Member Info for ChrisToffer

Completely get your frustration Doc. The potential of this drug to help over 60s and those at risk is huge! I guess all the company can do is keep doing it the right way and hopefully the authorities/government wake up sooner rather than later and promote/deliver SNG001 for those who need it most.

Doc I interpreted your comment as the trial would not start for months (Apologies if that was wrong). Yes I agree it'll be Q1 before recruitment is finished. However given the speed with which the P2 (2 weeks) started I would expect it to be up and running in November. Agree that there's nothing to suggest we'll get EUA but the statement from WHO last week on Recovery makes me think there will be unmet need when things get out of hand again during winter. I think we'll see EUA this side of xmas.

"definitely months away for P3. There must be a chance it won't even start until next year." Anything to substantiate this? Everything is pointing towards a November start to the trial and the IND links below would suggest the trial doesn't necessarily preclude EUA.

Thanks Joey, 'The emergency use of an unapproved investigational drug or biologic requires an IND'. That reads like the IND is not just a pre-requisite to the trial commencing, but also an EUA?

'Once the IND is submitted, the sponsor must wait 30 calendar days before initiating any clinical trials.'

Does anyone know if this will only apply to the US arm of the trial? Is there a possibility that the trial will begin elsewhere in the meantime?

Hi Matt, when I said cost of accepting financial support from government; that cost may have meant joining a larger government backed trial (with less control). It may have meant a commitment from SNG on supplying the UK first, or at a low price. So government involvement may have resulted in giving away too much control over this drug that SNG have spent 15 years on.

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Careful what you wish for guys. The reason SNG001 was not included in any large trials (Solidarity et al) was because SNG felt they could deliver the trial quicker without such inclusion. It also meant they were able to maintain full quality control over the trial which resulted in a high quality dataset. Look what happened to Faron last week who are now trying repair an image that was damaged by factors out of their control.

Similarly with government; Though I find it appalling that government have done nothing to promote the home trial, there would always be a cost to accepting financial support.

"The ability to rapidly scale the production of SNG001 will allow Synairgen to meet expected clinical and commercial demand for the drug"

The certainty in that statement! It's only a matter of time!

It was RNS'd, last week. The comments from RM are new and the fact he hasn't done an SNG (proactive) interview suggests to me that there's a piece of this puzzle still missing.

Eva, the Company can and are likely to be generating revenue already through the MAP agreement.

Org, the vaccine sentiment that you allude to will be PI sentiment. Last weeks fundraise had an II to PI allocation of 80 to 7. IIs know that there's a need for both and they supported that with £80m in a matter of hours. Vaccine is clearly not a concern for them.

Yea a few on here have mentioned their brokers won't do the same so I'm not counting my chickens till its done!

Thanks Jint, reassuring to hear you got told the same thing! Hopefully have the corporate action tomorrow. Be a shame the lose the allocation as I was fully loaded on the ISA before 20th July.

Halifax told me on the phone that I can purchase my full allocation (inc. ISA where I've used my full allowance) on my normal account. They said to call them, though I haven't got the corporate action yet so still to test this.

I understand theres a 4 weeks break after IND application before trial start but does that only apply in the US?

Quickbuck, thats sounds like you may be over complicating the matter. Im in exactly the same situation with an ISA where i've used my full entitlement.

I called the Halifax the other day and they said I can call them and purchase my full entitlement (ISA included) in my normal shares account.

Morning everyone,

Is there a link available to Professor Holgates interview the other day? Couldn't make it myself.

This shows that SNG's decision to go it alone without government support or inclusion in these large trials was fully merited. Faron didn't have full control over this and now they're paying the price.

"...higher peak concentration in the lung vasculature without higher systemic exposure, which we believe makes this method of administration highly effective and safe." If they're saying the method of delivery is that important, what does that mean for Inhaled delivery.

"Somewhere in all the medical blurb will be a reason for no big fish participants."

The medical blurb is solid. Maybe they weren't willing to pay the price? Regardless, the show goes on without them.

Ah get ya now! I'm not sure we'll see any TR-1 until the shares are admitted on the 19th?