Member Info for D-Geeman

Hi Wyn, I just noticed your post elsewhere, checked the RSI here and brought over a little more (freed up by selling some RUA this morning). I already have more Capx than Xeros so made sense to equal them up a bit.

It's so tricky isn't it. You'd have bought more here on the drop but I nearly sold on the RNS as it seemed a bit too 'jam tomorrow' again even though there wwere some very promising hints (which I actually thought you might dismiss).

But the SP held up RNS day pretty well and the trend for the last year is still up. I guess there are resistances just below 2p and then again just above 2p but then could arguably headed nearer 3p if things went well?

'Today 09:44

Don't waste time responding if your handle is ........ D-Geeman '

You sound like a teenager with a statement like that B2HS2L.

In this context that isn't a compliment.

Wasn’t wyn comparing this BB to ‘Lord of the Flies’ classic story?

Well for those who don’t know the story I just caught a trailer for new BBC production starting soon;

https://www.bbc.com/mediacentre/2026/lord-of-the-flies-trailer

'and bucket to collect their donations for his roses.’

'collect the dung & yes then spread the manure around the Roses'

I understand that Watching does this too but with her Quality Street, not Roses.

Evan Davis discussing mergers and acquisitions on Radio 4 right now.

Many of the most useful posts are green boxes to others. That's fine.

I really don't care if **** doesn't read ****'s post as long as I can. Please, everyone who doesn't like ****'s posts filter and then the people who do read them can do so in peace.

An elderly character actor in our road, when I first arrived, was in the movie ‘The Dambusters’, and in ‘Bridge on the River Kwai’. He used to tell some good stories of life on 1950’s film sets. Dead for a while but he pops up on screen even now.

I thought about selling (relatively small investor here so not worth selling half) but didn't and glad I didn't.

Sounds like you have held on too Wyn.

'And people like you, L L, who constantly post ramping messages, claiming the company always reports the whole picture, who cannot bring themselves to see that maybe, just maybe, after all these years, all might not be sweetness and light.'

Nope, too many commas for Wyn. Wyn's max is 5 and this has 7. Wouldn't stand up in a TV who-dunit.

I can’t find it (you’re quite prolific!) but didn’t you post that Kemi Badenoch was saying good things in your opinion. She is on desert island discs this morning and made a lot of sense. BBC Sounds if you’re interested

'won on bet Fred '

Was it an accumulator?

No need to thank me.

AI probably quite good for this sort of thing:

‘ The starting dose in a Phase 1 drug trial is a critically calculated low level, derived from preclinical (animal) toxicity data (like the No Observed Adverse Effect Level - NOAEL), scaled to humans, and then reduced by a significant safety factor (often 10x) to ensure patient safety, aiming to avoid toxicity while being high enough for potential biological activity, balancing risk and efficiency. Regulatory guidance (FDA, EMA) provides frameworks, but the exact dose is unique, using methods like the "Maximum Recommended Starting Dose" (MRSD) calculation, often involving human equivalent dose (HED) conversion and safety margins.

Key Factors in Determining the Starting Dose:

Preclinical Data: The NOAEL from the most sensitive animal species is a primary input.

Species Scaling: The NOAEL is converted to a Human Equivalent Dose (HED) using specific scaling factors, often based on body surface area.

Safety Factor: A safety margin (e.g., 10x) is applied to the HED to get the MRSD, ensuring the initial dose is far below predicted toxicity.

Drug Type: Different rules apply to small molecules (often escalating by ~100% or half-log) versus biologics (often half-log or 3x increments).

Trial Goals: While safety is paramount, the dose shouldn't be so low as to be sub-therapeutic, minimizing unnecessary exposure to ineffective doses. ’

‘ posters are filtered …. getting hardly any ticks on their comments’

You can see the number of ticks on filtered posts?

That’s new to me.

Cheers Thorn. I will still mention to him and his wife. They can ask the surgeon later on. Maybe surgery alone will work. If nothing else it will show to the team that they are looking into trials.

Will the trials all be in the US?

(Relative is having 'whipple procedure' carried out shortly. I'd like to keep them informed.)

I have the priviledge of having bought just ahead of the rise :-) Mine was '13.95 14,645 '.

Was feeling nervous at being more or less out the last few months and with news on the way. Hopefully I can free-up more elsewhere before long.

Morning again Wyn,

'emotionally no problem with doing a 180 even within 24 hours. (yes, i am a bit peeved that this was not released at the same as yesterday's RNS, but hey ho its the cost of doing business'

You do better than me wyn. I had spent yesterday's money but actually I decided to take the small but improtant profit here and have put into *RUA* (instead of AVCT as I dont want to pay more than I sold for; I know, it's a problem..) which is due news. Then I will bring it back here with perhaps a little going to AVCT when time passed will mean it no longer matters.

G4M seems to be a very safe haven now.

Rivaldo, sorry to disappoint but one buy was mine and only bought as I freed up money elsewhere that I just brought back to RUA.

'had a phone call with Mr Brown.'

That is a first on these BB's. Will await your post with great interest. Please do comment on the 'mood' too..

Bella, my computer is very slow today so I won't scroll back but I think you wrote 'imo.. they have a partner'.

We are led to believe by CC herself that they are talking to multiple potential partners (wouldn't mean much on a dating site) but if they HAVE a partner then CC would presumably be breaking disclosure rules by keeping it quiet. That's what I meant.