RE: Excellent article...albeit lengthly31 Jul 2017 13:02
Thank you Freddie. It's a bit like learning a foreign language - reading through, one's brain switches off after a while. However, that said though, this article does make one realise just why the rewards will be incredibly high for Reneuron and its shareholdrs when it reaches a commercial conclusion from the PISCES trials (Ischemic stroke).
We know that patients on the PISCES II trial, despite long after their initial stroke when medical experience says they'll be NO further improvement, actually registered meaningful improvement. But, for Reneuron to prove that it is because of their CTX treatment is the conundrum which remains to be solved.
For anyone new to Reneuron, here is a paragraph I extracted from the report>
QUOTE
Human neural stem cells in patients with chronic ischaemic stroke (PISCES): a phase 1, first-in-man study.[Lancet. 2016
Due to the small number of patients treated in the trial, their heterogeneity as a study population, and the open-label, single-arm study design, it is not possible to draw reliable conclusions about the effects of CTX cell implantation on neurological or functional recovery. However, it was possible to note that despite the selection of chronic, stable patients at late stages after stroke, most showed some improvement across several indices of function [9]. Whether attributable to cell implantation or to other factors, such as extra medical attention, a change in this patient group suggests that trials of interventions are worthwhile late after stroke, when recovery is not generally believed to be attainable. The researchers also described anecdotal accounts of reduced spasticity, minor return of finger movement at phalangeal joints, and improved visual perception and better bed-to-chair transfers, which were supported by the changes in health-related quality of life, activities of daily living, and neurological impairment. ENDQUOTE