Roundtable Discussion; The Future of Mineral Sands. Watch the video here.
https://www.nytimes.com/2023/02/03/opinion/bird-flu-h5n1-pandemic.html
thanks JHF
Science direct:
''For any pharmaceutical company or academic institution, it is a big achievement to advance a drug candidate to phase I clinical trial after drug candidates are rigorously optimized at preclinical stage. However, nine out of ten drug candidates after they have entered clinical studies would fail during phase I, II, III clinical trials and drug approval''
I think the more learned on here have mentioned in the past about perhaps de-risking through Phase 1 - maybe withdraw original outlay or a fair bit of it...I guess it depends on one ones appetite for the ride...
Having said that, the reasons for failure, I dont think will manifest in HEMO CAR T (or not to the probability indicated below). I would like to think HEMO have exhausted the process to date - poor clinical efficacy seems less likely than 40/50% - but WDIK - time will tell.
Beyond the value potential here wouldn't it be incredible that potentially people dont have to go through chemotherapy, bone marrow transplant and all the associated horrors of conventional treatment if this comes off.
''Analyses of clinical trial data from 2010 to 2017 show four possible reasons attributed to the 90% clinical failures of drug development: lack of clinical efficacy (40%–50%), unmanageable toxicity (30%), poor drug-like properties (10%–15%), and lack of commercial needs and poor strategic planning (10%)2,4. Generally, drug development follows a classical process''
GLA
https://twitter.com/vmsandler/status/1621338968322088961?s=21&t=PtMjOIOAIzj4I96W4L2ZKA
thanks mr. I
interesting
''I’d finish with a word of caution: HEMO is pre-clinical, operates in an exceptionally complicated scientific space, and is nowhere close to a regulatorily approved treatment for any of its breakthroughs. Avacta, for example, is far further along this road with its treatments, but then this is reflected in its market cap.''
interesting.
I guess by 'nowhere close' he means successfully through Ph1 and beyond...
I cannot believe even the most sceptical and HEMO weary, in quiet moments of reflection, dont think,
'mmmm this could really motor on a bit of good news...'
£23m - its absolute freakin peanuts...
GL LTHs and some STHs