RE: REMAP22 Jun 2020 11:58
Sax yes this does appear to be the ongoing consensus that the both will work
"Immunomodulation is complex, and timing of the treatments is critical. There are a limited number of direct studies on the timing of immunomodulatory treatments such as IFN-beta, but given our basic understanding of human biology and viral defence, we suggest that IFN-beta should be given early to COVID-19 patients. In mild cases such as in the recent clinical trial, even s.c. administered IFN-beta was effective [1], but in more severe cases, i.v. injections are needed to rapidly reach the endothelium. As ARDS rises together with a cytokine storm, corticosteroids may play a beneficial role during the later fibrotic phase or just by calming down the cytokine storm after IFNs have had their impact. This is supported by Villar et al. who showed that the use of dexamethasone was associated with better survival in ARDS [12]. A notable feature of this study is that the enrolled patients were not on steroids when entering the trial"