Member Info for CTSFO

So… the traders are out of here today buying Jay. They’ll sell tomorrow and come back, knowing there’s more good news on the way. Buy the rumour, sell the news.

Touk, if you’re stating these are FACTS, can you please provide supporting evidence? Or is this your opinion?

Fact: AVA6000 half life is to low and it is being excreted too quickly

“Fact: a strong enough level of AVA6000 isn’t in the TME long enough to allow cleaving of efficacious level of dox to the tumour

Fact: p1 has been altered to more frequent dosing in order to try to counteract this issue

Fact; a new drug has been developed that doubles AVA6000 half life to try to counteract this issue

Fact: There will be a limit to the amount and frequency of AVA6000 that can be delivered if kidney damage is to be avoided.“

Especially the threat of renal dysfunction. No way on God’s Green Earth would Q3W move to Q2W if there was a risk of known, worsening, nephrotoxicity.

“ You need a crystal ball CTSFO.”

We all do!!

GLA

Thorn, thanks, just looked at the slide.

Looking at plain doxorubicin, there are mixed results comparing bolus dosing with continuous infusions. Sarcoma and ALL in children did worse with continuous infusions. So it isn’t as straightforward as it seems re dose and effect.

AVA6000 is both a new drug and proof of concept of a novel delivery system. Choosing doxorubicin is inspired because so much is already known about this warhead.

The t1/2 of AVA6000 is an interesting point. The fact that it is so safe means its peak equivalence concentration of free doxorubicin can be much much higher than plain doxorubicin at present. Q2W dosing again is showing a significantly improved safety profile. Does the move from Q3W to Q2W mean Q3W didn’t work? I don’t know. I’m more inclined to believe Q2W is the sweet spot of delivery interval, effect, and side effect. This mix making it much better than Q3W. And ICE has an important (very important) point. AVA6000 can be given more than 6 times. Tumour suppression vs outright complete destruction. People die with a cancer, not of a cancer.

The other platforms and t1/2 modulation I take to be of use with newer, much more toxic, warheads. Agree these will take much more money and time. But. Once Q2W is completed, assuming excellent results, BP will take Avacta more seriously and the IP they hold. I can’t see Avacta going it alone with its newer agents.

I’m not a moron.

Thorn, where has half life extension been mentioned?

“ So with a short half life you have to give it again and again and again at frequent intervals, hence they're working on plasma half life extension platforms that will make it a bigger molecule and might affect it's ability to penetrate the tumour effectively.”

I can’t find mention of that.

People simply haven’t understood the potential. They see a polymer producing company that’s making a loss, even though the figures are improving. The DYOR behind medical devices is different to that for biotech pharmaceuticals. They move on, if they bothered to stop at all.

That needs to change. The next good news RNS needs to get spread far and wide. MSM and medical media need to get behind a home grown success.

It’s potentially useful to both. If the world turns against fluoropolymers, they will need a replacement. These facts already sell the HVR:

“flex fatigue testing for durability passed 400 million cycles equivalent to 10 years in man.

· a heart valve made of the composite has achieved the key 200 million cycles required by ISO standards for a flexible leaflet heart valve.

· hydrodynamic testing demonstrated valve efficiency around 50% better than current technology.

· valve flow area is around 25% larger than similar sized valves in the market.

· Recent patent filing to protect the new IP entitled "Composite Material, Heart Valve and Method of Manufacture".“

The fact it’s fluorine free is icing on the cake!

GLA

TESLA HAS SOLD MAXWELL TECHNOLOGIES:

Tesla bought Maxwell in 2019, then sold it in 2021. But it kept the IP on dry electrode technology. It appears they just wanted that to improve their planned in house development of batteries.

https://electrek.co/2021/07/21/tesla-tsla-sells-back-maxwell-technology-ultracapacitor-business-to-former-executives/

Read this on the CPX bb.

“The best supercapacitor binder material has traditionally been PTFE due to its insulating properties and hydrophobicity towards the electrolyte. Due to these features, the active material has a higher internal resistance and is less effective [43]. There is a growing demand for eco-friendly, fluorine-free alternatives to commonly-used fluorinated thermoplastic binders like PTFE [44].”

Potentially important for us. Goretex grafts are the present standard within healthcare. Made out of PTFE. There’s a significant pressure within NHS to consider the environmental impact of healthcare. The anaesthetic agent desflurane has stopped being used because of its greenhouse effect.

Not sure what the other polymer added to Elast Eon is in the HV material. But if it’s fluorine free, this is an important point going forward.

GLA.

Parkez, I’m copying your post re flourinated plastics and using it on the RUA bb. That’s very interesting indeed. Sorry for the cross posting!

Parkez, quick apology. My post about “serious answer” starts with what reads as a patronising response. It wasn’t meant to. I wish posts could be edited. GLA.

Supercapacitors and maximising grid stability:

https://www.skeletontech.com/skeleton-blog/maximizing-grid-stability-how-supercapacitors-are-shaping-the-future-of-e-statcom

“ What do we have that they would want?”

Serious answer: the soon to be announced IP / patents and all the to-date research held within the company?

There has to be very good reason(s) for Dr C and the other new NEDs to want to join CPX. If I’ve read it right, his background is ‘big stuff’. Power systems engineering. Not so much handheld tech (sorry if I’m wrong). He has to have seen the something that he knows will be of use in decarbonisation of electricity generation, supply, and usage. With the roll out of SMRs (small modular reactors) and increasing use of intermittent renewable energy, something has to bridge the variability between generation and demand. Hybrid supercapictor batteries have to be part of the solution. IMHO.

2018. Literally old news.

What’s a V shaped bull flag please?

Every fecking time it hits .25 back down it comes. FFS.

I agree. The sp will keep doing this till 2,000,000,000 0.1p placing shares are churned through the system.

As dense as U238?

I totally agree it’s not a pump and dump. I did say that a few posts back. We may see delayed trades posted later which are significant sells, this would explain the rapid sp drop. We know there are a huge number of 0.1p shares out there. People are taking a healthy profit selling these. I’m no fan of MMs, and they certainly play games, I’m just thinking the sp activity today isn’t just the MMs.