meet these tiresome obligations.

Finally if you're worried about toxicity with respect to Fruits, Gunto and Tommyd - you might remember that they have been serially abusive of other posters for a very long time. Anyone who offered an alternative to their ludicrous happy clappy narrative, branded trolls or more usually multi-account trolls. Relentless - day after day abuse. They give it and they get it.

We said Sprinter was a badly designed trial - they said TROLL. We wanted to discuss missed deadlines and constant delays. They replied TROLL. We said money might be running out - they said TROLL. We said the market place for the drug was shrinking because of competition - they said TROLL again. Of course despite their denials - all of these concerns have since proven to be justified.

So many other examples as the share slumped down to its current level - where these 3 posters told us all was well, and encouraged LTHs and newbies to invest more money in what was clearly a failing project.

We’re not the problem - we’ve been right every time, and we'll continue to hold the company to account, with or without an AGM

It's only Td and Fruits who believe the AGM to be an unnecessary distraction. I'm becoming increasingly concerned for Fruits though. Not Td - he's a villainous company stooge. But Fruits was once one of us. As erudite, balanced and good humoured as anyone. The Fruitloop monicker was a bit harsh when it was first coined, but he really is getting madder by the day. Like Hitler in the crumbling Berlin bunker, moving long decimated armies to imaginary front lines. Fine if you still believe in the science to retain some optimism that someone might help us do the MV trial, most of us hope this, but to deny any of the outrageous calumnies of the last 2 years and still be writing " I've lost nothing - I haven't sold ! " is just plain bonkers. You have lost Fruits. Plenty. And you'll get a tiny fraction of it back, regardless of what happens from here. Your non-dilutory rescue plan is a figment of your imagination. Along with the ghost armies of world class scientists and big pharma partners you imagine Dickie Marsden still commands.

someone with more knowledge than i will have to explain it gampy. (there are quite a few..) here's another mouse study from 2018 exploring the role of ifns in ards sepsis.

"recently, an open-label trial of systemic ifn-β improved 28-day survival in patients with ards (29). ifn-β is a type i ifn family member usually produced in response to viral infections and various pathogen-associated molecules (e.g., lps), and it exerts pleiotropic effects such as viral inhibition, tumor killing, and immune modulation (30, 31). ifn-β also stimulates expression of ecto-5′-nucleotidase (cd73) in cultured endothelial cells (32) and in human lung tissue explants (29), which is associated with increased adenosine production, improved endothelial barrier function, and reduced vascular leakage, suggesting that ifn-β may function to reduce pulmonary edema. in murine models of sepsis and endotoxin-induced shock, ifn-β improves survival, possibly by silent mating type information regulation 2 ****log 1–mediated suppression of exaggerated cytokine expression (33). thus, ifn-β holds promise as a disease-specific therapy for ards, but there is insufficient knowledge about its potential therapeutic benefits.

patients with severe peritoneal infection usually experience nosocomial infections with high mortality. lung innate immunity, including the bactericidal capacity of alveolar macrophages, is impaired and may be associated with susceptibility to nosocomial infections. potent immune-enhancing mediator ifn-β restores functional impairment of alveolar macrophages and may be a new therapeutic target for sepsis-related immune suppression.

https://www.ncbi.nlm.nih.gov/pmc/articles/pmc6835072/

I think this is the relevant sentence Gampy from Td's AZ study “ IFN-β was 100-times more potent than IFN-α at inhibiting type 2 cytokine production by lung ILC2s”

Admittedly from a mouse study and not since proven in humans afaik - but it chimes with that very old and oft quoted phrase about SNG " wanting a fire to put out" which surprised the Synairgen scientists in the analysis of SG016.

Fruits " No doubt some catalyst was triggered by the data they were seeing in Universal. That, or they are running secret lab experiments that have provided new insights. Which do you reckon it is? "

Assume the second part of this is an attempt at humour. ? The first part - and your linkage to the new hires - is impossible as there was no data to look at this time last year.

They've subsequently seen data from between 300 and 500 UNIVERSAL patients, added it to their own data, looked at the reality of the new drugs for COPD and soon Asthma, and binned the main project. The RNS was really clear.

1. Completed a full assessment of the underpinning science, clinical trial data, clinical need and commercial opportunity to determine next steps for SNG001

2. Commenced preparatory work in 2023 to deliver a trial focusing on mechanically ventilated patients who we believe are the most attractive near-term patient group with respect to the extent of the unmet need, the commercial potential in a clearly identifiable population and the clinical development route for SNG001

3. Recognised that opportunities for potential future assessment of SNG001 in platform trials and/or academic trials may materialise in the event of an emerging virus threat"

You may take comfort in the phrase "near-term" in the second bulletpoint but point 3 makes it clear that the company doesn't share that optimism, and believes that unless there's a ground zero event - the future will be the success or failure of a mechanical ventilation trial.

UNIVERSAL is point 4. Not their trial & Not going to change the future.

Apart from Fruits and Gunto's silly sniping there is actually a decent discussion taking place on here today. Spacman and pmjh talking to each other with others chipping in. Pmjh ever the optimist - in a good way - Spacman leftfield but always knowledgeable. And TP setting the parameters - daring to mention the unmentionable about UNIVERSAL and asking sensible questions.

Your computer's in a worse state than Mani's Gunto. Sell up and get yourself a chromebook ( £80 at Argos)

Your contributions are equal parts childish malevolence and knuckle drag ignorance.

If you want to contribute like an adult let's have something. You can choose the topic. Anything related to Synairgen that's your own work and not nicked from the grown-ups on Redditt

Maybe something on UNIVERSAL - as that's the topic in discussion. What's your take...........eh ?....... no i thought not.