Member Info for daveycaferacer

thx Azurite. Was there any mention of the Savolitinib update in their comments today?

https://business.nasdaq.com/mediacenter/pressreleases/1862594/annual-changes-to-the-nasdaq-biotechnology-index

thx- I was aware of the MSCI Index addition but not the NASDAQ Index one....

My stance has changed from Buy to Hold for now, after my purchase this morning. I'd like to see some more positives on the pipeline before continuing with my accumulation strategy.

miti - There will be very big volume tomorrow in the US on HCM ??

There are a number of positives, unfortunately the negative updates dominate

I think both updates have many positives & negatives, the biggest negative is the one miti has touched on - MES:-

1. recently completed the largest MES study conducted on PRCC patients, which was aimed at developing a more comprehensive understanding of the role of MET-driven disease in PRCC.
2. Sutent® (sunitinib) (VEGFR TKI) in first-line PRCC was effective, providing similar tumor control across MET positive and negative patients
3. Incidence of MET positive PRCC patients was lower than previous scientific publications and the savolitinib US Phase II study;
4. ? Incidence of MET positive PRCC patients was lower than previous scientific publications and the savolitinib US Phase II study;

As a result, the savolitinib registration strategy for PRCC is being reassessed, Enrollment in the SAVOIR study has been suspended.

It appears that in PRCC Savolitinib offers no advantage over Sutent which is contrary to what was previously expected

Agree Goldstinger, will be hitting the Buy button within the hour!

The market doesn't appear to like the updates today, especially regarding SAVOIR, which was not expected

Hoping to get some positive on Savolitinib within the next week

Director Buys show confidence to the market, upwards from here IMO

Analysts have trimmed their estimates, but also have share price targets way above the current £26.14 price. I expect a decent rise in the price today.

I would otherwise you will miss the dead cat bounce I suspect

I may invest some of my ASAO profits from today's plunge trade, or may wait a bit longer, this is now in bargain territory, although a gamble

fair enough Wuffle but my point is the influx of cheap labour from eastern Europe has prevented wages from rising

Yet another Business blaming Brexit when the reality is the influx of cheap labour from Eastern Europe has kept wages low whilst inflation has returned, meaning people's disposable income has been squeezed. In the long run a proper Brexit will help businesses like Asos.

Well overdone, should get back to over £30 in the next day or two IMO

Almost 1 million ADR's traded today on NASDAQ

the reality is people at this cheap end of the market go to Primark

"We believe that uncertainty surrounding Brexit........."

How silly

This brand is favored by 40 year olds pretending to be younger than they are. It was a fad and a trend which has had its day. High lease costs allows little flexibility in a dowturn. short..