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I'm not going to discuss the charts or James Barder or market makers. I am simply going to discuss the science. I hope after reading the below some of you are reminded of the science that should (hopefully) get some value for us long suffering share holders.

What is GTN?
Glyceryl trinitrate works by being converted in the body to a chemical called nitric oxide. This chemical is made naturally by the body and has the effect of making the veins and arteries relax and widen (dilate). When the blood vessels dilate in this way there is more space inside them and hence less resistance.

ED Patients
ED patients have a narrowing of penis blood vessels. If Diabetic, they can’t produce the natural levels of Nitric Oxide thereby impacting dilation of blood vessels even further. Severe ED patients may possibly have a greater degree of narrowing of blood vessels and therefore require greater levels of nitric oxide to have the desired effect.

Increasing the concentration of GTN should increase the levels of Nitric Oxide and has been proved by various studies, i.e. concentration-dependent increase in nitric oxide.

Speed of use
When using the 0.2% GTN gel there was a 5 mins to 10 mins speed of onset, however it was not possible to break out from placebo for this. The 10 minutes also corresponds to the peak level of MED2002 in blood plasma as seen in the PK Study. The reading after 10 minutes for the 0.2% dose was approx. 1300 g/ml
The peak levels for 0.4% GTN was about 2650g/ml also achieved in approx. 10 minutes. The level of 1300g/ml that was achieved by the 0.2% in 10 minutes was achieved earlier than 10 minutes for the 0.4% GTN and therefore whatever the 0.2% achieved in 10 minutes, the 0.4% should be able to do quicker.

The peak levels for 0.6% GTN was about 3700g/ml also achieved in approx. 10 minutes. The level of 1300g/ml if achieved by 8 minutes for the 0.4% GTN would be achieved quicker for the 0.6% GTN, for example 6 or 7 minutes. (times used to explain the difference)

Based on the above, the higher doses should be able to break out from Placebo as the concentrations achieved by the 0.2% in 5 to 10 minutes would be achieved by the higher concentration GTN doses at an earlier time frame..

Hopefully I've managed to explain some of the science..and good luck all

Just agree to disagree and move on

I hear you Kencarv, frustrating it certainly is, however eventually it’ll come good. I’m the meantime make use of the low prices by buying more (should funds / portfolio allow) GLA

Not sure why the panic? The repetitive posting of the same facts will not drive the share price higher. Give it time. Eventually it’ll come good.

The lifting of the NDA should in theory help, as it allows STARCOM to include the company name when bidding for other work..

Blue chip companies always like to see other blue-chip companies in the list of clients when awarding work...

Good podcast that gives a real feel for where the company is heading Good luck all

Link?

There was a test flight done with Nexeed Track and Trace earlier this year - Bosch and Panalpina

"On the first test route between Germany and the recipient plant in the U.S, each package was equipped with a sensor. It records regularly relevant parameters such as vibrations. At each gateway, for instance when unloading the truck at the terminal or loading the airplane on the runway, data and the location of the time-sensitive goods are transmitted to the cloud. The Panalpina sees whether the goods have been loaded into the airplane and how they are doing."

Given it was a test flight there would be some improvements and adjustments to be made to the product... Evident by the following update today

"We have delivered the first order for the major European industrial group with whom we have a collaboration agreement, as well as the modifications and adjustments they subsequently requested. We expect as a result of this to see further orders during the second half of 2018. We have obtained their agreement to disclose their details within the upcoming financial report."

And most recently in June the following news was released by Panalpina

"Panalpina has launched a digital Hub to “embrace new technologies” that have the potential to disrupt its freight forwarding business.
The Panalpina Digital Hub, which reports directly to chief executive Stefan Karlen, will have a focus which includes the Internet of Things (IoT), cloud computing, predictive analytics, artificial intelligence (AI) and blockchain.
The Switzerland-based logistics giant said that the hub will explore “innovative technologies, develop new digital solutions for customers, and engage with digital start-up companies”.
Said Karlen: “We, like many of our competitors, are challenged by new market entrants, with innovative business models and digital approaches that improve upon the old way of doing things.
“Additionally, our customers increasingly demand the digital experience they have become accustomed to as consumers: they now expect a similar experience in a business-to-business environment.”
Karlen added: “It is therefore obvious that the frontier of freight forwarding and logistics does not lie in new modes of transport, but in digital transformation.
“Knowing that, we want to shape our industry’s future with innovative digital solutions that create new levels of value for our customers and accelerate growth for our company in the years to come.”
IoT is a technological development whereby all sorts of devices like smartphones and computers are connected to the internet.
Luca Graf, head of the Panalpina Digital Hub, said: “In the short term, IoT can help us streamline our processes and create more efficient supply chains. The challenge will lie in deriving the relevant actions from the wealth of IoT data.
....
you can google the rest
https://www.aircargonews.net/news/freight-forwarder/single-view/news/panalpina-embraces-disruptors-with-digital-hub

https://insideevs.com/nio-teams-with-bosch-for-ev-related-components/

I meant latest Linked-In message

I wonder if the latest tweet by starcom is connected to this in any way? subtle clues or we're reading too much into it?

Bosch and EV company NIO signed a strategic partnership agreement focused on sensor technology, automated driving, electric motor controls, and intelligent transport systems

I think by far the biggest plus point for me was that this company had already done some due diligence prior to entering this agreement with ReNeuron. As the presentation pointed out, ReNeuron effectively opened up their dataroom to the companies they were in discussions with and clearly this company had seen something to have interested them to the extent they are willing to pay 5.0 million dollars (in 2 stages) for the privilege.

Excellent initiative by the company, the first time I have seen a commercial intent shown by the company, hence back in.
GLA

Welcome back. I find it ridiculous that the company is on the verge of signing potentially a fortune changing commercial agreement and yet is valued at these low levels. This could really spike if the agreement takes place . I note this could be the first of a number of new agreements

Good news indeed Patent life question was asked at the 2017 AGM and the response was that it is currently 2028 but likely to be extended to 2036!

Gents Over a billion dollars in sales does not equate to billions to Futura Medical Futura Medical will get Royalties However even if you assume 10 percent royalties and a lower figure of 500 million dollars, that equates to 50 million dollars per annum Operating costs of 6 million dollars leaving 44 million dollars profit per annum before tax This equates to 30 million pounds EPS = 25p per share Biotech’s go for higher PE ratios but Using a PE of 15 we arrive at a share price of £3.75 Obviously increasing royalty and PE ratios changes this. For example a royalty of 15 percent and PE ratio of 20 changes this to £8.30 ish whilst still using the lower forecast of 500 million dollars. I prefer to use the lower forecast of 500 million dollars even though the research indicates peak sales in excess of a billion dollars.

Why is the 1st of September being mentioned? Dosing of first patient is meant to be by end of September

Tradedesk, I might have misunderstood.. you wrote “Yes, a pre close update on H1 in July not been done before so bodes well that they are commiting to one” I note your response to my question, but Your response does not imply we are due a pre close update on H1 in July, neither does it mean they are committing to one. I’d hope for update by the end of July or early August.

if they have not committed to providing an update in July, then please refrain from misleading people Still awaiting feedback ....

Where have they committed to providing an update in July?

I topped up @31.4